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Extramural Programs and Contacts (Listed by Contact Name)

Listed by Program Contact

[List by Division]
[List by Program Class Code]

These pages provide the telephone numbers and e-mail addresses of key NIMH Program Staff, each of whom are responsible for an area of extramural science. These are the staff to contact regarding questions on submitting grant applications and funding opportunities at NIMH.

Also shown are the Extramural Program Titles, a short description, and Program Class Codes (PCC). PCCs are used to identify the extramural programs in NIH computer system records and on various printouts, such as summary statements.

NIMH's mailing address is:
National Institute of Mental Health
6001 Executive Boulevard
Room#
Bethesda, MD 20892- MSC#
(Specific Room and Mail Stop Code (MSC) numbers are listed after 'Neuroscience Center' in the Contact info)

Alphabetical Listing of All Staff
NIH Telephone & Services Directory 

Anjene Addington

301-443-6653
Genomics Research Branch
Neuroscience Center/Room 7190/MSC 9643

1J-GRTS1 / Genomics Team Science Program

Division: Office of the NIMH Director

Description: This research program contributes to the development of strategies and supports collaborations to advance the field of psychiatric genomics. In addition, this research program focuses on the dissemination and promotion of NIMH-sponsored research on genomics and personalized medicine.

74-GR / Genomics Research Branch

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Genomics Research Branch plans, supports, and administers programs of research including the identification, localization, and functional analysis of genes and other genomic elements that confer susceptibility to mental disorders and their related phenotypes and underlying biological processes. Areas supported by this program include, but are not limited to: • Studies using genetic and molecular epidemiologic methods to identify genetic, genomic and environmental risk factors underlying the etiology of mental disorders and their related phenotypes and underlying biological processes. • Identification, localization and function of genes and other genomic elements that confer susceptibility to mental disorders and related dimensional phenotypes • Translational genetic studies including epigenomics, non-coding functional elements, and integration of multidimensional data to computationally and functionally validate potential underlying networks that lead to disease. • Development of novel statistical and bioinformatics tools that aim to overcome the unique challenges of elucidating the biological basis of brain disorders. • Collection and genomic characterization of diverse ancestral populations to expand the NIMH Genetics Initiative

74-GRE / Genetic and Molecular Epidemiology of Mental Disorders Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: This program supports research using genetic and molecular epidemiologic methods to identify genetic, genomic and environmental risk factors underlying the etiology of mental disorders and their related phenotypes and underlying biological processes. Areas of emphasis include population based studies, using national registries or healthy systems, family studies, longitudinal cohort studies.

74-GRM / Genetic Basis of Mental Disorders Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: This program supports research on the identification, localization and function of genes and other genomic elements that confer susceptibility to mental disorders and related dimensional phenotypes (including autism spectrum disorder, attention-deficit hyperactivity disorder, bipolar disorder, depressive disorders, eating disorders, obsessive-compulsive disorder or other anxiety disorders, panic disorder, schizophrenia or other psychotic disorders, personality disorders, post-traumatic stress syndrome, and Tourette syndrome). Areas of emphasis include discovery using whole genome approaches in large case control cohorts or well characterized multiplex family collections or trio designs for detection of de novo events.

74-GRR / Genetics and Genomic Research Resources Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: Collection and genomic characterization of diverse ancestral populations to expand the NIMH Genetics Initiative. This program also supports the development and distribution of novel computational, statistical and other bioinformatics tools for the analysis of genetic and genomic data in psychiatric genetics.


Ishmael Amarreh

301-451-5132
Office for Research on Disparities and Global MH
Neuroscience Center/Room 7211C/MSC 9659

15-SGG1 / Global Mental Health Research Program

Division: Office of the NIMH Director

Description: The program supports research focused on generating the major scientific advances needed to make a significant impact on the lives of people living with neuropsychiatric disorders worldwide. Topics of interest include task-shifting, cross-national influences on neuropsychiatric disorders, cross-national comparisons of treatment delivery models for neuropsychiatric disorders, and factors influencing broad uptake of interventions in a variety of global settings.

15-SGT / Research Training & Career Development Program

Division: Office of the NIMH Director

Description: The Research Training and Career Development Program supports research training at the high school, pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Office for Research on Disparities and Global Mental Health. This program suports research training, research education, the NIMH Diversity and Re-entry Supplements Programs, capacity-building and research infrastructure development.


Susan Azrin

301-443-3267
Services Research and Clinical Epidemiology Branch
Neuroscience Center/Room 7145/MSC 9631

82-SEDRA / Dissemination & Implementation Rsch Prg

Division: Division of Services and Intervention Research (DSIR)

Description: This program includes studies in general medical settings that will contribute to the development of a sound knowledge base on the effective transmission of mental health information to multiple stakeholders and of the process by which efficacious interventions can be adopted within clinical settings. Research on dissemination will address how information about mental health care interventions is created, packaged, transmitted, and interpreted among a variety of important stakeholder groups.

82-SEPC / Primary Care Research Program

Division: Division of Services and Intervention Research (DSIR)

Description: This program includes studies on the delivery and effectiveness of mental health services within the general health care sector; recognition, diagnosis, management, and treatment of mental and emotional problems by primary care providers; coordination of general medical care with and referrals to mental health specialists; provision of psychiatric emergency services, consultation/liaison psychiatry, and other psychiatry, psychology, and social work services within the general medical care sector; studies that improve understanding of how best to improve care for people with mental disorders and co-occurring physical conditions.


Andrea Beckel-Mitchener

301-443-5288
Molecular, Cellular, & Genomic Neuro Rsch Branch
Neuroscience Center/Room 7187/MSC 9641

73-MCG / Functional Neurogenomics Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The program supports research on the elucidation of gene function and gene regulatory mechanisms in vertebrate and invertebrate model organisms relevant to understanding the genomics components of neuronal development, signal transduction, synaptic plasticity, circadian rhythmicity, drug discovery, and the mechanism of action of therapeutics. Research supported by this program includes studies of DNA regulatory mechanisms; studies of the effects of changes in RNA processing and expression; and investigation of translational processes and molecular mediators responsible for functional changes within specific populations of brain cells.


Susan Borja

301-443-1252
Division of Translational Research
Neuroscience Center/Room 7125/MSC 9632

AD-TSD / Dimensional Measurement and Intervention Program

Division: Division of Translational Research (DTR)

Description: This program supports research to develop and refine measures of basic dimensions of functioning (e.g., fear circuitry, working memory, arousal, emotion regulation) relevant across traditionally defined or perceived posttraumatic psychopathology as well as interventions with dimensional therapeutic targets. Applications responsive to this program should apply emerging knowledge about genetics, brain circuitry and functioning, as well as behavior to aid in characterizing posttraumatic disorders. Further, applications may seek to validate approaches to assessing dysregulated/dysfunctional brain and behavioral functions, structures, connections, and processes that are predictive of symptoms and/or implicated in etiology or persistence of disorder or alternatively predictive of treatment responsiveness.


Linda Brady

301-443-3563
Div. of Neuroscience & Basic Behavioral Science
Neuroscience Center/Room 7204/MSC 9645

73-MCR / Drug Discovery and Clinical Therapeutics Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: This program supports research aimed at designing and developing novel research tools (PET, SPECT, and fMRI imaging ligands); developing therapeutic agents for use in basic and clinical studies and for the treatment of mental disorders; and understand the clinical pharmacologic actions of therapeutic drugs and other treatments at the molecular and cellular level. Supported research includes studies of molecular pharmacology and structural chemistry of CNS receptors, transporters, ion channels, neuropeptides, and neuromodulators; investigations into drug-drug interactions; identification of pharmacological research tools and preclinical drug discovery. The program also supports the National Cooperative Drug Discovery Groups for the Treatment of Mood Disorders (NCDDG-MD). The NCDDG-MD supports public-private partnerships to accelerate the discovery of new mechanisms of action for therapeutics used for mood disorders; to increase the availability of pharmacologic research tools for basic and clinical research; and to facilitate the development and validation of models to evaluate novel therapeutics in mood disorders.


Emile Brouwers

240-627-3863
Division of AIDS Research
BG 5601FL/Room 9E21/MSC 9831

9A-ASP / HIV Prevention Science Branch

Division: Division of AIDS Research (DAR)

Description: This Branch supports the discovery, development, and testing of novel interventions to advance HIV prevention and care, with specific interest in the charterization of emerging populations and communities at high risk for HIV infection. The research identifies potentially modifiable risk factors for HIV acquisition in these populations, and develops effective interventions to prevent or reduce the transmission of HIV/AIDS and sexually transmitted diseases. Major research foci are the development of integrated biomedical-behavioral interventions for prevention and care and sustained behavior change to reduce incident HIV infections. The Branch encourages basic behavioral and social science research to advance the development of innovative interventions, research to test the efficacy of novel behavioral and/or integrated behavioral and biomedical interventions, and research to translate and operationalize findings from these basic studies. Also included in this Branch are studies on the neurobehavioral and neuropsychiatric consequences on HIV infection and the associated antiretroviral therapy and neuroscience-related factors that may affect the risk for acquiring HIV.

9A-ASPC / Clinical Neuroscience of HIV Infection Program

Division: Division of AIDS Research (DAR)

Description: This program supports clinical neuroscience research on infants, children, adolescents, and adults who are HIV infected or at risk for acquiring HIV. Specifically, the program invites studies addressing neurocognitive, behavioral, and psychiatric consequences of living with HIV across the lifespan as well as factors that may modify the risk of these consequences. In addition, the program encourages studies that utlilize neuroscience and basic behavioral research based approaches to address ways to optimize HIV prevention.

9A-ASPI / Structural and Community Factors in HIV Prevention Program

Division: Division of AIDS Research (DAR)

Description: This program fosters collaborative research strategies that emphasize structural changes at multiple intervention levels (e.g., individual, couples, family, social network, community, society (media and policy), and orgnizational complexity). Examples of the types of research supported by the program include: prevention studies that evaluate the determinants of initial behavioral change and reinforcements for long-term behavior change; and global collaboration in HIV/sexually transmitted disease (STD) prevention research.


Bettina Buhring

301-443-1178
Behavioral Science & Integrative Neuro Rsch Branch
Neuroscience Center/Room 7195/MSC 9637

72-NBM / Substrates of Learning and Memory Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Program supports relevant basic research on the fundamental mechanisms underlying memory and learning from the behavioral, systems, and cellular perspectives in humans and animals. Deficits in memory and learning function are key features of many psychiatric disorders and improving memory and learning ability are important objectives for therapies addressing mental disorders. Areas of interest include: How is memory consolidated? What neural systems support this process? What mechanisms underlie how memories or previously learned phenomena are recalled, forgotten or extinguished? What processes are involved in the reconsolidation of memories?


Mark Chavez

301-443-8942
Division of Translational Research
Neuroscience Center/Room 7126/MSC 9632

A2-AIM / Eating Disorders Research Program

Division: Division of Translational Research (DTR)

Description: This program supports research on the etiology, core features, longitudinal course, and assessment of eating disorders. It also supports studies focusing on the elucidation of risk factors for the onset or recurrence of psychopathology. Intervention development studies grounded in findings from psychopathology are supported as the next step in the translation of basic research to effective treatments.

AK-TAIF / Flws-Adt Psychopathology & Psychosocial Intv Rsch

Division: Division of Translational Research (DTR)

Description: The Division of Translational Research (DTR) Office of Research Training and Career Development supports research training at the predoctoral, postdoctoral, and early investigator level to ensure that highly trained research investigators will be available to address research questions pertinent to mental health and mental illness and thereby to reduce the burden of mental and behavioral disorders. Funding opportunities supported by DTR’s research training and career development offices include institutional (T32, R25) and individual training (F30, F31, F32, R36) and mentored career development (K01, K08, K23, K99/R00) programs.

AK-TN / Research Training and Career Development Program

Division: Division of Translational Research (DTR)

Description: The Division of Translational Research (DTR) Office of Research Training and Career Development supports research training at the predoctoral, postdoctoral, and early investigator level to ensure that highly trained research investigators will be available to address research questions pertinent to mental health and mental illness and thereby to reduce the burden of mental and behavioral disorders. Funding opportunities supported by DTR’s research training and career development offices include institutional (T32, R25) and individual training (F30, F31, F32, R36) and mentored career development (K01, K08, K23, K99/R00) programs.

AK-TNAI1 / Trng-Adt Psychopathology & Psychosocial Intv Rsch

Division: Division of Translational Research (DTR)

Description: The Research Training and Career Development Program supports research training at the pre-doctoral, post-doctoral, and early investigator levels of career development in areas relevant to the focus of the Division. This program supports training in Adult Psychopathology and Psychosocial Intervention Research.

AK-TNGP1 / Training - Geriatrics Research

Division: Division of Translational Research (DTR)

Description: The Research Training and Career Development Program supports research training at the pre-doctoral, post-doctoral, and early investigator levels of career development in areas relevant to the focus of the Division. This program supports training in Geriatrics Research.

AK-TNNS1 / Trng-Adt PathPhys & Biological Intvs Dv Rsch

Division: Division of Translational Research (DTR)

Description: The Research Training and Career Development Program supports research training at the pre-doctoral, post-doctoral, and early investigator levels of career development in areas relevant to the focus of the Division. This program supports training in adult pathophysiology and biological interventions development.

AK-TNSF / Flws-Adt PathPhys and Biological Intvs Dv Rsch

Division: Division of Translational Research (DTR)

Description: The Research Training and Career Development Program supports research fellowships at the pre-doctoral, post-doctoral, and early investigator levels of career development in areas relevant to the focus of the Division. This program supports fellowships in adult pathophysiology and biological interventions development.

AK-TNTS / Training - Traumatic Stress Disorders Research

Division: Division of Translational Research (DTR)

Description: The Research Training and Career Development Program supports research training at the pre-doctoral, post-doctoral, and early investigator levels of career development in areas relevant to the focus of the Division. This program supports training in Traumatic Stress Disorders Research.


James Churchill

301-443-3621
Office of the Director
Neuroscience Center/Room 7171/MSC 9617

1H-TDC / Program in Imaging-related Technology Development

Division: Office of the NIMH Director

Description: The Office of Technology Development and Coordination is charged with managing special projects related to technology development or informatics. This research program is focused on the development of imaging technologies supported by the BRAIN Initiative and/or future related initiatives.


Deborah Colosi

301-605-2275
Division of AIDS Research
248 Redwood Road

9A-ASNK / HIV NeuroAIDS Therapeutics Program

Division: Division of AIDS Research (DAR)

Description: This program supports bench to bedside research for developing novel drug therapies for the treatment of neurologic and neurocognitive complications of HIV infection. The program supports: (1) preclinical to clinical research on existing and novel drug targets; (2) development of novel approaches for delivering drugs, including antiretrovirals to the central nervous system (CNS); and (3) creative and original research that has as its goal the movement of new treatments and therapeutic strategies to the clinic. In addition, the program encourages basic and clinical studies on neurotoxicities related to high active antiretroviral therapy.


Nancy Desmond

301-443-3107
Office of Research Training & Career Development
Neuroscience Center/Room 7186/MSC 9645

73-MCI / Neuroendocrinology and Neuroimmunology Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Neuroendocrinology Program supports fundamental research to elucidate the cellular and molecular mechanisms whereby hormones and hormone receptors, acting through nuclear and membrane receptors, modulate signaling in brain circuits relevant to affect, cognition, and social behavior. The Neuroimmunology Program supports fundamental research to identify mechanisms underlying the effects of immune cells, cytokines, and chemokines on neurodevelopment, signaling cascades, synaptic plasticity, brain circuits, and behaviors related to affect, cognition and social behavior.

7K-TG / Office of Research Training and Career Development

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Research Training and Career Development Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Division. The Office thus supports institutional and individual research training programs, research education programs, and early career development programs in basic neuroscience and human genomics.

7K-TGGR / Training - Human Genomics Research

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Research Training and Career Development Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Division. This program supports research training, research education, and mentored career development award programs in Human Genomics Research.

7K-TGGRF / Fellowships - Human Genomics Research

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Research Training and Career Development Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Division. This program supports fellowships in Human Genomics Research.

7K-TGMC / Trng - Molecular, Cellular, & Genomic Neuro Rsch

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Research Training and Career Development Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Division. This program supports research training, research education, and mentored career development award programs in Molecular, Cellular, and Genomic Neuroscience Research.

7K-TGMCF / Flws - Molecular, Cellular, & Genomic Neuro Rsch

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Research Training and Career Development Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Division. This program supports fellowships in Molecular, Cellular, and Genomic Neuroscience Research.

7K-TGNB / Trng - Behavioral Science & Integrative Neuro Rsch

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Research Training and Career Development Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Division. This program supports institutional training, research education, and mentored career development award programs in Behavioral Science and Integrative Neuroscience Research.

7K-TGNBF / Flws - Behavioral Science & Integrative Neuro Rsch

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Research Training and Career Development Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Division. This program supports fellowships in Behavioral Science and Integrative Neuroscience Research.

7K-TGRM / Roadmap - Intd Health Rsch Trng: Behr, Envr & Biog

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Research Training and Career Development Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Division. This program supports collaborative research training and career development activities, e.g. NIH Common Fund, NIH BRAIN Initiative, the Neuroscience Blueprint, and other trans-Institute programs.


Jamie Driscoll

301-443-5288
Molecular, Cellular, & Genomic Neuro Rsch Branch
Neuroscience Center/Room 7189/MSC 9641

73-MCM / Molecular Pharmacology Research Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: This program supports research aimed at characterizing the molecular properties of novel pharmacological research tools for the study of cells and molecular imaging. Supported research includes studies on the design, synthesis, and characterization of target-selective ligands, the identification and characterization of compounds derived from natural products, molecular modeling and computational chemistry, the isolation and characterization of endogenous ligands, and the development and evaluation of novel chemical delivery systems.

7K-TGMC1 / Trng - Molecular, Cellular, & Genomic Neuro Rsch

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Research Training and Career Development Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Division. This program supports research training, research education, and mentored career development award programs in Molecular, Cellular, and Genomic Neuroscience Research.


Jovier Evans

301-443-1369
Division of Translational Research
Neuroscience Center/Room 7113/MSC 9634

A4-GPT / Neuroscience of Mental Disorders and Aging Program

Division: Division of Translational Research (DTR)

Description: This program supports studies of neurobiological factors and pathways that may influence the risk, presentation, course, and outcome of mental disorders in late life or in relation to the aging process. There is particular interest in supporting research consistent with NIMH’s emphasis on taking a dimensional and trans-diagnostic approach in studies of psychopathology, as articulated in the Institute’s Research Domains Criteria (RDoC) project. Relevant research typically uses the theories and tools of basic and translational neuroscience and related biological sciences to investigate the pathophysiology of mental disorders or dimensions of psychopathology, but also may involve other, more phenotypically oriented methods so as to examine the key variables across multiple levels of analysis. The integration of measures drawn from theories and research on the biological aging process so as to study the interplay of aging with mechanisms of psychopathology is highly encouraged. The studies supported may include middle-aged or younger patients as well as older adults when there is a major focus on questions pertaining to the aging process, such as in research on the trajectories of mental disorders with aging.

A4-GPX / Pharmacologic and Somatic Intervention and Aging Program

Division: Division of Translational Research (DTR)

Description: This program supports experimental and observational studies aimed at developing and testing pharmacologic, neuromodulatory, and other somatic interventions for treating, preventing or promoting recovery from the mental disorders of late life. There is particular interest in supporting studies consistent with NIMH’s emphases on clinical innovation and an experimental therapeutics model for clinical trial investigations. Depending on the intervention questions being posed, approaches for use in acute, continuation, or maintenance phases of treatment might be evaluated. The program includes studies of strategies for long-term maintenance of clinical benefits, relapse prevention and enhancement of function/reduction of disability as well as for acute symptom alleviation. Research on the real-world effectiveness as well as efficacy of interventions is supported. Studies may include middle-aged or younger patients as well as older adults when there is a major focus on questions pertaining to the aging process. This program also supports studies of the correlates, predictors, modifiers, and mediators of the variability in older adults’ response to pharmacologic and somatic interventions so as to advance understanding of the interventions’ mechanisms of action and to promote personalization of care.


Gregory Farber

301-435-0778
Office of Technology Development and Coordination
Neuroscience Center/Room 7162/MSC 9640

1H-TD / Office of Technology Development and Coordination (OTDC)

Division: Office of the NIMH Director

Description: The Office of Technology Development and Coordination (OTDC) is responsible for oversight of all NIMH efforts related to technology development for both intramural and extramural research. This research program is focused on developing new technologies for mental health research.

1H-TDA / Program in Informatics and Technology Development

Division: Office of the NIMH Director

Description: The Office of Technology Development and Coordination (OTDC) is responsible for oversight of all NIMH efforts related to informatics for both intramural and extramural research. This research program is focused on developing informatics technologies and platforms for mental health research.

1H-TDB1 / Prg in Comp, Novel Stat Design and Informatics

Division: Office of the NIMH Director

Description: The Program in Computation, Novel Statistical Design and Informatics supports research to develop tools, computational modeling approaches and activities that facilitate data sharing, data analysis and allow for the integration of neuroscience, molecular, genetic, and imaging data using informatics technologies.


Michele Ferrante

301-435-6782
Behavioral Science & Integrative Neuro Rsch Branch
Neuroscience Center/Room 7202/MSC 9637

72-NBT / Theoretical and Computational Neuroscience Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Program supports research on the development and application of realistic models for the analysis and understanding of brain function. Project areas include empirical and theoretical studies of self-organizing behavior in neuronal systems, mathematical approaches to modeling non-stationary neuronal processes, functional imaging of dynamical processes, and the modeling of all levels of neuronal processing, from single cell activity to complex behaviors.

A2-AIC / Computational Psychiatry Program

Division: Division of Translational Research (DTR)

Description: The overarching goal of this program is to foster a novel biologically-based computational framework to identify and validate biomarkers and novel treatment targets relevant to the prevention, treatment, and recovery of psychiatric disorders. The program supports translational research utilizing computational models for validating RDoC constructs in the clinic. The program is interested in analytical approaches for the prediction of risk and treatment response and the understanding of the pathophysiology underlying mental disorders. Research projects combining mathematical and computational tools with neurophysiological, neuroanatomical, neurochemical and/or neuroimaging techniques are encouraged in order to decipher the function of biological mechanisms implicated in mental disorders.


Michael Freed

301-443-3747
Services Research and Clinical Epidemiology Branch
Neuroscience Center/RMoom7144/MSC 9631

82-SE / Services Research and Clinical Epidemiology Branch

Division: Division of Services and Intervention Research (DSIR)

Description: This Branch plans, supports and administers programs of research, research training, and research infrastructure development, across the lifespan, on all mental health services research issues, including but not limited to: (1) Services organization, delivery (process and receipt of care), and related health economics at the individual, clinical, program, community and systems levels in specialty mental health, general health, and other delivery settings (such as the workplace); (2) Interventions to improve the quality and outcomes of care, including diagnostic, treatment, preventive, and rehabilitation services. (3) Enhanced capacity for conducting services research; (4) The clinical epidemiology of mental disorders across all clinical and service settings; (5) The dissemination and implementation of evidence-based interventions into service settings.


Michelle Freund

301-443-1815
Office of Technology Development and Coordination
Neuroscience Center/Room 7101/MSC 9640

1H-TDB / Program in Neurotechnology

Division: Office of the NIMH Director

Description: The Neurotechnology Program supports basic and applied research and the development of novel tools, technologies and approaches for studying the brain and behavior through circuit analysis, including molecular and genetic approaches as well as novel imaging methods. This includes the development of software (such as informatics tools and resources, tools for analyzing data, etc.) and hardware (including the development of instrumentation and devices); tools, approaches, and activities that facilitate data sharing and allow for the integration of neuroscience, genetic, and imaging data; tools, methods, and techniques for demonstrating neuronal connectivity in humans, either in vivo or in post mortem tissue; and tools and aproaches for non-invasive imaging of functional brain activation at high temporal resolution and sub-millimeter spatial resolution.


Stacia Friedman-Hill

301-443-8458
Division of Translational Research
Neuroscience Center/Room 7172/MSC 9617

B4-TBB / Trajectories of Behavioral Dysregulation Program

Division: Division of Translational Research (DTR)

Description: This program supports research on ADHD, conduct disorder, oppositional defiant disorder, and other disruptive or repetitive behaviors (e.g. Tourette syndrome). A primary emphasis of this program are studies which recognize heterogeneity within traditional clinical disorders and aim to identify predictive and stable biotypes using a Research Domain Criteria (RDoC) research framework that links behavioral patterns and clinical symptoms to functional domains, neural circuits and physiological processes. Studies which explore the interaction of multiple functional domains or circuits are welcome (e.g., studies examining the interplay of cognitive control, reward processes, and/or emotion regulation). Of interest are studies that examine the developmental course of, periods of vulnerability or sensitivity for, or risk processes related to the onset, progression, recurrence, and remission of these disorders and their relevant components. Of particular interest are studies that link brain development with behavioral development, studies that identify biomarkers for disease progression, and studies that test integrative models incorporating biological, behavioral, and environmental/experiential factors.

B4-TBC / Trajectories of Neurocognitive Functioning Program

Division: Division of Translational Research (DTR)

Description: This program supports research on childhood and adolescent psychosis and thought disorders, including genetic phenotypes known to confer risk and prodromal symptomatology. Prospective studies that illuminate mechanisms and trajectories of psychopathology in model animals or humans are welcomed. Of interest are studies that examine the developmental course, periods of vulnerability or sensitivity, or risk processes related to the onset, progression, recurrence, and remission of psychopathology and its relevant components. NIMH strongly encourages use of the Research Domain Criteria (RDoC) research framework to identify circuits and functional domains that are key to the development of psychosis and can serve as predictive biomarkers. Of particular interest are studies that link brain development with behavioral development, studies that identify biomarkers for disease progression, and studies that test integrative models incorporating biological, behavioral, and environmental/experiential factors in the development of psychopathology.

B4-TBM / Trajectories of Mood Dysregulation Program

Division: Division of Translational Research (DTR)

Description: This program supports research on the neurodevelopmental trajectories and mechanisms of mental illness associated with affect regulation, emotion, and stress reactivity, including mood lability, bipolar disorder, borderline personality disorder, and related phenotypes and prodromal symptomatology. Of interest are studies that examine the developmental course of, periods of vulnerability or sensitivity for, or risk processes related to the onset, progression, recurrence, and remission of these disorders and their relevant components. Of particular interest are studies that link brain development with behavioral development; studies that identify biomarkers for disease progression; studies that identify sensitive periods for typical and atypical developmental trajectories; studies that elucidate biomarkers and mechanisms of disease progression; studies delineating mechanisms of sex and gender differences in the development of these phenotypes; and studies that test integrative models incorporating multiple levels of analysis (biological, behavioral and environmental) across multiple RDoC constructs.


Marjorie Garvey

301-443-4491
Division of Translational Research
Neuroscience Center/Room 7175/MSC 9617

B2-MBB / Mechanisms of Biobehavioral and Mood Dysregulation Program

Division: Division of Translational Research (DTR)

Description: The overarching goal of this program is to support research using an experimental medicine approach to foster development of novel strategies for assessment, treatment, and recovery from mental illnesses in children and adolescents. This program supports the development of novel cognitive, behavioral, and other psychosocial interventions. This program also supports studies that administer an evidence-based intervention to investigate the mechanisms of treatment effect and/or to identify biomarkers of treatment response.

B4-TBD / Prevention and Treatment Trials Program

Division: Division of Translational Research (DTR)

Description: This program supports research on the neurodevelopmental trajectories and mechanisms of mental illness associated with affect regulation, emotion, and stress reactivity, including depression, non-suicidal self-injury, suicidal thoughts and behaviors, and related phenotypes in children and adolescents. Of interest are studies that examine the developmental course of, periods of vulnerability or sensitivity for, or risk processes related to the onset, progression, recurrence, and remission of these disorders and their relevant components. Of particular interest are studies that link brain development with behavioral development; studies that identify sensitive periods for typical and atypical developmental trajectories; studies that elucidate biomarkers and mechanisms of disease progression; studies delineating mechanisms of sex and gender differences in the development of these phenotypes; and studies that test integrative models incorporating multiple levels of analysis (biological, behavioral and environmental) across multiple RDoC constructs.


Lisa Gilotty

301-443-3825
Division of Translational Research
Neuroscience Center/Room 7165/MSC 9617

B2-MBA / Research Program on Autism Spectrum Disorders

Division: Division of Translational Research (DTR)

Description: This program supports research designed to elucidate the characterization, pathophysiology, treatment and outcomes of autism and related disorders. Of particular interest are studies that will lead to enhanced phenotyping, a better understanding of mechanisms and underlying neurobiology, validated measures for use as stratification tools or to assess outcomes in response to treatment, and novel treatments and intervention strategies.


Christopher Gordon

240-627-3867
Division of AIDS Research
BG 5601FL/Room 9G19/MSC 9831

9A-ASG / HIV Treatment and Translational Science Branch

Division: Division of AIDS Research (DAR)

Description: This Branch supports research to understand and prevent adverse health outcomes among people living with HIV/AIDS, and encourages the translation and adoption of effective interventions into community-based clinical, treatment, and other settings. Initiatives in this program include the development and testing of theory-driven interventions to improve linkage to HIV care, adherence to medication therapies, and other biobehavioral prevention interventions to reduce HIV transmission, promote healthy lifestyle choices, and reduce high-risk behaviors.

9A-ASGC / Implementation Science Program

Division: Division of AIDS Research (DAR)

Description: This program encourages research to improve the uptake of efficacious interventions, and to inform and enhance the effectiveness and efficiency of interventions in order to maximize community impact. Many interventions are available in the continuum of HIV prevention, HIV testing, and HIV care (e.g., HIV treatment adherence). To maximize public health impact, significant progress is needed to deliver interventions more efficiently and effectively, transfer interventions from one setting or population to another, and to make better informed choices between competing interventions. This gap between research and implementation is impeding success in prevention, care, and treatment programs--both in the number of people reached and effects on health outcomes. Advances are urgently needed to reduce these unknowns and increase the public health impact of HIV/AIDS prevention, treatment, and care services.

9A-ASGP / HIV Care Engagement and Secondary Prevention Program

Division: Division of AIDS Research (DAR)

Description: This program supports research to understand and address the determinants of prevention and care outcomes for people living with HIV (PLWH). Specifically, this program supports research to address factors that impede the uptake and effectiveness of prevention and care strategies for PLWH, as well as strategies to understand and harness factors that facilitate prevention and care for PLWH.


Margaret Grabb

301-443-3563
Office of Intd Rsch and Scientific Technology
Neuroscience Center/Room 7203/MSC 9645

7T-SB / Small Business Innovation Research and Small Business Technology Transfer Programs

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: In this Division, the SBIR and STTR programs support research and the development of tools related to basic brain and behavioral science, genetics, and drug discovery and development relevant to the mission of the NIMH. Such tools include: software (such as informatics tools and resources and tools for analyzing data); hardware (such as the development of instrumentation or devices); wetware (such as the use of iRNAs or other bioactive agents as research tools or molecular imaging agents or genetic approaches to label neural circuits or modify circuit functions); and drug discovery related technologies such as high throughput screening (HTS) or computational pharmacology approaches.

7T-ST / Small Business Technology Transfer Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: In this Division, the SBIR and STTR programs support research and the development of tools related to basic brain and behavioral science, genetics, and drug discovery and development relevant to the mission of the NIMH. Such tools include: software (such as informatics tools and resources and tools for analyzing data); hardware (such as the development of instrumentation or devices); wetware (such as the use of iRNAs or other bioactive agents as research tools or molecular imaging agents or genetic approaches to label neural circuits or modify circuit functions); and drug discovery related technologies such as high throughput screening (HTS) or computational pharmacology approaches.

AT-BI / Sm Bus Innovation Rsch & Sm Bus Tech Trns Program

Division: Division of Translational Research (DTR)

Description: The Small Business Innovation Research (SBIR) Program supports research and development by small businesses of innovative technologies that have the potential to succeed commercially or to provide significant societal benefits. The Small Business Technology Transfer (STTR) Program has the same objectives but requires academic research involvement.

B2-MBP / Molecular Processes, Biomarkers, and Novel Pharmacological Agents Program

Division: Division of Translational Research (DTR)

Description: This program supports research leading to the development of novel pharmacologic and device-based treatments for childhood-onset mental disorders. Of interest are research to evaluate the molecular and circuit-base targets of these interventions, to optimize dosing, to evaluate safety and tolerance, and to evaluate the association between target engagement and the effect on symptoms or functional domains. Also of interest are the development of reliable and stable biomarkers of pediatric approved drug and device-based interventions to provide missing information highly needed in the field on the central targets and mechanisms; indicators of treatment response or drug safety; and to biologically identify subjects that would best respond to the intervention for stratification purposes.

BT-BU / Sm Bus Innovation Rsch and Sm Bus Tech Trns Prg

Division: Division of Translational Research (DTR)

Description: The Small Business Innovation Research (SBIR) Program supports research and development by small businesses of innovative technologies that have the potential to succeed commercially or provide significant societal benefits. The Small Business Technology Transfer (STTR)Program has the same objectives, but requires academic research involvement.


Gregory Greenwood

240-669-5532
Division of AIDS Research
BG 5601FL/Room 9G13/MSC 9831

9A-ASGT / Socioecological Approaches to HIV Prevention Program

Division: Division of AIDS Research (DAR)

Description: To advance HIV prevention, this program will encourage research to understand and intervene on the individual, contextual, systemic, and structural factors that can facilitate or impede optimal access and use of effective HIV prevention strategies. Studies are needed to develop and test effective models to increase identification of HIV-infected individuals, and advance linkage to care in order to improve HIV care continuum outcomes. Research can be conducted in U.S. domestic settings or international settings that have high HIV incidence or prevalence, with an emphasis on approaches likely to have broad impact. Studies are also needed that investigate the optimal combination of interventions, including multi-level approaches, to ensure the most effective uptake and effectiveness of HIV prevention, including HIV-testing and other known effective interventions.


Adam Haim

301-435-3593
Clinical Trials Operations and Biostat Br
Neuroscience Center/Room 7148/MSC 9649

8T-SB / Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs

Division: Division of Services and Intervention Research (DSIR)

Description: The Small Business Innovation Research (SBIR) Program supports research and development by small businesses of innovative technologies that have the potential to succeed commercially or provide significant societal benefits. The Small Business Technology Transfer (STTR) Program has the same objectives but requires academic research involvement.


Lauren Hill

301-443-2638
Office of Research Training & Career Development
Neuroscience Center/Room 7155/MSC 9629

85-TPAS2 / Adt Psychosocial Intvs Research Program

Division: Division of Services and Intervention Research (DSIR)

Description: The psychosocial interventions research program supports research evaluating the effectiveness of psychosocial (psychotherapeutic and behavioral) therapeutic interventions, alone or in combination/sequence, on adults’ clinical course and functioning across domains (e.g., social/interpersonal, vocational functioning). In particular, research on interventions in perinatal periods will be included in this program.

85-TPCS1 / Child & Adl Psychosocial Intvs Rsch Program

Division: Division of Services and Intervention Research (DSIR)

Description: The psychosocial interventions research program supports research evaluating the effectiveness of psychosocial (psychotherapeutic and behavioral) therapeutic interventions, alone or in combination/sequence, on children's and adolescents' mental and behavior disorders, including acute and longer-term therapeutic effects on clinical course and functioning across domains (e.g., school, family, peer functioning) with special focus on young children and early treatment.

8K-RT / Office of Research Training and Career Development

Division: Division of Services and Intervention Research (DSIR)

Description: This Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in areas relevant to the focus of the Division. This includes research training and early career development in: research related to clinical trials (including preventive, treatment and rehabilitative interventions alone and/or in combination); effectiveness research; adapting interventions and demonstrating their utility in broad populations (ethnic and racial groups, comorbid disorders) for various service settings (primary care, schools, public sector); and developing research methodology and analytic procedures related to interventions and services research, clinical epidemiology, health disparities (including rural populations), and the dissemination of evidence-based treatments and research.

8K-RTAT / Training - Adult Treatment & Preventive Intv Rsch

Division: Division of Services and Intervention Research (DSIR)

Description: This Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in areas relevant to the focus of the Division. This program supports training in Adult Treatment and Preventive Intervention Research.

8K-RTCT / Training - Child Treatment & Preventive Intv Rsch

Division: Division of Services and Intervention Research (DSIR)

Description: This Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in areas relevant to the focus of the Division. This program supports training in Child Treatment and Preventive Intervention Research.

8K-RTFA / Flws - Adt Trt & Preventive Intv Rsch

Division: Division of Services and Intervention Research (DSIR)

Description: This Office supports research training at the pre-doctoral and post-doctoral level of career development in areas relevant to the focus of the Division. This program supports fellowships in Adult Treatment and Preventive Intervention Research.

8K-RTFC / Flws – Child & Adl Trt & Preventive Intv Rsch

Division: Division of Services and Intervention Research (DSIR)

Description: This Office supports research training at the pre-doctoral and post-doctoral level of career development in areas relevant to the focus of the Division. This program supports fellowships in Child and Adolescent Treatment and Preventive Intervention Research.

8K-RTFS / Flws- Services Rsch & Clinical Epidemiology

Division: Division of Services and Intervention Research (DSIR)

Description: This Office supports research training at the pre-doctoral and post-doctoral level of career development in areas relevant to the focus of the Division. This program supports fellowships in Services Research and Clinical Epidemiology.

8K-RTSE / Training - Services Rsch and Clinical Epidemiology

Division: Division of Services and Intervention Research (DSIR)

Description: This Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in areas relevant to the focus of the Division. This program supports training in Training in Services Research and Clinical Epidemiology.

8K-RTTA / Trng - Adt Trt & Preventive Intv Rsch

Division: Division of Services and Intervention Research (DSIR)

Description: This Office supports research training at the pre-doctoral, post-doctoral, and early stage investigator level of career development in areas relevant to the focus of the Division. This program supports training in Adult Treatment and Preventive Intervention Research.

8K-RTTC / Trng - Child Trt & Preventive Intv Rsch

Division: Division of Services and Intervention Research (DSIR)

Description: This Office supports research training at the pre-doctoral, post-doctoral, and early stage investigator level of career development in areas relevant to the focus of the Division. This program supports training in Child Treatment and Preventive Intervention Research.

8K-RTTS / Trng - Services Rsch & Clinical Epidemiology

Division: Division of Services and Intervention Research (DSIR)

Description: This Office supports research training at the pre-doctoral, post-doctoral, and early stage investigator level of career development in areas relevant to the focus of the Division. This program supports training in Training in Services Research and Clinical Epidemiology.


Mi Hillefors

301-443-1692
Division of Translational Research
Neuroscience Center/Room 7123/MSC 9632

A3-NSET / Translational Therapeutics Program

Division: Division of Translational Research (DTR)

Description: This program supports research that seeks to identify and validate targets for intervention development; assess mechanisms of action of putative interventions; identify and validate biomarkers of disease progression and treatment response; demonstrate and evaluate target engagement of proposed interventions; and evaluate their clinical efficacy. The overall goal is to facilitate the development of novel treatments for major mental disorders in adults (ages 18+) and clinical dimensions of psychopathology associated with these disorders.

A3-NST / Neuroinflammation & Clinical Therapeutics Rsch Prg

Division: Division of Translational Research (DTR)

Description: This program supports research seeking to develop a mechanistic understanding of how interactions between the immune system and the central nervous system contribute to psychopathology in adults (ages 18+). Experimental approaches may include genetic analysis, inflammatory pathways, animal models, neuroimaging, and electrophysiology.


Jeymohan Joseph

240-627-3869
Division of AIDS Research
BG 5601FL/Room 9G20/MSC 9831

9A-ASN / HIV Neuropathogenesis, Genetics, and Therapeutics Branch

Division: Division of AIDS Research (DAR)

Description: This Branch supports an integrated program of studies to elucidate the pathophysiology and genetic factors contributing to HIV-associated neurologic and neurocognitive dysfunction. The Branch also supports the development of novel therapeutic strategies derived from HIV neuropathogenesis research to mitigate central nervous system complications of HIV infection.

9A-ASNE / Eradication HIV-1 frm CNS/Myeloid Reservoirs Prg

Division: Division of AIDS Research (DAR)

Description: This program supports innovative research in five areas: (1) basic research to identify and characterize persistent/latent HIV-1 in cells derived from the central nervous system (CNS), such as macrophages, microglia, and/or astrocytes, in the setting of suppressive anti-retroviral therapy; (2) basic research to determine the mechanisms involved in the temporal establishment, maintenance, and resurgence of persistent/latent HIV-1 in the CNS, in relationship to the timing of antiretroviral therapy; (3) development of physiologically relevant animal models and CNS-based cellular assays that recapitulate HIV-1 persistence and latency in the presence of effective highly active antiretroviral therapy (HAART); (4) feasibility assessments of current and emerging eradication approaches to have successfully reactivated persistent HIV from CNS-derived cells such as macrophages, microglia and astrocytes; and (5) assessment of CNS toxicity and adverse impact of current and emerging eradication strategies.

9A-ASNG / Viral/Host Genetics Program

Division: Division of AIDS Research (DAR)

Description: This program supports basic and clinical research to determine the viral and host genetic factors regulating the development of neurologic and neuropsychiatric complications caused by HIV in the developed and developing world. The program encourages use of state-of-the-art genetic approaches (e.g., transcriptomics, phenomics, epigenomics, whole genome association studies, next generation sequencing, exome sequencing, and system biology) to identify and validate viral and host genetic factors that influence the pathophysiology of HIV-associated neurocognitive disorders (HAND).

9A-ASNP / Mechanisms of HIV Neuropathogenesis Program

Division: Division of AIDS Research (DAR)

Description: This program supports basic research to determine the mechanisms of neuropathogenesis caused by HIV and associated opportunistic and co-infections in both the developed and developing world. The program encourages HIV neuropathogenesis research that utilizes state-of-the art approaches derived from the fields of molecular biology, physiology, virology, neurology, immunology, neuropsychology and epidemiology.


Denise Juliano Bult

301-443-1638
Services Research & Clinical Epidemiology Branch
Neuroscience Center/Room 7143/MSC 9631

82-SEDRJ / Dissemination & Implementation Rsch Prg

Division: Division of Services and Intervention Research (DSIR)

Description: This program includes studies in specialty mental health and community settings that will contribute to the development of a sound knowledge base on the effective transmission of mental health information to multiple stakeholders and of the process by which efficacious interventions can be adopted within clinical settings. Research on dissemination will address how information about mental health care interventions is created, packaged, transmitted, and interpreted among a variety of important stakeholder groups.

82-SEHD / Disparities in Mental Health Services Research Program

Division: Division of Services and Intervention Research (DSIR)

Description: This program plans, stimulates, disseminates, and supports research on the complex factors that influence disparities in mental health services, particularly across special population groups such as racial and ethnic groups, as well as women and children, and persons living in rural and frontier areas. The program addresses care delivered in a variety of settings such as the specialty mental health sector, the general medical sector, and community settings (such as schools).

82-SEMS / Systems Research Program

Division: Division of Services and Intervention Research (DSIR)

Description: Supports studies on organization, coordination, and collaboration of mental health and related services both within and across care settings in order to improve mental health outcomes and prevent or treat co-occurring substance abuse, physical problems, and other behavioral health disorders. Service sectors of interest include: the criminal justice system, housing and other social services, community support, post-trauma services, and adult autism services.


Susannah Kamath

240-627-3861
Division of AIDS Research
BG 5601FL/Room 9E26/MSC 9831

9A-ASPA / Infant, Child, and Adolescent HIV Prevention Program

Division: Division of AIDS Research (DAR)

Description: This program supports research to advance the understanding of how best to prevent the acquisition of HIV infection in vulnerable infants, children, and adolescents. The program also supports research to understand, prevent, and address adverse health outcomes among youth living with HIV. Research in these areas can be at the level of the individual, family, group, or community, both domestically and internationally.


Susan Koester

301-443-3563
Extramural Research Programs
Neuroscience Center/Room 7205/MSC 9645

74-GRT1 / Translational Genomics Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: This program supports research that explores the functional role of genomics, beyond the level of DNA variation, in the development of mental disorders. Emphasis in the areas of epigenomics, non-coding functional elements, and integration of multidimensional data to computationally and functionally validate potential underlying networks that lead to disease.


Charlene Le Fauve

301-435-4582
Office for Research on Disparities and Global MH
Neuroscience Center/Room 6214/MSC 9659

15-SG / Office for Research on Disparities and Global Mental Health (ORDGMH)

Division: Office of the NIMH Director

Description: The Office for Research on Disparities and Global Mental Health provides scientific leadership and guidance to the planning, development, implementation and evaluation of biomedical research relevant to mental health disparities within and outside of the United States. The Office's combined focus on local and global mental health disparities reflects an understanding of how the rapid movements of populations, global economic relationships, and communication technologies have created more permeable borders and new forms of interconnectedness among nations and people. The office supports research that: (1) promotes strategies to reduce mental health disparities and increase attention to women's mental health, the mental health needs of minority and underserved populations, and global mental health; (2) supports programs of basic and applied research on the mental health of women, racial and ethnic minority, rural and underserved populations; (3) supports the development and maintenance of a diverse, mutldisciplinary mental health research workforce within the United States; (4) supports capacity-building, research infrastructure development, and research mentoring in order to develop a multidisciplinary mental health research workforce in low- and middle-income countries; (5) provides increased emphasis on variations in incidence, prevalence, and course of mental disorders and access to care across diverse populations using a global perspective.

15-SGD / Mental Health Disparities Research Program

Division: Office of the NIMH Director

Description: This research program supports research aimed at reducing mental health disparities and increasing attention to women's mental health, and the mental health needs of minority and underserved populations. Areas of interest include variations in incidence, prevalence, and course of mental disorders and access to care across diverse populations, research focusing on the critical roles of context and socioeconomic status on the development of neuropsychiatric disorders, and strategies for measuring mental health disparities.


Thomas Lehner

301-443-1706
Office of Genomics Research Coordination
Neuroscience Center/Room 7201/MSC 9643

1J-GR / Office of Genomics Research Coordination (OGRC)

Division: Office of the NIMH Director

Description: The Office of Genomics Research Coordination (OGRC) facilitates and promotes research to elucidate genomic risk factors that underlie mental disorders and oversees the NIMH efforts in this area for the extra and intramural program.

1J-GRR / Genomics Repository Resources Program

Division: Office of the NIMH Director

Description: This research program develops and promotes NIMH genomics-related resources and corsortia.


Kristina Mclinden

301-443-3187
Division of Translational Research
Neuroscience Center/Room 7115/MSC 9617

AK-TNAI2 / Trng-Adt Psychopathology & Psychosocial Intv Rsch

Division: Division of Translational Research (DTR)

Description: The Research Training and Career Development Program supports research training at the pre-doctoral, post-doctoral, and early investigator levels of career development in areas relevant to the focus of the Division. This program supports training in Adult Psychopathology and Psychosocial Intervention Research.

AK-TNGP2 / Training -Geriatrics Research

Division: Division of Translational Research (DTR)

Description: The Research Training and Career Development Program supports research training at the pre-doctoral, post-doctoral, and early investigator levels of career development in areas relevant to the focus of the Division. This program supports training in Geriatrics Research.

AK-TNNS2 / Trng-Adt PathPhys and Biological Intvs Dv Rsch

Division: Division of Translational Research (DTR)

Description: The Research Training and Career Development Program supports research training at the pre-doctoral, post-doctoral, and early investigator levels of career development in areas relevant to the focus of the Division. This program supports training in adult pathophysiology and biological interventions development.


David Mcmullen

301-451-0180
Division of Tranlsational Research
Neuroscience Center/Room 7129/MSC 9617

A3-NSNM / Neuromodulation and Neurostimulation Program

Division: Division of Translational Research (DTR)

Description: This program supports research that seeks to refine existing neurostimulation and neuromodulation interventions; identify and validate targets for novel interventions using such modalities; assess mechanisms of action of existing and putative neuromodulation interventions; and identify and validate biomarkers of disease progression and treatment response. The overall goal is to advance neurotherapeutics for major mental disorders and clinical dimensions of psychopathology (RDoC) associated with these disorders.


Douglas Meinecke

301-443-6767
Division of Translational Research
Neuroscience Center/Room 7124/MSC 9639

A3-NSM / Molecular and Cellular Pathophysiology Program

Division: Division of Translational Research (DTR)

Description: This program supports research directed toward developing a mechanistic understanding of the neural bases of mental disorders in adults (ages 18+) at the molecular and cellular level. The goal is to reveal how direct and/or indirect alterations of molecular pathways contribute to the genesis of symptoms and alterations in dimensional constructs (RDoC) of mental disorders. Appropriate applications will employ a diverse range of technical and methodological approaches in an effort to elucidate how interactions between genetic mechanisms and molecular pathways contribute to the etiology, pathogenesis and phenotypic expression of adult mental disorders and how this knowledge may be exploited for the identification and development of novel therapeutic targets.

A3-NSS / Central-Peripheral Interactions Pathophysiology Program

Division: Division of Translational Research (DTR)

Description: This program supports research directed towards understanding how dysfunction in neural systems and other biological systems contribute to psychopathology and dimensional behavioral disorders in adults (ages 18+). There is an emphasis on the functional relationship between interacting neural circuitries and peripheral biological systems and processes. Key questions include how these interactions contribute to symptoms or dimensional constructs (RDoC) that are characteristic of mental disorders and how such interactions can be exploited for translational therapeutic development. Experimental approaches may include genetic analysis, endocrine function, bioenergetics, animal models, neuroimaging, and molecular approaches.


Enrique Michelotti

301-443-5415
Div. of Neuroscience & Basic Behavioral Science
Neuroscience Center/Room 7179/MSC 9645

73-MCB / Chemical Optimization Resource Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The program supports chemical optimization projects developed in conjunction with the NIH Blueprint Neurotherapeutics Program contract resources.


Sarah Morris

301-443-9233
Division of Translational Research
Neuroscience Center/Room 7122/MSC 9625

A2-AI / Psychopathology, Behavioral Dysregulation, and Measurement Development Research Program

Division: Division of Translational Research (DTR)

Description: This branch promotes translational research that is directed toward advancing discoveries from basic (non-clinical) research into improved understanding of clinical problems and the development and testing of new behavioral, cognitive, and psychosocial interventions. The goals of this work include improving our understanding of how the development, onset, and course of adult psychopathology may be explained by dysfunction in fundamental neurobehavioral mechanisms such as emotion, cognition, motivation and social processes. The branch supports research on modifiable risk and protective factors for psychopathology and on the use of modern psychometric techniques to guide refinements in the conceptualization and assessment of disorder. Emphasis is placed on studies that combine approaches from neuroscience and behavioral science to produce integrative models of risk, disorder, and recovery, consistent with the Research Domain Criteria framework. http://www.nimh.nih.gov/research-priorities/rdoc/index.shtml

A2-AIA / Affective Processes and Anxiety Disorders Research Program

Division: Division of Translational Research (DTR)

Description: This program supports translational research on the etiology and course of anxiety disorders, including research aimed at an improved understanding of the similarities and differences in psychopathology among different anxiety disorders. It also encourages research on emergent preventive and treatment interventions. Research on affective processes related to anxiety and/or fear may be conducted from a behavioral or integrative perspective. Topic areas of research include emotion and emotion regulation, fear and threat related processes, motivation, cognition, and social and affective processes that contribute to an enhanced understanding of risks for disorders and to new approaches for preventive or treatment interventions.

A2-AID / Mood and Sleep Disorders Research Program

Division: Division of Translational Research (DTR)

Description: This program supports research on the etiology, core features, longitudinal course, assessment of, and interventions for mood and arousal/regulatory psychopathology as outlined in the NIMH Research Doman Criteria (RDoC) initiative that emphasizes a mechanistic, dimensional approach to psychopathology. RDoC domains directly relevant to mood psychopathology include Negative Valence, Positive Valence, Cognitive Systems, and Social Processes. Arousal/regulatory systems research is a related core concept in the RDoC framework. The program supports research directed toward the elucidation of risk and protective processes underlying the onset or recurrence of psychopathology. Intervention development studies grounded in dimensional, mechanistic findings are supported to accelerate the translation of basic research into effective preventive and treatment interventions that have compelling public health impact in real-world clinical and community settings.

A2-AISZ / Schizophrenia Spectrum Disorders Research Program

Division: Division of Translational Research (DTR)

Description: This program supports research into the origins, onset, course, and outcome of schizophrenia spectrum disorders and other psychotic psychopathology. The goals of the program are to discover mechanisms that transform vulnerability characteristics into active illness; to identify valid markers of illness onset; to develop psychometrically sound methods for assessing the cognitive, affective, and behavioral response systems believed to underpin clinical symptoms and functional impairments; and ultimately to channel scientific findings from each of these areas into the development of effective methods of mental illness prevention, treatment, and rehabilitation.


Laurie Nadler

301-443-5288
Molecular, Cellular, & Genomic Neuro Rsch Branch
Neuroscience Center/Room 7184/MSC 9641

73-MCN / Neuropharmacology Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: This program supports research aimed at understanding the cellular and molecular mechanisms of action of psychotherapeutic agents in vitro and in vivo and identifying novel targets for therapeutic intervention in the treatment of mental disorders. Supported research includes studies of the regulation of CNS receptors, transporters, ion channels, neuropeptides, and neuromodulators; investigations into sites and mechanism of action, pharmacokinetics, and effects of psychoactive agents in the brain and other biological systems; and studies on the action of chronic psychoactive drugs on gene expression and function.


George Niederehe

301-443-9123
Division of Translational Research
Neuroscience Center/Room 7131/MSC 9634

A4-GP / Geriatrics and Aging Processes Research Branch

Division: Division of Translational Research (DTR)

Description: The Geriatrics and Aging Processes Research Branch supports programs of research, research mid-career development, and resource development in the etiology, pathophysiology and course of mental disorders of late life, the relationships between aging and mental disorders, the treatment and recovery of persons with aging-related disorders, and the prevention of these disorders and their consequences. In addition to studies focused on older adults and their particular mental health issues and needs, the Branch supports neurodevelopmental investigations of potential risk and resilience factors pertinent to mental disorders and longer-range trajectories of change that may involve examining individuals during earlier phases of the life span, as well. The program encourages collaborative multidisciplinary research programs using the tools of neuroscience, cognitive and affective sciences, and social and behavioral sciences to facilitate the translation of basic science and preclinical research to clinical research. Studies may involve use of brain imaging, genetics and genomics, molecular biology and other evolving neuroscientific methods to investigate factors related to neuropsychiatric disorders of aging, the interaction of these disorders with the processes of aging and neurodevelopment/neurodegeneration, and their assessment and treatment. Disorders of interest include: Mood, anxiety, and personality disorders; psychotic disorders and schizophrenia; psychiatric syndromes and behavioral disturbances in Alzheimer's disease and related dementias; suicide; and neuroregulatory and homeostatic disorders associated with irregularities of sleep, eating, and the menstrual cycle.

A4-GPB / Behavioral Science of Mental Disorders and Aging Program

Division: Division of Translational Research (DTR)

Description: This program supports studies of behavioral and psychosocial factors and processes that may influence the risk, presentation, course, and outcome of mental disorders in late life or in relation to the aging process. There is particular interest in supporting research consistent with NIMH’s emphasis on taking a dimensional and trans-diagnostic approach in studies of psychopathology, as articulated in the Institute’s Research Domains Criteria (RDoC) project. Relevant research typically uses the theories and tools of the social and behavioral sciences, clinical geropsychology, and cognitive and affective science to assess key psychosocial variables, but also may involve neurobiological components so as to examine these constructs across multiple levels of analysis. The integration into the research of indices of the aging process, including concepts and measures drawn from psychological and social theories of adult development and aging, is highly encouraged. Studies may include middle-aged or younger patients as well as older adults when there is a major focus on questions pertaining to the aging process, such as in research on the trajectories of mental disorders with aging.

A4-GPS / Psychosocial Intervention and Aging Program

Division: Division of Translational Research (DTR)

Description: This program supports experimental and observational studies aimed at developing and testing behavioral and psychosocial interventions for the treatment, prevention, or rehabilitation of the mental disorders of late life. There is particular interest in supporting studies consistent with NIMH’s emphases on clinical innovation and an experimental therapeutics model for clinical trial investigations. Depending on the intervention questions being posed, approaches for use in acute, continuation, or maintenance phases of treatment might be evaluated. The program includes studies of strategies for long-term maintenance of clinical benefits, relapse prevention and enhancement of function/reduction of disability as well as for acute symptom alleviation. Research on the real-world effectiveness as well as efficacy of interventions is supported. Studies may include middle-aged or younger patients as well as older adults when there is a major focus on questions pertaining to the aging process. This program also supports studies of the correlates, predictors, modifiers, and mediators of variability in older adults’ response to behavioral and psychosocial interventions so as to advance understanding of the interventions’ mechanisms of action and to promote personalization of care.


David Panchision

301-443-5288
Molecular, Cellular & Genomic Neuro Rsch Br
Neuroscience Center/Room 7189/MSC 9641

73-MCD / Developmental Neurobiology Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: This program supports fundamental research on the mechanisms of nervous system development, with emphasis on cortical and subcortical circuitry that is affected in mood, emotion, cognition, and in mental illness. This program is founded upon substantial evidence that subtle alterations in neural circuitry during critical periods in brain development underlie the etiologies of several neuropsychiatric disorders.


Jane Pearson

301-443-3598
Adult Treatment & Prv Intervention Rsch Branch
Neuroscience Center/Room 7133/MSC 9635

85-TPP / Preventive Interventions Rsch Prg

Division: Division of Services and Intervention Research (DSIR)

Description: Areas of program responsibility include studies evaluating the effectiveness of preventive interventions, including those designed to reduce the occurrence of mental disorders, dysfunctions and related problems within asymptomatic and subclinical populations and those related to treatment (such as prevention of relapse, recurrence, inappropriate resource use) or side effects in children, adolescents and adults.

85-TPSP / Interventions to Prevent Suicide Rsch Prg

Division: Division of Services and Intervention Research (DSIR)

Description: The portfolio includes youth and adult-related interventions to reduce suicide ideation, attempts and deaths, ranging from exploratory/feasibility studies to effectiveness research. Enhanced approaches to detection, screening, assessment, intervention, follow-up/relapse prevention, as well as types of prevention (universal, selected, indicated) are included. Intervention efforts that address the potential scope of suicide burden (ideation, attempts and/or deaths) or related outcomes (other sources of mortality; functioning) in particular settings, or communities, are encouraged.


Denise Pintello

301-451-1481
Services Research & Clinical Epidemiology Branch
Neuroscience Center/Room 7142/MSC 9631

82-SECH / Child and Adolescent Services Research Program

Division: Division of Services and Intervention Research (DSIR)

Description: This program includes research on the quality, organization, and content of services for children with mental disorders and their families. The program focuses on child mental health services provided in multiple sectors and settings, such as schools, primary care, child welfare, juvenile justice, and mental health.

82-SEDR / Dissemination and Implementation Research Program

Division: Division of Services and Intervention Research (DSIR)

Description: This program includes studies that will contribute to the development of a sound knowledge base on the effective transmission of mental health information to multiple stakeholders and of the process by which efficacious interventions can be adopted within clinical settings. Research on dissemination will address how information about mental health care interventions is created, packaged, transmitted, and interpreted among a variety of important stakeholder groups.

82-SEDRP / Dissemination & Implementation Rsch Prg

Division: Division of Services and Intervention Research (DSIR)

Description: This program includes studies involving child and adolescent populations and settings that will contribute to the development of a sound knowledge base on the effective transmission of mental health information to multiple stakeholders and of the process by which efficacious interventions can be adopted within clinical settings. Research on dissemination will address how information about mental health care interventions is created, packaged, transmitted, and interpreted among a variety of important stakeholder groups.


Beverly Pringle

301-443-3725
Office for Research on Disparities and Global MH
Neuroscience Center/Room 6219/MSC 9659

15-SGG / Global Mental Health Research Program

Division: Office of the NIMH Director

Description: The program supports research focused on generating the major scientific advances needed to make a significant impact on the lives of people living with neuropsychiatric disorders worldwide. Topics of interest include task-shifting, cross-national influences on neuropsychiatric disorders, cross-national comparisons of treatment delivery models for neuropsychiatric disorders, and factors influencing broad uptake of interventions in a variety of global settings.


Dianne Rausch

240-627-3874
Division of AIDS Research
BG 5601FL/Room 8D20/MSC 9831

9A-AS / Division of AIDS Research (DAR)

Division: Division of AIDS Research (DAR)

Description: Supports research to reduce the incidence of HIV/AIDS worldwide and to decrease the burden of living with HIV/AIDS. DAR-supported research encompasses a broad range of studies that includes basic and clinical neuroscience of HIV infection to understand and alleviate the consequences of HIV infection of the central nervous system (CNS), and basic and applied behavioral science to prevent new HIV infections and limit morbidity and mortality among those infected. DAR places a high priority on interdisciplinary research across multiple populations, including racial and ethnic minorities, over the lifespan. The portfolio on the basic neuroscience of HIV infection includes research to: elucidate the mechanisms underlying HIV-induced neuropathogesis; understand the motor and cognitive impairments that result from HIV infection of the CNS; develop novel treatments to prevent or mitigate the neurobehavioral complications of HIV infection; and, minimize the neurotoxicities induced by long-term use of antiretroviral therapy. Critical approaches to this effort require molecular, cellular, and genetic studies to delineate the pathophysiologic mechanisms that lead to disrupted neuronal function, and to identify potential targets for therapeutic intervention. In addition, eradication of the virus from HIV-infected individuals to achieve a cure or a functional cure is a high priority. The behavioral science research agenda emphasizes developing and testing behavioral interventions that can be effectively integrated with biomedical approaches to significantly impact the epidemic. The behavioral science agenda targets prevention of both transmission and acquisition of HIV, adherence to intervention components to reduce the burden of disease, and studies that address the behavioral consequences of HIV/AIDS. A strong component of integrating behavioral and biomedical approaches is expanding collaboration with other NIH institutes and federal agencies to leverage resources and broaden the impact of this research.


Andrew Rossi

301-443-1576
Behavioral Science & Integrative Neuro Rsch Branch
Neuroscience Center/Room 7192/MSC 9637

72-NBX / Executive Functions Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Program supports basic research on multiple aspects of cognition, and executive functions in particular. Complex categorization processes, action planning/monitoring, decision making, and cognitive control are all areas of significant interest to the NIMH and this program in particular. Higher-level attentional and perceptual processes are important to understand because they are fundamental building blocks of more complex cognitive functions


Matthew Rudorfer

301-443-1111
Adult Treatment & Prv Intervention Rsch Branch
Neuroscience Center/Room 7137/MSC 9635

85-TPAP / Adt Psypharm, Somatic, & Integrated Trt Rsch Prg

Division: Division of Services and Intervention Research (DSIR)

Description: Areas of program responsibility include research involving psychotropic medications (singly or in combination) and somatic treatments of demonstrated efficacy. In addition to established brain stimulation approaches, such as electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS), other nonpharmacologic interventions, such as bright light, physical exercise, and complementary/alternative techniques, for which efficacy has been demonstrated are also of interest. Integrated treatment studies, utilizing combined or sequential treatment approaches to improve long-term outcome and optimize the benefit: risk ratio may entail all efficacious pharmacologic, psychosocial, and somatic interventions.

85-TPAP1 / Adt Psypharm, Somatic, & Integrated Trt Rsch Prg

Division: Division of Services and Intervention Research (DSIR)

Description: Areas of program responsibility include research involving psychotropic medications (singly or in combination) and somatic treatments of demonstrated efficacy. In addition to established brain stimulation approaches, such as electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS), other non-pharmacologic interventions, such as bright light, physical exercise, and complementary/alternative techniques, for which efficacy has been demonstrated are also of interest. Integrated treatment studies, utilizing combined or sequential treatment approaches to improve long-term outcome and optimize the benefit: risk ratio may entail all efficacious pharmacologic, psychosocial, and somatic interventions.

85-TPAS1 / Adt Psychosocial Intvs Research Program

Division: Division of Services and Intervention Research (DSIR)

Description: The psychosocial interventions research program supports research evaluating the effectiveness of psychosocial (psychotherapeutic and behavioral) therapeutic interventions, alone or in combination/sequence, on adults’ clinical course and functioning across domains (e.g., social/interpersonal, vocational functioning). Also included are research projects that relate to ethics in mental health, with support for empirical studies of ethical issues that accompany the conduct of mental disorders research involving human subjects. Topics relevant to this program include ethical issues regarding informed consent, assessing and mitigating risks in human subjects research, and dissemination of research findings.

85-TPCP / Child & Adl Psypharm & Integrated Trt Rsch Prg

Division: Division of Services and Intervention Research (DSIR)

Description: Areas of program responsibility include evaluation of the effectiveness and safety of pharmacological treatments for children and adolescents with mental disorders, and all research that integrates different treatment modalities into combined or sequential interventions, or evaluate the comparative effectiveness of different modalities of treatment.


Judith Rumsey

301-443-9264
Division of Translational Research
Neuroscience Center/Room 7123/MSC 9632

A3-NSI / Brain Circuitry and Dynamics Program

Division: Division of Translational Research (DTR)

Description: This program supports research directed toward developing a mechanistic understanding of the brain bases of mental disorders in adults (ages 18+) at the circuit level, drawing heavily on the use of a wide variety of state-of-the-art neuroimaging and other physiological methods, including, but not limited to, those measuring brain dynamics. Applications will generally employ various neuroimaging and/or electrophysiological measures, often in conjunction with cognitive/behavioral neuroscience methodologies, to elucidate how the relevant neural systems contribute to the etiology, pathogenesis and phenotypic expression of adult mental disorders and relate to outcomes and treatment response.


Agnes Rupp

301-443-6234
Services Research & Clinical Epidemiology Branch
Neuroscience Center/Room 7149/MSC 9649

82-SEDRR / Dissemination & Implementation Rsch Prg

Division: Division of Services and Intervention Research (DSIR)

Description: This program includes studies of research methods development and economic analyses that will contribute to the development of a sound knowledge base on the effective transmission of mental health information to multiple stakeholders and of the process by which efficacious interventions can be adopted within clinical settings. Research on dissemination will address how information about mental health care interventions is created, packaged, transmitted, and interpreted among a variety of important stakeholder groups.

82-SEEC / Financing and Managed Care Research Program

Division: Division of Services and Intervention Research (DSIR)

Description: This program supports research on economic factors affecting the delivery of mental health services including the economic burden of mental illness; financing and reimbursement of public and private mental health services; impact of various forms of managed care and physician payment methods on the cost of mental health care; pharmaco-economics; evaluation of the impact of insurance coverage including mandated coverage and mental health insurance parity on access, cost, and quality; cost-benefit, cost-effectiveness and cost-utility analysis of mental health service interventions; and economic analysis of practice patterns of different mental health providers. The goal of the program is to expand understanding of the role of economic factors in the delivery and use of mental health services and assist in the development of improved mental health financing methods promoting high quality, cost-effective care for people suffering from mental disorders.

82-SEQQ / Methodological Research Program

Division: Division of Services and Intervention Research (DSIR)

Description: Supports studies that involve development, testing, and refinement of methodologies and instruments to facilitate research on services for mentally ill persons, including measures of severity of illness, family burden, social support, quality of care, effectiveness of care, direct and indirect cost of mental disorders, and short-term and long-term outcome measures; studies submitted by statisticians, psychometricians, and other experts in research methodology and scientific data analysis for work on the design, measurement, and statistical challenges inherent in conducting mental health services research.


Christopher Sarampote

301-443-1959
Division of Translational Research
Neuroscience Center/Room 7164/MSC 9617

BK-TK / Research Training and Career Development Program

Division: Division of Translational Research (DTR)

Description: The Division of Translational Research (DTR) Office of Research Training and Career Development supports research training at the predoctoral, postdoctoral, and early investigator level to ensure that highly trained research investigators will be available to address research questions pertinent to mental health and mental illness and thereby to reduce the burden of mental and behavioral disorders. Funding opportunities supported by DTR’s research training and career development offices include institutional (T32, R25) and individual training (F30, F31, F32, R36) and mentored career development (K01, K08, K23, K99/R00) programs.

BK-TKF / Individual Fellowship Opportunities Program

Division: Division of Translational Research (DTR)

Description: The Individual Fellowship Opportunities Program is designed to support research training at the pre-doctoral and post-doctoral career development levels. Research support is provided in areas relevant to the Division of Translational Research (DTR), such as psychosocial stress, child abuse and neglect, neurodevelopmental disorders, and affective regulatory disorders. The primary goal of the program is to provide promising applicants with the training necessary to become productive independent investigators in the area of developmental psychopathology. Training support is provided through the following programs: Individual Pre-doctoral and Post-doctoral Fellowships (F30, F31, F32) Dissertation Research Grants to Increase Diversity (R36)

BK-TKM / Trng – Biomarker & Intv Dv for ChO Ment Dis Rsch

Division: Division of Translational Research (DTR)

Description: The Division of Translational Research (DTR) Office of Research Training and Career Development supports research training at the predoctoral, postdoctoral, and early investigator level to ensure that highly trained research investigators will be available to address research questions pertinent to mental health and mental illness and thereby to reduce the burden of mental and behavioral disorders. Funding opportunities supported by DTR’s research training and career development offices include institutional (T32, R25) and individual training (F30, F31, F32, R36) and mentored career development (K01, K08, K23, K99/R00) programs.

BK-TKT / Trng-Dev Mechanisms and Traj of Psycpath Rsch

Division: Division of Translational Research (DTR)

Description: The Division of Translational Research (DTR) Office of Research Training and Career Development supports research training at the predoctoral, postdoctoral, and early investigator level to ensure that highly trained research investigators will be available to address research questions pertinent to mental health and mental illness and thereby to reduce the burden of mental and behavioral disorders. Funding opportunities supported by DTR’s research training and career development offices include institutional (T32, R25) and individual training (F30, F31, F32, R36) and mentored career development (K01, K08, K23, K99/R00) programs.


Geetha Senthil

301-402-0754
Genomics Research Branch
Neuroscience Center/Room 7200/MSC 9643

1J-GRTS / Genomics Team Science Program

Division: Office of the NIMH Director

Description: This research program contributes to the development of strategies and supports collaborations to advance the field of psychiatric genomics. In addition, this research program focuses on the dissemination and promotion of NIMH-sponsored research on genomics and personalized medicine.

74-GRT2 / Translational Genomics Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: This program supports research that explores the role of genomics in the development of mental disorders. Emphasis in the areas of epigenomics, non-coding functional elements, and integration of multidimensional data to computationally and functionally validate potential underlying networks that lead to disease.


Joel Sherrill

301-443-2477
Child & Adl Trt & Preventive Intv Rsch Branch
Neuroscience Center/Room 7135/MSC 9633

85-TP / Trt & Preventive Intvs Rsch Br

Division: Division of Services and Intervention Research (DSIR)

Description: The Branch plans, supports, and administers programs of research, research training, and research infrastructure development to evaluate the therapeutic benefits of mental health preventive, treatment, and rehabilitative interventions alone and/or in combination, for children, adolescents, and adults. The programmatic focus is broad and inclusive with respect to the heterogeneity of individual characteristics and patient needs, the severity and chronicity of disorders, and the variety of community and institutional settings where interventions are provided. In funding decisions, emphasis is placed on the potential clinical impact of the research activities and on the implications of the research findings for improving community practice and health outcomes. Types of interventions include the full range of behavioral, psychotherapeutic, pharmacologic, and non pharmacologic somatic or alternative interventions, as well as rehabilitation or other adjunctive services, e.g., integrated approaches to chronic mental illness. Outcome measures extend beyond symptom reduction to include short- and long-term assessment of functioning. Other areas of emphasis include the identification of moderators and mediators of intervention effects, and their use to develop and test more targeted and personalized interventions, evaluation of the combined or sequential use of interventions of similar or different modalities (e.g., to extend efficacy among refractory subgroups), determination of the optimal length of treatment, establishment of the utility of continuation or maintenance treatment for prevention of relapse and recurrence, and the evaluation of the long-term impact of efficacious interventions on symptoms and functioning.

85-TPAS / Adult Psychosocial Interventions Research Program

Division: Division of Services and Intervention Research (DSIR)

Description: The psychosocial interventions research program supports research evaluating the effectiveness of psychosocial (psychotherapeutic and behavioral) therapeutic interventions, alone or in combination/sequence, on adults’ clinical course and functioning across domains (e.g., social/interpersonal, vocational functioning).

85-TPCS / Child & Adl Psychosocial Intv Rsch Prg

Division: Division of Services and Intervention Research (DSIR)

Description: The psychosocial interventions research program supports research evaluating the effectiveness of psychosocial (psychotherapeutic and behavioral) therapeutic interventions, alone or in combination/sequence, on children's and adolescents' mental and behavior disorders, including acute and longer-term therapeutic effects on clinical course and functioning across domains (e.g., school, family, peer functioning).


Janine Simmons

301-443-6652
Behavioral Science & Integrative Neuro Rsch Branch
Neuroscience Center/Room 7200/MSC 9637

72-NBA / Affect, Social Behavior and Social Cognition Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Program supports integrative approaches to understanding the fundamental principles governing affect, social behavior, and social cognition in humans and animals. Topic areas include the fundamental mechanisms underlying emotions, mood, agonistic and affiliative behaviors, social communication and social cognition as well as investigations into their regulation and development. The program also supports work on fundamental mechanisms of social information processing.


Chisato Stanfield

301-443-5288
Molecular, Cellular, & Genomic Neuro Rsch Branch
Neuroscience Center/Room 7183/MSC 9641

73-MCT / Signal Transduction Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: This program supports fundamental research on the molecular and cellular substrates of neuronal signaling, the factors that influence the signaling process, and the mechanisms that underlie changes in signaling strength. Research supported by this program include studies of neurotransmitters, signaling cascades, and second messengers systems; studies of compartmentalization, targeting, and trafficking of signaling molecules; studies of pre- and post-synaptic proteins, neurotransmitter transporters, ion channels, and ion pumps; and studies of synaptic growth and synaptic plasticity.


Michael Stirratt

240-627-3875
Division of AIDS Research
BG 5601FL/Room 9G28/MSC 9831

9A-ASBZ1 / Small Business Innovation Research (SBIR) Program and the Small Business Technology Transfer (STTR) Program

Division: Division of AIDS Research (DAR)

Description: The Small Business Innovation Research Program (SBIR) supports research by small businesses to develop innovative technologies with high potential to succeed commercially or to provide significant societal benefit. The Division's Small Business Technology Transfer Program (STTR) pursues the same objectives with academic research involvement. The SBIR and STTR focus within this program is directed toward the development of new preclinical therapeutics to prevent or treat the neurological consequences of HIV infection.

9A-ASGA / Adherence to Treatment and Prevention Program

Division: Division of AIDS Research (DAR)

Description: This program supports scientific research in four domains: (1) adherence to biomedical HIV prevention methods [e.g., pre-exposure prophylaxis (PrEP)]; (2) initiation of antiretroviral therapy when indicated for HIV treatment; (3) adherence to antiretroviral therapy for HIV treatment; and (4) retention in HIV primary medical care. Within these areas, the program supports studies to inform future interventions; develop and test novel interventions, and advance the dissemination and implementation of proven interventions. Intervention research may target individuals, providers, or healthcare systems and policies. The program invites researach conducted in U.S. domestic settings or international settings that have high HIV incidence or prevalence, with an emphasis on approaches likely to have broad impact.


David Stoff

240-627-3876
Division of AIDS Research
BG 5601FL/Room 8D20/MSC 9831

9A-ASBZ / Small Business Innovation Research (SBIR) Program and the Small Business Technology Transfer (STTR) Program

Division: Division of AIDS Research (DAR)

Description: The Small Business Innovation Research Program (SBIR) supports research by small businesses to develop innovative technologies with high potential to succeed commercially or to provide significant societal benefit. The Division's Small Business Technology Transfer Program (STTR) pursues the same objectives with academic research involvement. The SBIR and STTR programs in DAR support research aimed at changing risky behaviors, promoting strategies to reduce HIV transmission, elucidating the pathophysiology of HIV-related neuropsychiatric dysfunction, and investigating processes that influence adherence to treatment in individuals with HIV and mental disorders.

9A-ASF / Fellowship Program

Division: Division of AIDS Research (DAR)

Description: Supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in areas relevant to the focus of the Division. The program includes training both in the basic neuroscience of HIV infections, as well as the behavioral science research agenda.

9A-ASH / Training, Fellowship, and Health Disparities Programs

Division: Division of AIDS Research (DAR)

Description: Health Disparities program, which promotes multidisciplinary research and research training on mental health issues related to HIV/AIDS amoung underrepresented diverse racial/ethnic communities in order to reduce the disproportionate burden ofthe HIV/AIDS epidemic on these populations. The major focus of the disparities program is to: (1) enhance diversity in the AIDS mental health research workforce through research capacity building efforts; and (2) support partnerships through collaborative and integrated programs for academic-research-community linkages and for community-based participatory training and research. These two inter-related programs incorporate experiences in didactics (and other relevant curricula and academic enrichment) and research that encourage translational and interdisciplinary approaches.

9A-ASPQ / Aging and Co-Morbidity HIV Research Program

Division: Division of AIDS Research (DAR)

Description: This program addresses the interaction between HIV/AIDS and aging as well as other co-morbidities. The need for such research is driven by the increasing prevalence of older people infected with or at risk for HIV infection, and by aging-associated neuropsychiatric co-morbidities that affect or are affected by HIV infection. Because co-morbidities and HIV may differentially affect certain underserved vulnerable populations (e.g., people with serious mental illness, homeless, prisoners, diverse racial and ethnic groups), the impact of co-morbidities on HIV-related health disparties is an area of importance. This program fosters interdisciplinary research (including epidemiology, psychology, psychiatry, development, geriatrics, neurobiology) at multiple stages, from basic behavioral through translational, and from local to global.

9A-AST / Training Program

Division: Division of AIDS Research (DAR)

Description: The Research Training and Career Development Program supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in areas relevant to the focus of the Division. This includes research training and early career development in: developing and disseminating effective preventive interventions in domestic and international settings. The primary goal of the training program is to ensure that sufficient numbers of highly trained independent investigators will be available to address the complexities of mental health research in HIVAIDS. The AIDS training programs encourages interdisciplinary and translational research approaches.


Farris Tuma

301-443-9232
Division of Translational Research
Neuroscience Center/Room 7111/MSC 9632

AD-TS / Traumatic Stress Research Program

Division: Division of Translational Research (DTR)

Description: The Traumatic Stress Research Program coordinates research on psychopathology related to trauma, including research on neurobiological, behavioral, cognitive, and other risk and protective factors for psychopathology after traumatic events and the development of interventions for posttraumatic psychopathology. The program also supports research spanning and integrating basic science, clinical practice, and health care system factors regarding mass trauma and violence (e.g., war, terrorism, natural and technological disaster), including translational (basic, clinical, and genomic) research on the mental health consequences of traumatic stress to elucidate the nature, causes, and pathophysiology of posttraumatic psychopathology; the development and testing of interventions to assist victims and survivors at risk for and experiencing posttraumatic psychopathology; and models for delivering care effectively and efficiently across settings, contexts, and populations (e.g., children, adolescents, and adults).


Ashlee Van'T Veer

301-443-3107
Office of Research Training & Career Development
Neuroscience Center/Room 7195/MSC 9645

7K-TGGR1 / Training - Human Genomics Research

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Research Training and Career Development Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Division. This program supports research training, research education, and mentored career development award programs in Human Genomics Research.

7K-TGMC2 / Trng - Molecular, Cellular, & Genomic Neuro Rsch

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Research Training and Career Development Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Division. This program supports research training, research education, and mentored career development award programs in Molecular, Cellular, and Genomic Neuroscience Research.

7K-TGNB1 / Trng - Behavioral Science & Integrative Neuro Rsch

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Research Training and Career Development Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Division. This program supports institutional training, research education, and mentored career development award programs in Behavioral Science and Integrative Neuroscience Research.


Aleksandra Vicentic

301-443-1576
Behavioral Science & Integrative Neuro Rsch Branch
Neuroscience Center/Room 7197/MSC 9637

72-NB / Behavioral Science and Integrative Neuroscience Research Branch

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Branch supports innovative research - including empirical, theoretical and modeling approaches - on cognitive, affective, social, motivational, and regulatory systems and their development across the lifespan in humans, in non-human primates, and in other animals. Research approaches looking at the interaction between and among these major systems is of particular interest.

72-NBB / Regulatory and Systems Neuroscience Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Program supports research in humans and animals on the fundamental principles and mechanisms of biobehavioral regulation (i.e., the interaction of behavioral and biological processes), including the development, organization and function of neural circuits relevant to understanding the normal functioning of a variety of brain structures. Areas of interest include neural basis and regulation of motivation, reward, fear, stress, anxiety, circadian rhythms, sleep, and arousal.


Ann Wagner

301-443-3633
Division of Translational Research
Neuroscience Center/Room 7173/MSC 9617

AD-TSC / Child Traumatic Stress Research Program

Division: Division of Translational Research (DTR)

Description: This program supports research on mental disorders in the context of traumatic stress as well as basic dimensions of functioning (e.g., fear circuitry, working memory, arousal, emotion regulation) relevant to traditionally defined or perceived posttraumatic psychopathology among children and adolescents. This includes studies that examine the developmental course of, periods of vulnerability or sensitivity for, or risk processes related to the onset, progression, recurrence, and recovery from traumatic stress disorders and their relevant components as well as preventive and treatment interventions.

B2-MB / Neurobehavioral Mechanisms of Mental Disorders Branch

Division: Division of Translational Research (DTR)

Description: This branch supports research leading to the development of novel, mechanism-based treatments and preventive interventions for childhood-onset mental disorders. The programs within this branch support research to develop novel cognitive, behavioral, psychosocial, pharmacological, and device-based interventions. The branch also supports the identification of reliable and valid biomarkers useful for stratification of research participants in clinical trials or for use as objective predictors or indicators of treatment response (surrogate endpoints). The development of novel technologies, analytic strategies, and other resources for the characterization of individuals for the purposes of stratification into clinical trials, personalizing treatment, and monitoring response to treatment are of interest, particularly approaches that quantify cognitive, emotional, sensorimotor and biobehavioral processes that are often shared across diagnostic categories. The Autism Research Program is also administered within this branch, and supports a wide range of research on the characterization, pathophysiology, treatment, and outcomes of individuals with autism spectrum disorders and related neurodevelopmental disorders.

B2-MBT / Novel Mechanism-Based Interventions for Mental Disorders Program

Division: Division of Translational Research (DTR)

Description: This program supports the development of novel behavioral, cognitive, and other psychosocial approaches to ameliorate or prevent the emergence of mental disorders in very young children. The program also supports interventions targeting the prodromal or preclinical stages of serious mental illness in children and adolescents, with the aim of altering the trajectory of developmental psychopathology and optimizing outcomes. The overarching goal is to facilitate the translation of emerging basic or clinical science findings into novel interventions. Thus, interventions that target recently-identified mechanisms underlying mental disorders in children and adolescents, and/or factors that confer risk for these disorders, are of particular interest. Highly innovative approaches to intervene on an established mechanism are also of interest, if the novel approach has the potential to significantly improve functional outcomes.


Lois Winsky

301-443-5288
Molecular, Cellular, & Genomic Neuro Rsch Branch
Neuroscience Center/Room 7185/MSC 9641

73-MC / Molecular, Cellular, and Genomic Neuroscience Research Branch

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: This Branch plans, supports, and administers programs of research to elucidate the genetic, molecular, and cellular mechanisms underlying brain development, neuronal signaling, synaptic plasticity, circadian rhythmicity, and the influence of hormones and immune molecules on brain function. Other supported activities are drug discovery, identification of novel drug targets, development of functional imaging ligands, development of imaging probes as potential biomarkers, testing of models for assessing novel therapeutics, and studies of mechanisms of action of therapeutics in animals and humans.

73-MCP / Psychopharmacology Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: This program supports interdisciplinary neuroscience research aimed at identifying molecular and cellular mechanisms underlying the behavioral actions of psychoactive drugs. The program focuses on identifying novel targets (genes, molecules) for therapeutic intervention in mental disorders using appropriate models and measures relevant to neuropsychiatric disorders.


Yong Yao

301-443-6102
Molecular, Cellular, & Genomic Neuro Rsch Branch
Neuroscience Center/Room 7182B/MSC 9641

73-MCA / Assay Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The Assay Program supports implementation of innovative biological, biophysical or cell-based assays for novel biological targets or processes relevant to mental disorders. The program also supports science relevant to several related Common Fund programs: 1) the adaptation and development of scalable assay technologies to explore the underlying biology of novel or poorly characterized members of the Druggable Genome such as G-protein coupled receptors, ion channels, nuclear receptors, and protein kinases (Illuminating the Druggable Genome); 2) gene function studies in collaboration with the NIH Undiagnosed Diseases Program (UDP) to investigate the underlying genetics, biochemistry and pathophysiology of newly diagnosed diseases identified through the UDP; and 3) adoption and validation of novel powerful single cell analysis (SCA) approaches by supporting new collaborations of currently funded R01 investigators with developers of the SCA approaches (Single Cell Analysis).

7D-MLHTS / Mol Libraries & Imaging Roadmap HTS Assay Prg

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The program supports innovative biological, biophysical and cell-based assays for biological targets or processes for which there are limited selective and potent small molecule modulators available to the public. High-throughput screening (HTS)-ready assays of interest to the NIH institutes are selected for implementation within the Molecular Libraries Probe Production Centers Network (MLPCN).

7D-MLRM / Molecular Libraries and Imaging Roadmap Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The program provides infrastructure support and coordination for the NIH Roadmap Molecular Libraries Probe Production Centers Network (MLPCN) and for related technology development projects. The program supports research on biological assay implementation, high throughput screening (HTS) to identify active compounds, synthetic chemistry for probe development, and informatics.

7D-MLRM1 / Molecular Libraries and Imaging Roadmap Program

Division: Division of Neuroscience and Basic Behavioral Science (DNBBS)

Description: The program provides infrastructure support and coordination for the NIH Roadmap Molecular Libraries Probe Production Centers Network (MLPCN) and for related technology development projects. The program supports research on biological assay implementation, high throughput screening (HTS) to identify active compounds, synthetic chemistry for probe development, and informatics.


Steven Zalcman

301-443-1692
Division of Translational Research
Neuroscience Center/Room 7123/MSC 9639

A3-NS / Adult Psychopathology and Psychosocial Intervention Research Branch

Division: Division of Translational Research (DTR)

Description: This branch supports programs of research aimed at understanding the brain basis of mental disorders. Specifically supported are multidisciplinary studies with human and model systems on the genetic, molecular, cellular, circuit, and systems levels of brain function designed to elucidate the pathophysiology of mental disease and to translate these findings to clinical diagnosis, treatment, and prevention strategies. These approaches are applied to the entire spectrum of mental disorders.


Julia Zehr

301-443-1617
Division of Translational Research
Neuroscience Center/Room 6163/MSC 9617

B4-TB / Developmental Trajectories of Mental Disorders Branch

Division: Division of Translational Research (DTR)

Description: This branch supports research on the developmental mechanisms contributing to mental disorders and on developmental trajectories of risk and resilience. Research supported in this branch identifies mechanisms responsible for mental disorders by looking across levels of analysis to specify genetic, neural, behavioral, and environmental components that interact to define etiology of childhood-onset mental disorders. In addition, research supported in this branch identifies trajectories of mental disorders by looking across time (e.g., across developmental stages) at sequential and integrative relationships among genetic, neural, behavioral, and experiential/environmental factors leading to psychopathology or to recovery. Emphasis is on developmental progressions and the identification of early signs, risk factors, predictors, and biological mediators/moderators of continuity or change. During development, risk factors may contribute to a range of psychopathologies, and early indicators of later risk are often dimensional. Thus, the branch supports research that crosses traditional diagnostic categories, consistent with the NIMH RDoC initiative. This branch strongly encourages cross-disciplinary research collaborations. Studies involving human and non-human animals are supported, focusing on development from the prenatal period through adolescence.

B4-TBA / Trajectories of Trauma, Anxiety, and Fear Program

Division: Division of Translational Research (DTR)

Description: This program supports research on the neural mechanisms and trajectories of anxiety disorders and associated disorders of behavioral dysregulation during development. The program supports research on a range of clinical symptoms and phenotypes including anxiety disorders (e.g., generalized anxiety disorder, social anxiety disorder, specific phobias, panic disorder, agoraphobia, separation anxiety disorder, selective mutism), obsessive-compulsive disorder, eating disorders (e.g. anorexia nervosa, bulimia nervosa, binge eating disorder), and related phenotypes and prodromes. Of interest are studies that examine the etiology, neurodevelopmental mechanisms, developmental course of, periods of vulnerability or sensitivity for, or risk processes related to the onset, progression, recurrence, and remission of these disorders and their relevant components. Of particular interest are studies that characterize the developmental trajectories of brain maturation and dimensions of behavior to understand the roots of mental illness; studies that identify sensitive periods for typical and atypical trajectories; studies that elucidate biomarkers and mechanisms of disease progression; studies delineating mechanisms of sex/gender differences in the development of behavioral dysregulation; and studies that test integrative models incorporating multiple levels of analysis and RDoC approaches.

B4-TBX / Integrative Studies of Biology and Behavior Program

Division: Division of Translational Research (DTR)

Description: This program supports research focused on the interrelations among a broad range of risk processes and phenotypes across time and development, with a particular emphasis on the interaction between experience, biological factors, and development. Of particular interest are studies that examine basic behavioral components that span multiple disorders; studies that link biological and behavioral components of normal and abnormal functioning; and studies of early neurodevelopment and behavior, etiology, biomarkers and assessment that are applicable to multiple forms of psychopathology. The program includes, but is not limited to, research on perinatal contributions to neurodevelopment; the long-term effects of experience and the developmental origins of health and disease; the effects of stress and adversity on brain maturation and risk for psychopathology; and the intersection of physiological and brain development.