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Borderline Personality Disorder

Borderline personality disorder is a mental disorder characterized by an ongoing pattern of varying moods, self-image, and behavior. These symptoms often result in impulsive actions and problems in relationships. People with borderline personality disorder may experience intense episodes of anger, depression, and anxiety that can last from a few hours to days. Learn more about borderline personality disorder.

Featured Studies

Featured studies include only those currently recruiting participants. Studies with the most recent start date appear first.

Cognitive Reappraisal Training

Study Type: Interventional
Start Date: July 31, 2021
Location: New York, New York
Eligibility: Ages 18–55, Does Not Accept Healthy Volunteers

Previous work by the study group convinced the study team to pursue development of focused cognitive reappraisal training as a novel approach to treatment of BPD, either as stand-alone treatment or in concert with evidence-based treatments of BPD. The present proposal aims to refine and test a proposed clinical intervention for BPD patients, training in reappraisal-by-distancing, in terms of its ability to influence hypothesized neural and behavioral targets and, once that is established, to demonstrate its ability improve clinically relevant outcome measures.

Mapping Aspects of Psychotherapy in Dialectical Behavior Therapy

Study Type: Interventional
Start Date: October 26, 2020
Location: Amherst, Massachusetts
Eligibility: Ages 18–60, Does Not Accept Healthy Volunteers

Although dialectical behavior therapy (DBT) skills training is effective in the treatment of borderline personality disorder, it contains four skills modules and there is little research to guide their modular application. This study compares the unique effects of two distinct DBT skills training modules, relative to a non-DBT therapy group for adults with borderline personality disorder. Using innovative laboratory-based assessment methods, the proposed study will examine the effects of these conditions on emotional responding and interpersonal functioning, as well as clinical outcomes.

Safety Planning Juvenile Justice

Study Type: Interventional
Start Date: January 1, 2019
Location: Providence, Rhode Island
Eligibility: Ages 12–18, Does Not Accept Healthy Volunteers

This study will examine the feasibility and acceptability of a program designed to conduct safety planning with youth in the juvenile justice system who are at risk for a suicide attempt and/or self-injury and to increase the possibility of them receiving outpatient mental health treatment. After training staff in the intervention, the investigators will pilot test the safety planning intervention and gather information on how well it worked on reducing self-harm, getting families to follow up with referrals for mental health care, and how often they attend treatment.