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Obsessive-Compulsive Disorder (OCD)

Featured Studies

Featured studies include only those currently recruiting participants. Studies with the most recent start date appear first.

  • Enhancing Treatment of Hoarding Disorder With Personalized In-Home Sorting and Decluttering Practice
    Study Type: Interventional
    Start Date: September 1, 2016
    Location: Stanford, California
    Eligibility: Ages 18–65, Accepts Healthy Volunteers

    The proposed study aims to investigate the efficacy of adding in-home decluttering practice to Buried in Treasures Workshop (BIT) facilitated group treatment for hoarding disorder.

  • Neurofeedback for Obsessive-Compulsive Disorder (OCD)
    Study Type: Interventional
    Start Date: July 1, 2015
    Location: New Haven, Connecticut
    Eligibility: Ages 18–65, Does Not Accept Healthy Volunteers

    The aim of this study is to train patients with obsessive-compulsive disorder to control a region of their brain that has been associated with their symptoms. Patients in the experimental group will be given direct feedback regarding activity in this brain area while they are undergoing functional magnetic resonance imaging (fMRI) scanning, and will try to learn to control activity in the region during these feedback sessions. A separate group of patients will be given a control form of feedback that we do not believe can have clinical benefits. Our primary hypothesis is that the neurofeedback training will reduce OCD symptoms more than the control feedback.

  • Overlapping Neural Circuits in Pediatric OCD
    Study Type: Interventional
    Start Date: October 1, 2014
    Location: New York, New York
    Eligibility: Ages 5–17, Accepts Healthy Volunteers

    The purpose of this study is to examine the brain functioning of children and adolescent with OCD before and after treatment with Exposure and Response Prevention (EXRP) therapy.

  • Neural Mechanisms of CBT Response in Hoarding Disorder
    Study Type: Interventional
    Start Date: July 1, 2013
    Location: Hartford, Connecticut
    Eligibility: Ages 20–60, Accepts Healthy Volunteers

    The purpose of this research is to measure changes in brain activity with functional magnetic resonance imaging (fMRI) before and after cognitive-behavioral therapy for compulsive hoarding. Cognitive-behavioral therapy aims to help people change the thoughts and behaviors that maintain symptoms of hoarding. The investigators intend to enroll approximately 80 people with hoarding disorder and 40 people with no psychiatric disorder, between the ages of 20 and 60, for this study. The investigators believe that after treatment there will be changes in the brain activity of individuals with compulsive hoarding.

  • Studying Childhood-onset Behavioral, Psychiatric, and Developmental Disorders
    Study Type: Observational
    Start Date: January 26, 2013
    Location: Bethesda, Maryland
    Eligibility: Ages N/A–99, Does Not Accept Healthy Volunteers

    Background:

    - Many psychiatric, behavioral, and developmental disorders are genetic. This means that they tend to run in families. Some begin in childhood, while others do not appear until adulthood. Researchers want to look at people of all ages who have these disorders that started in childhood. They will also look at relatives of people with these disorders. This information will allow doctors to learn more about childhood behavioral problems and how they are inherited. It may also help doctors treat those disorders.

    Objectives:

    - To study the onset and treatment of childhood behavioral, psychiatric, and developmental disorders.

    Eligibility:

    - Individuals of any age who have a psychiatric, autism spectrum, or developmental disorder, or other behavioral problems.

    - Family members of individuals with the above disorders. This group may include parents, grandparents, siblings, aunts/uncles, cousins, and children.

    Design:

    - Participants will be screened with a medical history and physical exam. They will have a psychiatric history with tests of thinking, judgment, and behavior. Blood and urine samples will be collected. Brain imaging scans will be performed to look at brain function. They may have a spinal tap to collect cerebrospinal fluid.

    - Relatives will have a medical history and physical exam. They will also have a psychiatric history with tests of thinking, judgment, and behavior. Blood and urine samples will be collected. Brain imaging scans will be performed to look at brain function.

    - A relative s exams may reveal a behavioral or other disorder. If so, he or she may re-enroll on the study as a person with the disorder.

  • Cognitive-Behavioral Therapy and Supportive Psychotherapy for Body Dysmorphic Disorder
    Study Type: Interventional
    Start Date: August 1, 2011
    Locations: Boston, Massachusetts; Providence, Rhode Island
    Eligibility: Ages 18 and Older, Does Not Accept Healthy Volunteers

    The purpose of this study is to learn more about two different types of psychotherapy to help individuals who have body dysmorphic disorder (BDD). BDD is a severe, often chronic, and common disorder consisting of distressing or impairing preoccupation with perceived defects in one's physical appearance. Individuals with BDD have very poor psychosocial functioning and high rates of hospitalization and suicidality. Because BDD differs in important ways from other disorders, psychotherapies for other disorders are not adequate for BDD. Despite BDD's severity, there is no adequately tested psychosocial treatment (psychotherapy) of any type for this disorder. This study will compare the effectiveness of Cognitive Behavioral Therapy and Supportive Psychotherapy as well as predictors of improvement.

  • Physiological Brain Atlas Development
    Study Type: Observational
    Start Date: August 1, 2006
    Location: Nashville, Tennessee
    Eligibility: Ages 1 Year–90, Does Not Accept Healthy Volunteers

    The NIH grant has funded the development of a physiological brain atlas registry that will allow us to significantly improve the data collectioin and use of physiological data into a normalized brain volume. This initially was used to improve DBS implants for Parkinson's Disease, Dystonia, Essential Tremor, and OCD, but now includes data acquired during all stereotactic brain procedures.