Obsessive-Compulsive Disorder (OCD)
Obsessive-compulsive disorder (OCD) is a common, chronic, and long-lasting disorder characterized by uncontrollable, reoccurring thoughts (obsessions) and/or behaviors (compulsions) that people feel the urge to repeat over and over. Symptoms can fluctuate over time, and people with OCD may try to help themselves by avoiding situations that trigger their obsessions. OCD is a common disorder that affects adults, adolescents, and children, and most people with the disorder are diagnosed by early adulthood. Learn more about obsessive-compulsive disorder (OCD).
Featured studies include only those currently recruiting participants. Studies with the most recent start date appear first.
Start Date: October 15, 2019
Location: New Haven, Connecticut
Eligibility: Ages 18–65, Accepts Healthy Volunteers
The proposed randomized, double-blind research study will use functional magnetic resonance neuroimaging using state-of-the-art HCP acquisition protocols and analytic pipelines, to identify predictors and correlates of response to an accepted first-line pharmacological treatment for obsessive-compulsive disorder.
Enhancing Treatment of Hoarding Disorder With Personalized In-Home Sorting and Decluttering PracticeStudy Type: Interventional
Start Date: September 30, 2016
Location: Stanford, California
Eligibility: Ages 18–70, Accepts Healthy Volunteers
The proposed study aims to investigate the efficacy of adding in-home decluttering practice to Buried in Treasures Workshop (BIT) facilitated group treatment for hoarding disorder.
Start Date: July 31, 2015
Location: New Haven, Connecticut
Eligibility: Ages 18–65, Does Not Accept Healthy Volunteers
The aim of this study is to train patients with obsessive-compulsive disorder to control a region of their brain that has been associated with their symptoms. Patients in the experimental group will be given direct feedback regarding activity in this brain area while they are undergoing functional magnetic resonance imaging (fMRI) scanning, and will try to learn to control activity in the region during these feedback sessions. A separate group of patients will be given a control form of feedback that we do not believe can have clinical benefits. Our primary hypothesis is that the neurofeedback training will reduce OCD symptoms more than the control feedback.
Start Date: December 27, 2012
Location: Bethesda, Maryland
Eligibility: Ages N/A–99, Does Not Accept Healthy Volunteers
- Many psychiatric, behavioral, and developmental disorders are genetic. This means that they tend to run in families. Some begin in childhood, while others do not appear until adulthood. Researchers want to look at people of all ages who have these disorders that started in childhood. They will also look at relatives of people with these disorders. This information will allow doctors to learn more about childhood behavioral problems and how they are inherited. It may also help doctors treat those disorders.
- To study the onset and treatment of childhood behavioral, psychiatric, and developmental disorders.
- Individuals of any age who have a psychiatric, autism spectrum, or developmental disorder, or other behavioral problems.
- Family members of individuals with the above disorders. This group may include parents, grandparents, siblings, aunts/uncles, cousins, and children.
- Participants will be screened with a medical history and physical exam. They will have a psychiatric history with tests of thinking, judgment, and behavior. Blood and urine samples will be collected. Brain imaging scans will be performed to look at brain function. They may have a spinal tap to collect cerebrospinal fluid.
- Relatives will have a medical history and physical exam. They will also have a psychiatric history with tests of thinking, judgment, and behavior. Blood and urine samples will be collected. Brain imaging scans will be performed to look at brain function.
- A relative s exams may reveal a behavioral or other disorder. If so, he or she may re-enroll on the study as a person with the disorder.
Start Date: August 31, 2006
Location: Nashville, Tennessee
Eligibility: Ages 6–90, Does Not Accept Healthy Volunteers
The NIH grant has funded the development of a physiological brain atlas registry that will allow us to significantly improve the data collectioin and use of physiological data into a normalized brain volume. This initially was used to improve DBS implants for Parkinson's Disease, Dystonia, Essential Tremor, and OCD, but now includes data acquired during all stereotactic brain procedures.