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Panic Disorder

Featured Studies

Featured studies include only those currently recruiting participants. Studies with the most recent start date appear first.

  • Dimensional Brain Behavior Predictors of CBT Outcomes in Pediatric Anxiety
    Study Type: Interventional
    Start Date: December 1, 2016
    Location: Ann Arbor, Michigan
    Eligibility: Ages 7–17, Accepts Healthy Volunteers

    Anxiety is among the most prevalent, costly and disabling illnesses and tends emerge early in childhood. Cognitive behavioral therapy (CBT) is the first-line treatment for early life anxiety, but as many as 40% of young patients who receive CBT fail to get better. The proposed study will examine brain changes marking positive response to CBT for anxiety and how these changes may differ in children compared adolescents. By helping us to understand how CBT works, this study will pave the way for new treatments to stop anxiety early.

  • Neural Basis of Meal Related Interoceptive Dysfunction in Anorexia Nervosa
    Study Type: Interventional
    Start Date: October 1, 2015
    Location: Tulsa, Oklahoma
    Eligibility: Ages 18–55, Accepts Healthy Volunteers

    This study aims to identify the brain regions responsible for encoding cardiorespiratory 'interoceptive' sensations and determine whether they are dysfunctional in individuals affected by eating disorders, anxiety, depression, or brain injury. By evaluating the same interoceptive sensations across different human illnesses, the investigators hope to provide convergent evidence resulting in identification of core underlying neural processes, and to discern relative contributions in each condition.

  • Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders
    Study Type: Observational
    Start Date: November 6, 2006
    Location: Bethesda, Maryland
    Eligibility: Ages 18–65, Accepts Healthy Volunteers

    This study is intended to help develop new MRI imaging techniques for studying mood and anxiety disorders. Researchers believe that depression and anxiety disorders may cause structural and functional changes in the brain. This study will optimize the way MRI scans are collected to look at brain structure and examine how the brain behaves while subjects perform particular tasks.

    Healthy normal subjects between 18 and 50 years of age who have never had a major psychiatric disorder and who have no first-degree relatives with mood disorders may be eligible for this study. Candidates are screened by phone with questions about their psychiatric and medical history, current emotional state and sleep pattern, and family history of psychiatric disorders. Candidates who pass the preliminary screening then undergo additional screening interviews and laboratory tests.

    Participants undergo magnetic resonance imaging (MRI) and neuropsychological testing, as follows:

    " MRI scans: Subjects are asked to participate in an MRI study on one of several scanners to measure blood flow in the brain, concentrations of certain chemicals in the brain, or magnetic properties of the brain. MRI uses a strong magnet and radio waves to obtain pictures of the brain. The subject lies still on a narrow bed with a metal coil close to the head. For this study, subjects may be asked to wear a special coil on the neck to help measure blood flow. They may be asked to watch a screen presenting images or to do a task in which they respond to pictures or sounds and may be asked to return for additional scans.

    " Neuropsychological testing: Subjects may undergo tests of cognitive performance. Often, people with mood disorders have subtle changes in performance on these tests that allow researchers to pinpoint where brain abnormalities occur. Before the tests can be used in patients, they must be validated by using healthy subjects. These tests are presented either orally, in written form, or on a computer.

  • Expectation of Unpleasant Events in Anxiety Disorders
    Study Type: Observational
    Start Date: February 20, 2003
    Location: Bethesda, Maryland
    Eligibility: Ages 18–50, Accepts Healthy Volunteers

    Fear and anxiety are normal responses to a threat. However, anxiety is considered abnormal when the response to the threat is excessive or inappropriate. This study will examine changes in the body and brain that occur during unpleasant learning experiences in healthy volunteers with high, moderate, and low levels of anxiety.

    A high degree of generalized anxiety is a component of many anxiety disorders and is regarded as a marker of vulnerability for these disorders. People with anxiety disorders and individuals with high degrees of anxiety have inappropriate expectations of unpleasant events. This study will investigate the development of expecting unpleasant events in healthy volunteers with varying degrees of anxiety using aversive conditioning models. A later phase of the study will enroll participants with anxiety disorders and compare their responses to those of healthy volunteers.

    Patients who meet criteria for an anxiety disorder, and healthy volunteers who have no history of psychiatric or major medical illness will be enrolled in this study. Volunteers will come to the NIH Clinical Center three times for outpatient testing....

  • Evaluation of the Genetics of Bipolar Disorder
    Study Type: Observational
    Start Date: August 4, 1980
    Location: Bethesda, Maryland
    Eligibility: Ages 18–85, Does Not Accept Healthy Volunteers

    This study looks to identify genes that may affect a person's chances of developing bipolar disorder (BP) and related conditions.