Skip to main content

Transforming the understanding
and treatment of mental illnesses.

Celebrating 75 Years! Learn More >>

Suicide Prevention

Learn more about Suicide Prevention.

Join A Study

For opportunities to participate in NIMH research on the NIH campus, visit the clinical research website. Travel and lodging assistance may be available.

Featured Studies

Featured studies include only those currently recruiting participants. Studies with the most recent start date appear first.


Suicide Prevention Integration Into Task-shifted Mental Health Interventions 

Study Type: Interventional
Start Date: May 13, 2024
Eligibility: Females, 18 Years and Older, Accepts Healthy Volunteers
Location(s): Islamabad Capital Territory, Islamabad, Pakistan

Investigators will conduct a pilot clinical trial to assess the feasibility and acceptability of implementing a Suicide Prevention Package (SuPP) within an existing task-shifted depression intervention in rural Pakistan. This pilot research lays the groundwork for a future project to scale a package for multi-level suicide prevention strategies that can be integrated into community based mental health programs, particularly targeting individuals living in low-resourced settings. As the model is designed to be easily adapted and integrated, investigators anticipate the findings will be valuable for all researchers looking to improve population health and mental health services in disadvantaged settings.


A Digitally Assisted Risk Reduction Platform for Youth at High Risk for Suicide 

Study Type: Interventional
Start Date: April 7, 2024
Eligibility: 13 Years to 18 Years, Does Not Accept Healthy Volunteers
Location(s): Columbia University, New York, New York, United States

Despite efforts to prevent suicide, US rates are climbing, and suicide is the second leading cause of death among youth. Digital tools, especially personal smartphones, are promising avenues to address these issues and can be used to provide a unique understanding of risk factors, including psychological distress, anhedonia and behavioral withdrawal, and sleep disturbance among high-risk individuals. This project aims to enhance the effectiveness of the delivery of preventative health care to youth at risk for suicide by developing a comprehensive digital platform that allows practitioners to integrate mobile sensing data and HIPAA-compliant client communication tools into their management of these young people.


Improving Screening and Follow Up for Suicidal Ideation and Behaviors Among Latinx Youth in Primary Care 

Study Type: Interventional
Start Date: March 26, 2024
Eligibility: 25 Years to 100 Years, Accepts Healthy Volunteers
Location(s): BMS at Yard 56, Baltimore, Maryland, United States

The objective of this proposal is to develop and pilot a systems-level strategy in pediatric primary care to enhance identification and management of suicidal ideation and behavior in Latinx youth, particularly those in immigrant families with parents who have limited English proficiency (LEP). The investigators will focus on the use of trained community health workers (CHWs) to increase clinic capacity and quality of suicide risk screening and early intervention, with a focus on safety planning, parent psychoeducation and care coordination.

Specific aims are 1: To develop site-specific implementation protocols for the integration of CHWs into SIB screening and safety planning for Latinx youth and the youths families; 2: To pilot the implementation of the program in a six-month open trial in four pediatric primary care practices representing a range of usual practice settings; and 3: To engage a stakeholder network to explore barriers and facilitators, including costs and billing strategies, to implementation of this approach across a broad range of pediatric primary care settings.

Parents/guardians of youth who have been referred to and agree to participate in the intervention by the child's primary care provider will participate in a 2-month program consisting of 6-8 phone sessions with a community health worker focusing on safety planning, information/education, program solving and self-care. Research participants will be asked to complete a survey via phone at the beginning of the program and another at the end of the program. The participants may also be asked to participate in an additional interview about the study.


Improving Care, Accelerating Recovery and Education 

Study Type: Interventional
Start Date: February 29, 2024
Eligibility: 12 Years to 17 Years, Does Not Accept Healthy Volunteers
Location(s): Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States

The goal of this clinical trial is to test the I-CARE program in children who are in a medical hospital awaiting inpatient mental health treatment. The main questions it aims to answer are:

Can the I-CARE program be used at the medical hospitals and do the patients and hospital staff like the program? Does the I-CARE program lower patients' emotional distress, thoughts about suicide or suicide attempts?

Patients will complete as many of the 7 I-CARE videos as possible during their stay at the medical hospital and fill out online surveys. There are workbook activities that go with each I-CARE video. A hospital staff member will help the patient do the videos and workbook activities.


Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior 

Study Type: Interventional
Start Date: February 28, 2024
Eligibility: 13 Years to 21 Years, Does Not Accept Healthy Volunteers
Location(s): University of Minnesota, Minneapolis, Minnesota, United States

The goal of this study is to understand why some people act more impulsively when feeling negative emotions, which is called negative urgency. The researchers hope to understand how negative urgency relates to the way networks of brain cells communicate with one another. The researchers will measure negative urgency and brain signals in adolescents aged 13-21 years with depression and suicidal thoughts and behaviors.

The main questions it aims to answer are:

Whether a type of brain signaling called cortical inhibition is related to negative urgency Whether depressed adolescents with suicidal behavior have more problems with cortical inhibition than depressed adolescents with suicidal thoughts only Whether the relationship between negative urgency and cortical inhibition changes over time

Adolescents who participate in the study will complete the following activities at the time they join the study, as well as 6 months and 12 months later:

Interviews with researchers and questionnaires to learn about their thoughts, emotions, and symptoms A questionnaire about impulsive behaviors and negative urgency Computerized games that measure brain functions An MRI scan of the brain Transcranial magnetic stimulation with electroencephalography (TMS-EEG), a way to measure how brain cells communicate (cortical inhibition) using a magnet placed outside of the head and recording brain signals


Efficacy, Effectiveness, and Implementation of Jaspr Health in Emergency Department- Part A 

Study Type: Interventional
Start Date: February 23, 2024
Eligibility: 18 Years and Older, Does Not Accept Healthy Volunteers
Location(s): UMass Memorial Health, Worcester, Massachusetts, United States

This Study will comprehensively evaluate a multi-component suicide prevention technology (Jaspr Health) that facilitates delivery of suicided-related evidence-based practices (EBPs) while replacing wasted waiting time with productive time in the Emergency Departments (EDs). The EBPs satisfy several key performance elements for systems adopting Zero Suicide.

A Complementary Randomized Controlled Trial and Real-World Study for Efficacy, Effectiveness, and Implementation Study Design (CREID) will be used


Examining Feasibility, Acceptability, and Sustainability of a Novel Personalized Smartphone Intervention for Suicide - Open Trial 

Study Type: Interventional
Start Date: December 4, 2023
Eligibility: 18 Years to 70 Years, Does Not Accept Healthy Volunteers
Location(s): Brown University, Providence, Rhode Island, United States; Butler Hospital, Providence, Rhode Island, United States

The primary aim of the present study is leverage existing infrastructure to develop novel technological features for a novel personalized smartphone intervention system, called the Mobile Application to Prevent Suicide (MAPS), and to establish feasibility, acceptability, safety, and estimate key parameters for secondary outcomes (i.e., suicidal ideation and behavior; re-hospitalization).


Digital Youth-Nominated Support Team (YST) Program 

Study Type: Interventional
Start Date: November 27, 2023
Eligibility: 13 Years to 17 Years, Does Not Accept Healthy Volunteers
Location(s): Michigan Medicine, Ann Arbor, Michigan, United States

The Electronic Youth-Nominated Support Team (eYST), is experimental. The purpose of this study is to get feedback from users about eYST. Another purpose of this study is to learn how well eYST helps youth.


Development and Testing of imHere4U: A Digital Suicide Prevention Intervention for Cyberbullied Adolescents 

Study Type: Interventional
Start Date: November 21, 2023
Eligibility: 12 Years to 17 Years, Does Not Accept Healthy Volunteers
Location(s): University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States

The objective of this study is to test the feasibility and preliminary efficacy of Flourish (formerly referred to as imHere4U), a digital suicide prevention intervention for cyberbullied adolescents.

The specific aims are to:

Aim #1: Conduct a randomized controlled trial (RCT) comparing Flourish+Questionnaires vs. Questionnaires Alone among cyberbullied youth at-risk for suicide ages 12-17 (N=80, >35% underserved youth).

H2a. Primary outcome: Feasibility will be evidenced by recruitment/retention rates > 80% and imHere4U engagement > 70%.

H2b. Secondary outcomes: Youth assigned to Flourish+Questionnaires will report improved problem-solving capacity, distress tolerance, and motivation and reduced distress and suicidal ideation than youth assigned to Questionnaires Alone over the 6-month follow-up period.

Exploratory Aim: Examine the feasibility of delivering feedback on online interactions from machine learning algorithms. All youth assigned to Flourish may optionally provide their social media data to receive feedback from machine learning algorithms. H3a. Feedback from algorithms will have high acceptability (identified via qualitative themes and >70% acceptance rates) and usability, defined by mean scores on Post-Study System and Usability Questionnaire (PSSUQ) > 6.


Risk and Resilience to Suicide Following Late-Life Spousal Bereavement 

Study Type: Interventional
Start Date: November 20, 2023
Eligibility: 65 Years and Older, Does Not Accept Healthy Volunteers
Location(s): University of Pittsburgh (UPMC), Pittsburgh, Pennsylvania, United States

The purpose of the RISE study is to examine how the 24-hour rhythm of sleep and social activity relate to mood and suicidal ideation among older adults that recently lost a spouse or life partner.


Swift Outpatient Alternatives for Rapid Stabilization 

Study Type: Interventional
Start Date: November 9, 2023
Eligibility: 13 Years to 21 Years, Does Not Accept Healthy Volunteers
Location(s): Seattle Children's, Seattle, Washington, United States

The goal of this clinical trial is to improve the effective outpatient management of acute youth suicide risk by optimizing intervention components to build an efficient, evidence-based intervention that is responsive to the needs of, and coordinated with, providers in primary care settings. The main questions are:

What is the strongest combination of SOARS components associated with reduction in youth suicidal thoughts and behavior (STB)? Do age and STB history moderate the impact of the effects of the SOARS intervention components? Do therapeutic alliance, youth and caregiver self-efficacy account for changes in youth STBs? What helps medical outpatient providers refer to SOARS and continue care after SOARS?


Navigating Mental Health Treatment for Black Youth 

Study Type: Interventional
Start Date: September 28, 2023
Eligibility: 10 Years to 18 Years, Accepts Healthy Volunteers
Location(s): The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States

This study looks to conduct a systematic adaptation of Suicidal Teens Accessing Treatment (STAT-ED) for Black youth presenting in the emergency department who have suicide risk. A randomized controlled trial of STAT-ED adapted for Black youth and their caregivers will examine whether patient navigation intervention can increase mental health treatment initiation and number of visits.


Real-time Intervention for Suicide Risk Reduction 

Study Type: Interventional
Start Date: September 25, 2023
Eligibility: 18 Years and Older, Does Not Accept Healthy Volunteers
Location(s): Brigham and Women's Faulkner Hospital, Boston, Massachusetts, United States

The aim of this study is to determine whether learning three skills for managing negative emotions and receiving reminders via smartphone to practice these skills reduces how often and how intensely one experiences emotional distress and suicidal thoughts.


Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality 

Study Type: Interventional
Start Date: September 18, 2023
Eligibility: 50 Years to 80 Years, Does Not Accept Healthy Volunteers
Location(s): Weill Cornell Medicine, New York, New York, United States

The investigators hypothesized that during the 9-week course of Engage & Connect treatment there will be an increase in brain functions of the Positive Valence System which in turn will lead to reduction in suicidality.


Supplementing Brief Psychotherapy With a Mobile App 

Study Type: Interventional
Start Date: September 14, 2023
Eligibility: 18 Years and Older, Does Not Accept Healthy Volunteers
Location(s): Rutgers University Behavioral Healthcare, Piscataway, New Jersey, United States

Suicide is among the leading causes of death worldwide, and the risk of suicide is highest in the period immediately following discharge from inpatient psychiatric care.1Importantly, despite the enormously elevated risk during this period, nearly 50% of patients do not attend scheduled therapy after discharge. Even among those who do attend therapy, however, the skills learned in treatment may be difficult to use during the highly distressing time leading up to and during a suicide crisis. Most traditional treatments are not designed to be effective during a suicide crisis. In order to reduce the risk of suicidal thoughts and behaviors in general and specifically during the post-discharge period, interventions are needed that: (1) are easily adhered to and (2) are accessible and effective during a suicide crisis. As such, the purpose of this research study is to test an innovative, new intervention in order to develop an effective and accessible intervention for those at high risk for suicide


Stepped Approach to Reducing Risk of Suicide in Primary Care 

Study Type: Interventional
Start Date: August 8, 2023
Eligibility: 12 Years to 17 Years, Does Not Accept Healthy Volunteers
Location(s): Hilliard Pediatrics, Hilliard, Ohio, United States; Eastglen Pediatrics, Columbus, Ohio, United States

Suicide is the second leading cause of death among young people aged 12-17 years in the United States, yet many youth at risk for suicide are not identified or go untreated. Stepped care approaches have been shown to be effective at reducing suicide risk in clinical settings, including primary care. The goal of this hybrid I stepped wedge effectiveness-implementation study is to test the effectiveness of a population-based quality improvement (QI) intervention, entitled STARRS-PC (Stepped Approach to Reducing Risk of Suicide in Primary Care) compared to treatment as usual (TAU), in reducing the risk of suicidal behavior among youth in the pediatric primary care setting. STARRS-PC implements a clinical pathway for youth at elevated risk for suicide in pediatric primary care clinics. Clinical pathways are tools used by health professionals to guide evidence-informed practice. The STARRS-PC pathway consists of three evidence-based suicide clinical care processes: risk detection, assessment and triage, and, if needed, follow-up transitional care.

STARRS-PC is guided by the Practical, Robust Implementation, and Sustainability Model (PRISM), which allows for the study of factors that influence effective implementation of the suicide prevention clinical pathway and is focused on scalability.

The main questions the study aims to answer are:

Will STARRS-PC be more effective than TAU at reducing the rate of suicide attempt at 12 months post-baseline (primary outcome)? Will STARRS-PC be more effective than TAU at reducing suicidal ideation and non-suicidal self-injury, and improving family satisfaction at 12 months post-baseline (secondary outcomes)? What are the barriers and facilitators of effective implementation and sustainability of STARRS-PC?


Practice Experiences for School Reintegration 

Study Type: Interventional
Start Date: August 1, 2023
Eligibility: Old, Does Not Accept Healthy Volunteers
Location(s): UNC Adolescent Psychiatry Inpatient Unit, Chapel Hill, North Carolina, United States

This study is developing and refining a novel Virtual Reality (VR) supplement for inpatient treatment: the Practice Experiences for School Reintegration (PrESR) program. The PrESR will provide immersive school experiences for inpatient adolescents (with suicidal-related admissions) to practice skills in real-world settings with the guidance of a trained clinician within the confines of a hospital. This pilot study follows a Multiphase Optimization Strategy (MOST) to conduct a pilot optimization trial of the PrESR to inform the feasibility of training clinicians, the ability to recruit adolescent inpatient participants, and management of experimental conditions. This study is not powered to test hypotheses; however, in addition to assessing feasibility and acceptability, this pilot trial will assess candidate intermediary and outcome measures.


Study 1: Social Engage Coaching R61 Phase 

Study Type: Interventional
Start Date: June 1, 2023
Eligibility: 60 Years and Older, Does Not Accept Healthy Volunteers
Location(s): University of Rochester, Rochester, New York, United States

The purpose of this study is to test whether an individual coaching program called Social Engage Coaching (or 'Engage Coaching' for short) helps adults age 60 and older feel more connected to other people in ways that matter to them. Procedures include participating in a Social Engage Coaching program, research assessments with surveys, and assessments completed on a cell phone. Engage Coaching involves individual sessions with a trained Engage Coach (up to 10 sessions) that are designed to help participants improve social relationships and well-being. All subjects will receive the scheduled baseline and follow-up interviews by the research team. These interviews will be conducted at study start, mid-way through the program at 8 weeks and after completing the program at 16 weeks. Interviews will be via Zoom/phone as well as surveys done online.


Suicide Prevention for Sexual and Gender Minority Youth (Randomized Controlled Trial) 

Study Type: Interventional
Start Date: April 10, 2023
Eligibility: 15 Years to 29 Years, Accepts Healthy Volunteers
Location(s): San Diego State University, San Diego, California, United States

The overarching goal of this study is to evaluate a newly-developed suicide prevention program for sexual and gender minority youth and emerging adults. After development of the intervention program, a randomized controlled trial will be conducted to test its preliminary efficacy in lowering the risk for suicide attempts.


Brief Suicide Intervention for Youth in Juvenile Detention Settings 

Study Type: Interventional
Start Date: April 7, 2023
Eligibility: 13 Years to 18 Years, Accepts Healthy Volunteers
Location(s): Wake Forest School of Medicine, Winston-Salem, North Carolina, United States; Duke University, Durham, North Carolina, United States

This is an intervention development study and therefore is not designed or powered to test hypotheses. Following initial development and refinement of intervention and protocol, an open trial will be conducted at one juvenile detention facility (n=20). Following further refinement, six juvenile detention sites will be randomized to first or second wave of intervention implementation. All youth at an implementation site in suicidal crises will receive the intervention. Data will only be collected from youth with prior assent/consent. Youth will be assessed at the time of the suicidal/self-harm crisis, and at 2 and 4 weeks after initial intervention, and at a two-month follow-up assessment. We will preliminarily examine feasibility of the intervention and associated patterns of suicidal thoughts and behavior and non-suicidal self-injury, linkage to care following release, and presumed mechanisms of change such as hopelessness, self-efficacy to remain safe, urgency to act on suicidal thoughts, and acceptance.


Therapeutic Evaluative Conditioning to Reduce Adolescents' Self-injurious Thoughts and Behaviors During and After Psychiatric Inpatient Hospitalization 

Study Type: Interventional
Start Date: March 31, 2023
Eligibility: 12 Years to 19 Years, Does Not Accept Healthy Volunteers
Location(s): Franciscan Hospital For Children, Inc., Brighton, Massachusetts, United States

Suicide is the 2nd leading cause of death among adolescents, with the highest risk period for suicide being the month following psychiatric inpatient hospitalization. The investigators propose testing a brief, scalable intervention using evaluative conditioning aimed at reducing suicidal thoughts and behaviors among adolescents during and after inpatient hospitalization. Scalable interventions, such as the one proposed that reduce suicide risk during this markedly high-risk period, could result in large-scale decreases in suicide death.


Clinical Trial for Integrated Care to Help At Risk Teen (iCHART) Intervention 

Study Type: Interventional
Start Date: January 26, 2023
Eligibility: 12 Years to 18 Years, Does Not Accept Healthy Volunteers
Location(s): Children's Community Pediatrics (CCP- Waterdam) of Children's Hospital of Pittsburgh UPMC, McMurray, Pennsylvania, United States; UPMC Center for Adolescent and Young Adult Health, Pittsburgh, Pennsylvania, United States

This protocol will test the effectiveness of an intervention, iCHART (integrated Care to Help At-Risk Teens) and facilitate recruitment for other studies in the larger ETUDES Center grant, which are focused on treatment development for target risk factors for suicidal behavior, specifically, sleep, anhedonia, and stress related to cybervictimization. This study will recruit 900 adolescents which will be enrolled in a randomized controlled trial to test iCHART and will be randomized to iCHART or treatment as usual (TAU). Based on previous work, the investigators hypothesize that iCHART, compared to TAU, will decrease suicidal-related events by 50%, and the effects will be mediated by increases in referrals, treatment engagement, and safety planning. The investigators will use implementation science methods to assess contextual factors (i.e., barriers and facilitators) and implementation outcomes specifically, acceptability, feasibility, appropriateness, and cost for our predictive algorithm and iCHART to inform future implementation efforts and promote health equity.


Adaptive Intervention for Adolescents Following Inpatient Psychiatric Care 

Study Type: Interventional
Start Date: November 7, 2022
Eligibility: 13 Years to 17 Years, Does Not Accept Healthy Volunteers
Location(s): University of Michigan's (Child and Adolescent Psychiatric Inpatient Program), Ann Arbor, Michigan, United States

This study is being completed to examine different combinations of technology-augmented strategies to identify an effective Adaptive intervention (AI) addressing post-discharge suicide risk with high implementation potential.


Comprehensive Adaptive Multisite Prevention of University Student Suicide 

Study Type: Interventional
Start Date: October 25, 2022
Eligibility: 18 Years to 25 Years, Does Not Accept Healthy Volunteers
Location(s): University of Nevada - Reno, Reno, Nevada, United States; University of Oregon, Eugene, Oregon, United States; Duke University, Durham, North Carolina, United States; Rutgers University, New Brunswick, New Jersey, United States

Suicide is the 2nd leading cause of death among college students and suicidal ideation and suicide-related behaviors are a frequent presenting problem at college counseling centers (CCCs), which are overburdened. Studies show that some students respond rapidly to treatment, whereas others require considerably more resources. Evidence-based adaptive treatment strategies (ATSs) are needed to address this heterogeneity in responsivity and complexity. ATSs individualize treatment via decision rules specifying how the type and intensity of an intervention can be sequenced based on risk factors, response, or compliance.

The purpose of this multisite study is to investigate the effectiveness of four adaptive treatment strategies (ATSs) to treat college students who report suicidal ideation when first seeking services at their college counseling center

This multisite study will enroll moderately to severely suicidal college students in the "emerging adulthood" phase (ages 18-25) seeking services at CCCs. This Sequential Multi-Assignment Randomized Trial (SMART) will have two stages of intervention. In Stage 1, 700 participants from four CCCs will be randomized to 4-8 weeks of: 1) a suicide-focused treatment - Collaborative Assessment and Management of Suicidality (CAMS) or 2) Treatment as Usual (TAU). Sufficient responders to either intervention will discontinue services/be stepped down. Non-responders will be re-randomized to one of two Stage 2 higher intensity/dosage intervention options for an additional 4-16 weeks: 1) CAMS (either continued or administered for the first time) or 2) Comprehensive Dialectical Behavior Therapy (DBT), which includes individual therapy, skills group, and phone/text coaching for the clients and peer consultation for the counselors.


Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents 

Study Type: Interventional
Start Date: October 3, 2022
Eligibility: 13 Years to 18 Years, Does Not Accept Healthy Volunteers
Location(s): UT Southwestern Medical Center, Dallas, Texas, United States

This project aims to examine the efficacy of ketamine, a rapidly acting medication shown to decrease suicidality in adults in as short as hours or days, as opposed to weeks.

The study design is a double-blind, randomized, active-control trial of adolescents (ages 13-18 years) with recent suicidal behaviors (suicide attempt or increased suicidal ideation). All participants must be receiving standard of care treatment which may range broadly from both outpatient and inpatient programs which include clinically indicated psychosocial and/or psychopharmacological treatments. Ketamine/midazolam treatment will occur twice weekly during the first two weeks of the study, followed by weekly assessments through week 12.


Cognitive Processing Therapy (CPT) for Posttraumatic Stress Disorder and Borderline Personality Disorder (PTSD-BPD) 

Study Type: Interventional
Start Date: October 1, 2022
Eligibility: 18 Years to 65 Years, Does Not Accept Healthy Volunteers
Location(s): Palo Alto University, Palo Alto, California, United States

Posttraumatic Stress Disorder (PTSD) with co-occurring Borderline Personality Disorder (BPD) (i.e., PTSD-BPD) is common (as high as 58%), debilitating, costly, and limited treatment options available for this population. PTSD-BPD is associated with even greater functional impairment and higher healthcare burden than either disorder alone. There are surprisingly few treatments available for this clinical profile, despite its association with major negative health outcomes, cost, and morbidity. There is a pressing need to innovate treatments that can effectively and efficiently treat PTSD-BPD. The existing treatments used for PTSD-BPD are lengthy, laborious, resource-intensive, and require complete cessation of suicidal behaviors prior to treatment. Furthermore, no integrated treatment has been innovated to deliver the active ingredients to efficiently affect the mechanisms underpinning this comorbidity. The investigators propose to examine an adapted version of a first-line PTSD intervention, Cognitive Processing Therapy, augmented with a Suicide Risk Management, i.e., (CPT+SRM) as a brief (12 sessions) and more parsimonious treatment alternative that strategically targets shared mechanisms underpinning PTSD and BPD. The purpose of this pilot study is to 1) collect initial feasibility, acceptability, and safety data on this adapted treatment, 2) conduct a pilot randomized clinical trial evaluating the efficacy of CPT+SRM versus Treatment as Usual (TAU) + SRM, and 3) evaluate two targets (i.e, improvements in emotional intensity and cognitive dysfunction) as mechanisms leading to change in our primary outcomes. Both treatment conditions will be administered via telehealth.

Potential benefits include reduction in participants' PTSD, BPD and other mental health symptoms. Additionally, this work could benefit the community by improving the treatment repertoire for PTSD-BPD. Potential risks include emotional distress, suicidality, and/or self-harm. Participants may experience discomfort and/or distress while discussing participants trauma(s) and mental health. These risks will be mitigated using a suicide risk management protocol which therapists in the assessment of risk and protective factors of suicide, followed by documentation for the decision-making around the management of risk.


Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents 

Study Type: Interventional
Start Date: October 1, 2022
Eligibility: 10 Years to 24 Years, Accepts Healthy Volunteers
Location(s): University of Alabama at Birmingham, Birmingham, Alabama, United States; UAB Huntsville Regional Medical Campus, Huntsville, Alabama, United States

This study is dedicated to help identify biomarkers for depression and suicide. The purpose of the study is to better understand these links to improve medical and psychiatric care in the future. This research is also to test the effects of standard treatment of depression on improvement in depressive and suicidal behavior and on biomarkers (e.g. miRNA) for these disorders.


Cognitive Behavioral Suicide Prevention for Psychosis: Aim 2 

Study Type: Interventional
Start Date: September 1, 2022
Eligibility: 18 Years to 65 Years, Does Not Accept Healthy Volunteers
Location(s): University of Michigan, Ann Arbor, Michigan, United States

Investigators will evaluate the feasibility and preliminary effectiveness of modified Cognitive Behavioral Suicide Prevention for psychosis (CBSPp) in comparison to services-as-usual (SAU) in a randomized controlled trial. Investigators will recruit adult clients receiving services at a community mental health (CMH) setting who have a schizophrenia spectrum disorder and recent suicidal thoughts or behaviors within 3 months of screening (n=60). Client participants will be screened, enrolled and randomized to the CBSPp or SAU group. A 4-wave design will include quantitative assessments at baseline (T1), 1-month after baseline (T2), 3-months after baseline (T3), and 5-months after baseline (T4) with in-depth qualitative interviews at T3 for a random sample of adults in the CBSPp group (n=10). Providers (n=12) will be trained to deliver CBSPp and be assessed from T1-T3 to evaluate the implementation process, including in-depth qualitative interviews at T3.


Ketamine Treatment of Youth Suicide Attempters 

Study Type: Interventional
Start Date: June 27, 2022
Eligibility: 14 Years to 30 Years, Does Not Accept Healthy Volunteers
Location(s): Massachusetts General Hospital, Boston, Massachusetts, United States; The Cleveland Clinic, Cleveland, Ohio, United States

Ketamine, an NMDA antagonist, has been shown to have rapid anti- suicidal effects. However, its safety and efficacy and special populations has not been investigated and documented. Several reports in adults suggest rapid decrease of suicidal ideation. In the last decade there is an alarming increase of the number of suicide attempts in patients ages 14-30. Suicide is the second leading cause of death in this population. Patients with previous history of suicide attempt, are even in a higher risk category. The present study focus in this high risk group of suicide attempters. This will be a randomized controlled trial enrolling 140 youth between the ages 14-30 after a suicide attempt; patients will be randomized to receive Ketamine 0.5 mg/kg over 40 minutes or normal saline. Patients will receive all Ketamine or placebo infusions while admitted in the Inpatient Psychiatry Service. Patients will receive up to 6 ketamine or placebo infusions until, for 3 consecutive sessions, they have a clinician rated Scale for Suicidal Ideation (SSI) score of<4, and >50% decrease from baseline, and clinical assessment of patient not being suicidal, or they have been discharged from the inpatient unit. Patients will participate in weekly sessions of Collaborative Assessment for the management of Suicidality (CAMS), from the first week of the study while admitted to the hospital and will continue it on a weekly basis post-discharge until the patient has three consecutive outpatient CAMS sessions with an overall risk < 2 (# 6 on the SSF Core Assessment) along with a positive response regarding their thoughts/feelings and clinician indicating behavioral stability (suicidal behavior).


Culture and Well-Being for Latinos 

Study Type: Interventional
Start Date: June 1, 2022
Eligibility: 18 Years and Older, Does Not Accept Healthy Volunteers
Location(s): University of Rochester Medical Center, Rochester, New York, United States

The proposed K23 study is an intervention study using an experimental therapeutics approach. This pilot RCT asks: "Does SOCIAL-ENGAGE increase cultural-social engagement and decrease suicide risk among Spanish-speaking adults?" We will first optimize a behavioral intervention - SOCIAL ENGAGE (S-ENGAGE) - for target engagement using human-centered design approaches with Spanish-speaking adults at risk for suicide (n=5) and then conduct a pilot RCT (n=60) to test target engagement (cultural-social engagement) and clinical impact (suicide risk) of S-ENGAGE with this population. The ultimate goal is for S-ENGAGE to be offered as a suicide prevention program for Hispanics at risk for suicide.


Mental Health in Primary Care 

Study Type: Interventional
Start Date: April 26, 2022
Eligibility: 12 Years to 16 Years, Accepts Healthy Volunteers
Location(s): Borinquean Medical Centers, Miami, Florida, United States; UM UHealth Pediatrics at the Professional Arts Center, Miami, Florida, United States; UM Pediatric Mobile Clinic, Miami, Florida, United States; Banyan Health Systems, Miami, Florida, United States; Pediatric Mobile Clinic, Miami, Florida, United States; Mailman for Child Devlopment, Miami, Florida, United States; Care Resource, Miami, Florida, United States; Prime Care Health, Miami, Florida, United States; Broward Community Health, Miami, Florida, United States; Jessie Trice Community Health Center, Miami, Florida, United States; Pediatric Consultants of Kendall, P.A., Miami, Florida, United States; UHealth Pediatrics at Kendall, Miami, Florida, United States; South Florida Pediatric Partners, Miami, Florida, United States; Nicklaus Children Hospital, Miami, Florida, United States; Belkys Bravo Clinic, Miami, Florida, United States

The goal of this study is to evaluate in an effectiveness-implementation type I hybrid trial, an enhanced version of eHealth Familias Unidas for reducing depressive, anxious symptoms and suicide behavior in Hispanic youth. The study will use a randomized rollout design with 18 pediatric primary care clinics in the South Florida area.


WellPATH-PREVENT: A Mobile Intervention for Middle-Aged and Older Adults Hospitalized for Suicidal Ideation or Attempt 

Study Type: Interventional
Start Date: April 22, 2022
Eligibility: 50 Years to 90 Years, Does Not Accept Healthy Volunteers
Location(s): Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medicine, White Plains, New York, United States

The goal of this project is to test whether WellPATH-PREVENT (a novel, mobile psychosocial intervention) improves a specific aspect of emotion regulation, i.e., cognitive reappraisal ability, and reduces suicide risk in middle-aged and older adults (50-90 years old) who have been discharged after a suicide-related hospitalization (i.e. for suicidal ideation or suicide attempt).


Sequential Bilateral Accelerated Theta Burst Stimulation in Adolescents With Suicidal Ideation 

Study Type: Interventional
Start Date: April 4, 2022
Eligibility: 12 Years to 18 Years, Does Not Accept Healthy Volunteers
Location(s): Mayo Clinic in Rochester, Rochester, Minnesota, United States

The purpose of this study is to gather information regarding the use of a new type of transcranial magnetic stimulation (TMS) called theta burst stimulation (TBS) for suicidal ideation in adolescents with Major Depressive Disorder (MDD). The investigators hope to learn if this TMS treatment improves suicidal ideation over 10 days and clinical outcomes over 1 year of follow-up.


Preventing Suicide in African American Adolescents 

Study Type: Interventional
Start Date: February 1, 2022
Eligibility: 12 Years and Older, Accepts Healthy Volunteers
Location(s): Dunbar Vocational Career Academy, Chicago, Illinois, United States; Orr Academy High School, Chicago, Illinois, United States; Richard T. Crane High School, Chicago, Illinois, United States; Wendell Phillips Academy High School, Chicago, Illinois, United States

The overarching aim of the Success Over Stress Prevention Project is to reduce African American youth suicide. This study examines the impact of a 15-session, group-delivered, culturally-grounded, cognitive-behavioral intervention (i.e., PI Robinson's Adapted-Coping with Stress Course [A-CWS]), on the outcomes of interest, when it is delivered by social workers who are indigenous to the school system. The main objectives of this project are to (a) determine whether the intervention is effective when facilitated by social workers who are indigenous to the school system and (b) enhance resilience, increase adaptive coping strategies, and reduce both intrapersonal and interpersonal violence among youth receiving the prevention intervention. It is expected that increases in adaptive coping will lead to an increased ability for youth to manage stressors, thereby decreasing the incidence of suicide and violence among the youth. In addition, it is expected that evidence of the intervention's effectiveness, when facilitated by social workers who are indigenous to the school system, will lead to greater dissemination and sustainability of the intervention, thus, providing access to effective intervention resources to greater numbers of African American youth.


Reducing Adolescent Suicide Risk: Safety, Efficacy, and Connectome Phenotypes of Intravenous Ketamine 

Study Type: Interventional
Start Date: January 21, 2022
Eligibility: 13 Years to 17 Years, Does Not Accept Healthy Volunteers
Location(s): Yale New Haven Hospital, New Haven, Connecticut, United States

The purpose of this study is to determine if intravenous ketamine reduces suicidal thinking compared to an active placebo (midazolam) in adolescents who have treatment resistant depression and a recent history of a suicide event (defined as a suicide attempt, emergency room evaluation for suicidal thinking, or a transition to inpatient care for suicidality in the past 120 days).

The primary objective of this study is to determine whether ketamine reduces suicidal ideation (as measured via the C-SSRS, recent ideation scale) relative to an active control, midazolam, 48-hours after first administration in adolescents with TRD at high suicide risk.


Long-term Observation of Participants With Mood Disorders 

Study Type: Observational
Start Date: August 17, 2021
Eligibility: 18 Years and Older, Accepts Healthy Volunteers
Location(s): National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Background:

More than 12,000 people have taken part in research at the Experimental Therapeutics & Pathophysiology Branch at the National Institute of Mental Health Intramural Program. This has led to advances in the treatment of depression, bipolar disorder, and suicide risk. Researchers want to follow up with this group to see if they continue to have mental health symptoms and receive psychiatric treatments.

Objective:

To learn the long-term impact of depression, bipolar disorder, and suicide risk.

Eligibility:

Adults ages 18 and older who signed consent for Protocol 01-M-0254 over a year ago.

Design:

This study has 2 phases: an online phase and a telephone phase. It has no in-person or face-to-face contact.

In Phase 1, participants will fill out online surveys. They will access the surveys through the study website. The questions will focus on their current thoughts and feelings. The surveys will also ask about their current treatments for their mental health symptoms. At the end of the surveys, they will be asked if they would like to take part in Phase 2. If so, they will mark yes. Phase 2 includes a phone interview. They will be contacted by email to schedule the interview.

In Phase 2, participants will be asked more in-depth questions about how they are feeling. They will also be asked which psychiatric medicines and treatments they have used since they left NIH.

In both phases, participants can skip any questions they do not want to answer.

The online surveys will take 30 minutes to complete. The phone interview will last 1-4 hours.

The information that participants give in this study may be linked to their other NIH research records.


Ask Suicide-Screening Questions (ASQ) for Youth With Autism Spectrum and Neurodevelopmental Disorders 

Study Type: Observational
Start Date: July 15, 2021
Eligibility: 8 Years to 17 Years, Does Not Accept Healthy Volunteers
Location(s): Kennedy Krieger Institute/Johns Hopkins University, Baltimore, Maryland, United States; National Institutes of Health Clinical Center, Bethesda, Maryland, United States; Nationwide Children's Hospital/ Ohio State University, Columbus, Ohio, United States

Background:

Suicide is the second leading cause of death for young people ages 10-24 years. There is no gold standard for evaluating suicidal thoughts and behaviors in young people with autism spectrum disorder (ASD) or other neurodevelopmental disorders (NDD). Also, youth with ASD/NDD are often excluded from many research studies. Because of this, researchers need more data. They want to make sure they are asking the best questions for young people in clinics such as the National Institute of Mental Health (NIMH) clinic. They want to make sure they have the best data to determine if a person is at risk for hurting or killing himself or herself.

Objective:

To develop and assess the efficacy of a suicide screening tool for people with ASD/NDD.

Eligibility:

Youth ages 8 to 17 who are engaged in assessment or treatment at the NIMH for ASD or other NDD

Design:

Participants will fill out 4 questionnaires during a 1-hour meeting with study staff. They will answer questions about how they have been feeling. They will be asked if they think about or plan to hurt or kill themselves. They will also be asked if they have ever thought about it or planned it in the past. Other questions will assess their understanding of death. Participants can take a break if needed.

Parents of the participants will be asked similar questions.

Parents will be informed if their child has current thoughts of suicide.

About 1 week after the initial assessment, parents will be contacted to fill out a follow-up questionnaire. It will take about 10 minutes to complete.


Telehealth to Improve Prevention of Suicide (TIPS) 

Study Type: Interventional
Start Date: July 12, 2021
Eligibility: 18 Years and Older, Does Not Accept Healthy Volunteers
Location(s): UMass Chan Medical School, Worcester, Massachusetts, United States

The study will rigorously evaluate whether synchronous, within-visit telemental health evaluation and intervention services can successfully overcome poor access to behavioral health and substandard suicide-related care in emergency departments (EDs), including evaluating the impact on system metrics, a primary goal of RFA-MH-20-226. Notably, the study will surpass this primary requirement, because it will extend understanding of the relative added value of the ED-SAFE post-visit telephone intervention and will create knowledge about key factors related to implementation and sustainment.


Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention 

Study Type: Interventional
Start Date: March 5, 2021
Eligibility: 18 Years to 65 Years, Does Not Accept Healthy Volunteers
Location(s): UAB Medicine | Heersink School of Medicine, Birmingham, Alabama, United States; Yale University, New Haven, Connecticut, United States; Emory University, Atlanta, Georgia, United States

This is a rater-blinded, randomized controlled trial. All patients will receive esketamine for treatment of Major Depression with Suicidal Ideation (MDSI). Subjects will be randomized (1:1) to receive CBT (computer-assisted) or TAU alone following esketamine.


MicroRNA Correlates of Childhood Maltreatment and Suicidality 

Study Type: Observational
Start Date: February 26, 2021
Eligibility: 18 Years to 60 Years, Accepts Healthy Volunteers
Location(s): UAB Huntsville Regional Medical Campus, Huntsville, Alabama, United States; University of Alabama at Birmingham, Birmingham, Alabama, United States

This is a research study to find out if childhood trauma and stress are associated with depression or suicidal risk. The study will assess the effects of both short-term and long-term stress on biomarker (e.g. miRNA [MiRNA]) levels. miRNAs are a type of RNA (genetic material that is translated into protein) that are found in throughout the body and blood. They are called microRNA because their size is much smaller than typical RNA molecules. miRNAs are highly responsive to environment. This responsiveness is reflected in their expression in individuals who are affected by environment such as stress. The investigators are gathering genetic material, including DNA and RNA, from each participant. The RNA will be taken from the small vesicles and cells in the participant's blood and analyzed. The vesicles are small objects that occur normally in the blood and that contain RNA. This information may help us to understand the cause of mental illness and to improve medical and psychiatric care in the future. There will be 450 participants enrolled in this study.


Suicide in Urban Natives: Detection and Networks to Combat Events 

Study Type: Interventional
Start Date: March 15, 2020
Eligibility: 18 Years to 34 Years, Does Not Accept Healthy Volunteers
Location(s): First Nations Community HealthSource, Albuquerque, New Mexico, United States

This study compares the effectiveness of a program to detect and manage suicide risk among American-Indian and Alaska Native (AI/AN) youth. Half of the participants will receive caring text messages to reduce suicidal thoughts, attempts, and hospitalizations and to increase engagement, social connectedness, and resilience in at-risk youth. The other half will receive usual care that does not include the caring text messages.


Wakȟáŋyeža (Little Holy One) 

Study Type: Interventional
Start Date: November 18, 2019
Eligibility: 18 Years and Older, Accepts Healthy Volunteers
Location(s): Fort Peck Tribal Head Start, Poplar, Montana, United States

The overall goal of this study is to develop, adapt and evaluate an intergenerational prevention intervention, named "Wakȟáŋyeža (Little Holy One)," with Native American caregivers on a Northern Plains reservation and the caregivers' 2-to-5-year-old children. The intervention aims to: 1) reduce symptoms of historical trauma and everyday stress among parents/caregivers, 2) improve parenting, and 3) improve children's emotional and behavioral developmental outcomes to reduce future risk for suicide and substance use.


A Longitudinal Study of Inflammatory Pathways in Depression 

Study Type: Observational
Start Date: October 1, 2019
Eligibility: 18 Years and Older, Does Not Accept Healthy Volunteers
Location(s): Pine Rest Christian Mental Health Services, Grand Rapids, Michigan, United States

Suicide accounts for at least 1 million deaths globally each year. This is likely a significant underestimate, because suicide is under-reported in many countries. In the US, over 42,000 people die from suicide annually. Despite increased focus on identification and treatment, the rate of suicide has increased steadily over the past 15 years.

Our project aims both to improve our understanding of factors that increase the risk for suicide by comparing blood biomarkers associated with inflammation in patients with depression without suicidal behavior and patients with depression and suicidal behavior. The 160 individuals in this study will be followed with psychiatric assessments and blood samples at repeated time points over one year.


Promoting Community Conversations About Research to End Native Youth Suicide in Rural Alaska 

Study Type: Interventional
Start Date: September 12, 2019
Eligibility: 15 Years and Older, Accepts Healthy Volunteers
Location(s): University of Michigan, Ann Arbor, Michigan, United States

This intervention study measures the outcomes of the PC CARES (Promoting Community Conversations about Research to End Suicide) project implemented in remote rural Alaskan villages. Researchers worked with local service providers and other partners to recruit facilitators who were trained to implement the 5-session PC CARES curriculum. The study will compare pre-post data from intervention participants to non-participants, and will analyze social networks related to suicide prevention behavior in each village.


Wearable Suicidal Early Warning System for Adolescents 

Study Type: Observational
Start Date: September 18, 2017
Eligibility: 13 Years to 19 Years
Location(s): OHSU, Portland, Oregon, United States

This study is prospectively enrolling a cohort of adolescent patients who present to the Emergency Department and an inpatient psychiatric adolescent unit with acute suicidality.


A Novel Cognitive Reappraisal Intervention for Suicide Prevention 

Study Type: Interventional
Start Date: March 28, 2017
Eligibility: 50 Years to 90 Years, Does Not Accept Healthy Volunteers
Location(s): Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medicine, White Plains, New York, United States

The goal of this trial is to refine and test a novel emotion-regulation based psychosocial intervention designed to reduce suicide risk in middle-aged and older adults (50-90 years old) who have been discharged after a suicide-related hospitalization (i.e. for suicidal ideation or suicide attempt).


Neurobiology of Suicide 

Study Type: Interventional
Start Date: December 1, 2015
Eligibility: 18 Years to 70 Years, Accepts Healthy Volunteers
Location(s): National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Background:

There are no good treatments for people considering suicide. Researchers want to study suicide with questions, blood tests, brain imaging, and sleep studies. They hope to better understand suicide, so they can help suicidal people.

Objective:

To understand what happens in the brain when someone has thought about or attempted suicide.

Eligibility:

Group 1: Adults ages 18 70 who have thought about or attempted suicide recently

Group 2: Adults ages 18 70 who have thought about or attempted suicide in the past

Group 3: Adults ages 18 70 who have depression or anxiety, but have never thought about suicide

Group 4: Healthy volunteers the same ages.

Design:

Participants will be screened in another protocol. Adults who have recently thought about or attempted suicide must be referred by a doctor. They may do up to 3 phases of this study. Groups 2, 3 and 4 will do only Phase 1 and will not get ketamine.

Phase 1: 1 week in hospital. Participants will have:

Physical exam.

Questions about thoughts and feelings.

Thinking and memory tests and simple tasks.

Blood and urine tests.

Two MRI scans. Participants will lie on a table that slides into a metal cylinder that takes pictures. They will have a coil over their head and earplugs and do a computer task.

Sleep test. Disks and bands will be placed on the body to monitor it during sleep.

Magnetic detectors on their head while they perform tasks.

A wrist monitor for activity and sleep.

Lumbar puncture (optional). A needle will collect fluid from the back.

Shock experiments (optional). Participants will observe pictures and sounds and feel a small shock on the hand.

Phase 2: 4 days in hospital. A thin plastic tube will be placed in each arm, one for blood draws, the other to get the drug ketamine once. Participants will repeat most of the Phase 1 tests.

Phase 3: up to 4 more ketamine doses over 2 weeks.

Participants will have follow-up calls or visits at 6 months and then maybe yearly for 5 years.

...


Effectiveness of Empowerment Group Sessions for Treating Suicidal African American Women in Abusive Relationships 

Study Type: Interventional
Start Date: March 31, 2008
Eligibility: Females, 18 Years to 64 Years, Does Not Accept Healthy Volunteers
Location(s): Grady Hospital, Atlanta, Georgia, United States

This study will evaluate the effectiveness of culturally competent psychoeducational empowerment sessions in treating suicidal African-American women who are in abusive relationships.