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NIMH RDoC Publications

Browse publications about the Research Domain Criteria (RDoC), an NIMH initiative. RDoC is a research framework designed for studying the full range of human behavior from normal to abnormal based on biology, behavior, and context.


Clark LA, Cuthbert B, Lewis-Fernández R, Narrow WE, Reed GM. Three Approaches to Understanding and Classifying Mental Disorder: ICD-11, DSM-5, and the National Institute of Mental Health’s Research Domain Criteria (RDoC). Psychological Science in the Public Interest. 2017 Sep;18(2):72-145. PMID: 29211974

Garvey MA, Cuthbert BN. Developing a Motor Systems Domain for the NIMH RDoC Program. Schizophr Bull. 2017 Sep 1;43(5):935-936. doi: 10.1093/schbul/sbx095. PMID: 28911051

Vaidyanathan U, Pacheco J. Research Domain Criteria Constructs: Integrative reviews and empirical perspectives. J Affect Disord. 2017 Jul;216:1-2. doi: 10.1016/j.jad.2017.05.028. PMID: 28610708


Morris SE, Vaidyanathan U, Cuthbert BN. Changing the diagnostic concept of schizophrenia: the NIMH research domain criteria initiative. In The Neuropsychopathology of Schizophrenia 2016 (pp. 225-252). Springer International Publishing. PMID: 27627829

National Advisory Mental Health Council Workgroup on Tasks and Measures for Research Domain Criteria (2016). Behavioral Assessment Methods for RDoC Constructs. Bethesda, MD.

Sanislow CA. Connecting psychopathology meta-structure and mechanisms. J Abnorm Psychol. 2016 Nov;125(8):1158-1165. PMID: 27819475

Sanislow CA. Updating the Research Domain Criteria. World Psychiatry. 2016 Oct;15(3):222-223. doi: 10.1002/wps.20374. PMID: 27717261

Cuthbert BN. The NIMH Research Domain Criteria Project: Research Domain Criteria and global mental health. In M. State, BL. Miller, & T. Lehner (Eds). Genomics, Circuits, and Pathways in Clinical Neuropsychiatry. Cambridge, MA: Academic Press; 2016 Jun 7. (pp. 397 – 410).

Kozak MJ, Cuthbert BN. The NIMH Research Domain Criteria Initiative: Background, issues, and pragmatics. Psychophysiology. 2016 Mar;53(3):286-97. doi:10.1111/psyp.12518. PMID: 26877115

Garvey M, Avenevoli S, Anderson K. The National Institute of Mental Health Research Domain Criteria and Clinical Research in Child and Adolescent Psychiatry. J Am Acad Child Adolesc Psychiatry. 2016 Feb;55(2):93-8. doi: 10.1016/j.jaac.2015.11.002. PMID: 26802775

Goldstein AB, Morris SE. Reconceptualizing Prevention: Commentary on “Conducting Psychopathology Prevention Research in the RDoC Era”. Clinical Psychology: Science and Practice. Epub: 2016 Feb 16. DOI: 10.1111/cpsp.12143


Morris SE, Vaidyanathan U, Cuthbert BN. Psychophysiological science and the research domain criteria: A commentary. Int J Psychophysiol. 2015 Nov;98(2 Pt 2):378-80. doi: 10.1016/j.ijpsycho.2015.11.002. PMID: 26546860

Vaidyanathan U, Vrieze SI, Iacono, WG. The power of theory, research design, and transdisciplinary integration in moving psychopathology forward. Psychol Inq. 2015; 26(3): 209-230. doi:10.1080/1047840X.2015.1015367

Cuthbert BN. Research Domain Criteria: Toward future psychiatric nosologies. Dialogues Clin Neurosci. 2015 Mar;17(1):89-97. PMID: 25987867

Sanislow CA, Quinn KJ, Sypher I. NIMH Research Domain Criteria (RDoC) (2015). In (R. L. Cautin & S. O. Lilienfeld, Eds.) The Encyclopedia of Clinical Psychology. Hoboken, NJ: Wiley-Blackwell. 2015.


Cuthbert BN. Translating intermediate phenotypes to psychopathology: the NIMH Research Domain Criteria. Psychophysiology. 2014 Dec;51(12):1205-6. doi: 10.1111/psyp.12342. PMID: 25387702 

Ford JM, Morris SE, Hoffman RE, Sommer I, Waters F, McCarthy-Jones S, Thoma RJ, Turner JA, Keedy SK, Badcock JC, Cuthbert BN. Studying Hallucinations Within the NIMH RDoC Framework. Schizophr Bull. 2014 Jul;40 (Suppl 4):S295-304. PMID: 4141312

Cuthbert BN. Response to Lilienfield, Behaviour Research and Therapy. Behav Res Ther. 2014 Nov;62:140-2. PMID: 25294624

Casey BJ, Oliveri ME, Insel T. A neurodevelopmental perspective on the Research Domain Criteria (RDoC) framework. Biol Psychiatry. 2014 Sep 1; 76(5): 350-3. PMID: 25103538

Etkin A, Cuthbert B. Beyond the DSM: Development of a transdiagnostic psychiatric neuroscience course. Acad Psychiatry. 2014 Apr; 38(2): 145-50. PMID: 24493358

Cuthbert BN. Research domain criteria: Toward future psychiatric nosology. Asian Journal of Psychiatry. 2014; 7:4-5.

Cuthbert BN. NIMH RDoC Workgroup. The RDoC framework: Continuing commentary. World Psychiatry. 2014 Jun; 13(2): 196-7. PMCID: PMC4102294

Cuthbert BN. The RDoC framework: Facilitating transition from ICD/DSM to approaches that integrate neuroscience and psychopathology. World Psychiatry. 2014 Feb; 13(1): 28-35. PMCID: PMC2918011

Simmons JM, Quinn KJ. The NIMH Research Domain Criteria (RDoC) Project: Implications for genetics research. Mamm Genome. 2014 Feb;25(1-2): 23-31.PMID: 24085332

Morris SE, Rumsey JM, Cuthbert BN. Rethinking mental disorders: the role of learning and brain plasticity. Restor Neurol Neurosci. 2014;32(1): 5-23. PMID: 23902986


Cuthbert BN, Kozak MJ. Constructing constructs for psychopathology: The NIMH research domain criteria. J Abnorm Psychol. 2013 Aug;122(3):928-37. PMID: 24016027

Cuthbert BN, Insel TR. Toward the future of psychiatric diagnosis: the seven pillars of RDoC. BMC medicine. 2013;11:126. PMCID: PMC3653747


Morris SE, Cuthbert BN. Research Domain Criteria: Cognitive systems, neural circuits, and dimensions of behavior. Dialogues Clin Neurosci. 2012 Mar;14(1):29-37. PMCID: PMC3341647


Cuthbert B, Insel T. The data of diagnosis: New approaches to psychiatric classification. Psychiatry. 2010 Winter;73(4):311-314. PMID: 21198381

Sanislow CA, Pine DS, Quinn KJ, Kozak MJ, Garvey MA, Heinssen RK, Wang PS, Cuthbert BN. Developing constructs for psychopathology research: Research domain criteria. J Abnorm Psychol. 2010 Nov;119(4):631-9. PMID: 20939653

Cuthbert BN, Insel TR. Toward new approaches to psychotic disorders: The NIMH Research Domain Criteria project. Schizophr Bull. 2010 Nov;36(6):1061-2. Epub 2010 Oct 7. PMCID: PMC2963043

Cuthbert BN, Insel TR. New directions in diagnosis: Research domain criteria and global mental health. In E. Sorel (Ed.), 21st century global mental health. Burlington, MA: Jones & Bartlett. 2010. (pp. 55-70).

Insel T, Cuthbert B, Garvey M, Heinssen R, Pine DS, Quinn K, Sanislow C, Wang P. Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders. Am J Psychiatry. 2010 Jul;167(7):748-51. PMID: 20595427

Cuthbert, BN & Insel, TR. Classification issues in women's mental health: Clinical utility and etiological mechanisms. Arch Womens Ment Health. 2010 Feb;13(1):57-9. PMID: 20058041


Insel, TR & Cuthbert, BN. Endophenotypes: Bridging genomic complexity and disorder heterogeneity. Biological Psychiatry. 2009 Dec 1;66(11), 988-9. PMID: 19900610