CNS Radiotracer Table
CNS Radiotracers that have been advanced for use in Human Studies | |||
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Molecular Target | 11C-Labeled ligand | 18F-Labeled ligand | 123I-Labeled ligand |
Aggregated protein target |
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β-Amyloid |
[11C]PIB |
[18F]Flutemetamol [18F]Florbetapir([18F]AV-45) [18F]AZD 4694 [18F]FBM [18F]FDDNP [18F]-SMIBR-W372 ([F-18]-W372) [18F]Florbetaban [18F]MK3328 |
[123I]IMPY |
Tau/Synuclein
|
|
[18F]BF-227 [18F]THK523 |
|
Channel target |
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TSPO |
[11C](R)-PK 11195 [11C]PBR28 [11C]DAA1106 [11C]DPA-713 |
[18F]FBR [18F]FEPPA [18F]PBR111 |
[123I]CLINDE |
Enzyme target |
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AChE |
[11C]MP4A |
[123I]IBVM |
|
Aromatase |
[11C]VOR |
||
FAAH |
[11C]CURB |
||
MAO-A |
[11C]Harmine [11C]Clorgyline [11C]Befloxatone |
||
MAO-B |
[11C]Deprenyl-d2 |
||
PDE4 |
[11C](R)-Rolipram |
||
PDE10A |
[11C]IMA107 |
[18F]MNI659 |
|
Neuroreceptor target |
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Adenosine A1 |
[18F]CPFPX |
||
Adenosine A2A |
[11C]SCH442416 |
[123I]MNI420 |
|
Bz(GABAA) |
[11C]Flumazenil |
[18F]Flumazenil |
|
Bz (α5GABAA) |
[11C]Ro15 4513 |
||
CB1 |
[11C]MePPEP [11C]OMAR [11C]SD5024 |
[18F]FEMMEP-d2 [18F]MK-9470 |
|
D1 |
[11C]NNC 112 [11C]SCH 23390 |
||
D2/D3 |
[11C]Raclopride [11C]FLB 457 [11C]MNPA (agonist) [11C](+)PHNO (agonist) [11C]NPA (agonist) |
[18F]Fallypride |
[123I]IBZM [123I]Epidepride |
H1 |
[11C]Doxepin |
||
H3 |
[11C]GSK189254 [11C]GR 103545 |
[18F]FMH3 |
|
5-HT1A |
[carbonyl-11C]WAY [carbonyl-11C]DWAY [11C]CUMI (antagonist) |
[18F]FCWAY [18F]MefWAY [18F]MPPF |
|
5-HT1B |
[11C]AZ10419369 [11C]P943 |
||
5-HT2A |
[11C]MDL 1000907 |
[18F]Altanserin [18F]Altanserin-d2 |
|
5-HT4 |
[11C]SB-207145 |
||
5-HT6 |
[11C]GSK-215083 |
||
mGluR1 |
[11C]FIMX |
[18F]FITM |
|
mGluR5 |
[11C]SP 203 [11C]ABP688 |
[18F]SP 203 [18F]F-FPEB |
|
Nicotinic (α4β2) |
2-[18F]F-A-85380 (2-[18F]FA) 6-[18F]FA [18F]Nifene (agonist) [18F]AZAN |
[123I]5IA |
|
Nicotinic (α7) |
[11C]CHIBA-1001 [18F]ASEM |
||
NK1 |
[18F]SPA-RQ [18F]MK-0999 ([18F]FE-SPA-RQ) |
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NMDA | [18F]GE-179 | ||
NOP |
[11C]NOP-1A |
||
Opiate (DOR) |
[11C]Methylnaltrindole |
||
Opiate (MOR) |
[11C]Diprenorphine [11C]Carfentanil (agonist) |
[18F]Fluoroethyl-diprenorphine |
|
Sigma |
[11C]SA4503 |
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Transporter target |
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DAT |
[11C]PE2I [11C]Methylphenidate |
[18F]FP-CIT [18F]FE-PE2I [18F]FECNT |
[123I]FP-CIT (DATSCAN) [123I]CIT (Dopascan) [123I]Altropane [123I]PE2I |
Glycine T1 |
[11C]CFpyPB [11C]GSK 931145 |
[18F]CFPyPB |
|
NET |
[11C]MeNER-d2 |
[18F]FMeNER-d2 |
[123I]INER |
SERT |
[11C]DASB [11C]MADAM [11C]AFM [11C]HOHMADAM |
[123I]CIT [123I]mZIENT |
|
VMAT2 |
[11C]DTBZ |
[18F]florbenazine |