Armin Raznahan, M.D., Ph.D.
The Section on Developmental Neurogenomics (SDN) is dedicated to better understanding the biology of childhood-onset neuropsychiatric disorders in ways that might ultimately help to improve disease prediction, detection, and treatment. Together with our collaborators, we work towards this goal in three mutually informative ways.
First, we study rare genetic disorders that increase risk for mental health difficulties. These disorders are important medical conditions in their own right, and also shed broader light on mechanisms of biological risk in psychiatry. Affected individuals and their family members attend the NIH Clinical Center as outpatients for detailed assessments of mental health cognitive functioning, brain organization and cellular functioning. We use these rich data to inform clinical care and computationally reconstruct genetic influences in the developing human brain.
Second, we study sex as a neurobiological variable that influences mental health outcomes in the general population. This influence likely reflects a complex mix of biological, psychological and social factors – and our research carefully distinguishes between the biological concept of sex and the societal construct of gender. We use a combination of behavioral, neuroimaging and postmortem data to map normative sex-differences in the human brain and test if these intersect with the biology of neuropsychiatric disorders.
Third, we create and apply new tools that bridge different levels of human brain research. The human brain can be mapped in large numbers of individuals using neuroimaging, but this approach provides little cellular or molecular information. Conversely, the postmortem approaches that uncover microscopic features rely on small groups and typically focus on a subset of brain regions. We therefore develop and apply tools for the integration of human neuroimaging and postmortem data – to combine the best of both methods and build more holistic “multiscale” models of the human brain in health and disease.
Armin Raznahan, MD, PhD, is a child and adolescent psychiatrist, and Chief of the Section on Developmental Neurogenomics (SDN). His research combines neuroimaging, genomic and bioinformatic techniques to better understand the architecture of human brain development in health, and in neurogenetic disorders that increase risk for psychiatric symptoms. Dr. Raznahan completed his undergraduate and graduate training in London, UK (Medicine and Pediatrics at King’s College University/Hospital; Psychiatry at the Maudsley Hospital), and then trained as a postdoctoral fellow with Drs. Jay Giedd and Judith Rapoport at the NIMH Intramural Research Program. Dr. Raznahan joined the NIH-Lasker Clinical Research Scholars Program in 2015 and became a tenured Senior Investigator at the NIMH IRP in 2020.
Dr. Raznahan is a member of the UK Royal Colleges of Pediatrics (MRCPCH) and Psychiatry (MRCPsych), and a fellow of the American College of Neuropsychopharmacology (ACNP). He has served as an editor for the Journal of the American Academy of Child and Adolescent Psychiatry, and NeuroImage, and also sat on the ACNP Diversity and Inclusion Task Force, the ACNP Membership Committee, the AXYS (Association for X- and Y-Chromosome Variations) Advisory Committee, the Organization for the Study of Sex Differences Council, and the French Autism and Neuro-Developmental Disorders Scientific Advisory Board. The SDN has been recognized by awards from the NIMH Director (Outstanding Mentorship and Scientific Contributions), ACNP (Eva King-Killam Award for Translational Research) and the American Psychopathological Association (Robins-Guze Award).
Lee NR, Niu X, Zhang F, Clasen LS, Kozel BA, Smith ACM, Wallace GL, Raznahan A (2022). Variegation of autism related traits across seven neurogenetic disorders. Transl Psychiatry 12, 149. https://doi.org/10.1038/s41398-022-01895-0. [Pubmed Link]
Mallard TT, Liu S, Seidlitz J, Ma Z, Moraczewski D, Thomas A, Raznahan A (2021). X-chromosome influences on neuroanatomical variation in humans. Nat Neurosci 24, 1216-1224. https://doi.org/10.1038/s41593-021-00890-w. [Pubmed Link]
Liu S, Seidlitz J, Blumenthal JD, Clasen LS, Raznahan A (2020). Integrative structural, functional, and transcriptomic analyses of sex-biased brain organization in humans. Proc Natl Acad Sci U S A 117, 18788-18798. https://doi.org/10.1073/pnas.1919091117. [Pubmed Link]
Reardon PK, Seidlitz J, Vandekar S, Liu S, Patel R, Park MTM, Alexander-Bloch A, Clasen LS, Blumenthal JD, Lalonde FM, Giedd JN, Gur RC, Gur RE, Lerch JP, Chakravarty MM, Satterthwaite TD, Shinohara RT, Raznahan A (2018). Normative brain size variation and brain shape diversity in humans. Science 360, 1222-1227. https://doi.org/10.1126/science.aar2578. [Pubmed Link]
Raznahan A, Parikshak NN, Chandran V, Blumenthal JD, Clasen LS, Alexander-Bloch AF, Zinn AR, Wangsa D, Wise J, Murphy DGM, Bolton PF, Ried T, Ross J, Giedd JN, Geschwind DH (2018). Sex-chromosome dosage effects on gene expression in humans. Proc Natl Acad Sci U S A 115, 7398-7403. https://doi.org/10.1073/pnas.1802889115. [Pubmed Link]
Magnuson Clinical Center, Room 4N242, MSC 1367
BETHESDA, MD 20814
Phone: +1 301 435 7927
Fax: +1 301 402 0296