Stefano Marenco, M.D.
Human Brain Collection Core (HBCC)
Dr. Marenco is a Senior Research Clinician and the Acting Director of the Human Brain Collection Core (HBCC) in the Division Intramural Research Programs (IRP) at the National Institute of Mental Health. He completed his MD at the University of Genova, Italy, followed by training in Clinical Neurophysiology, and a residency in Psychiatry at the University of Maryland and the NIMH IRP. He has had further research training at Johns Hopkins University (with Dr. Dean Wong), and at the Clinical Brain Disorders Branch (CBDB), NIMH IRP (with Dr. Danny Weinberger).
In 2004 he became a staff clinician at CBDB, then transitioned to the Clinical and Translational Neuroscience Branch in 2011 (with Dr. Karen Berman). He became Deputy Director of the HBCC in 2016 (with Dr. Barbara Lipska). He has been Acting Director of HBCC since 2020.
Dr. Marenco has broad interests in neurophysiology, neurodevelopment, genomics, and biomarkers of mental illness, particularly schizophrenia.
Dr. Marenco has broad experience with a full spectrum of methodology to study brain physiology, neurological disorders, and psychiatric disorders. To characterize abnormalities in psychiatric patients and attempt to understand the genetic and environmental roots of psychiatric disorders, he has conducted clinical trials, and used brain imaging in vivo (PET, EEG, fMRI, MR spectroscopy, DTI) and genomic techniques postmortem. Dr. Marenco has primarily focused on schizophrenia research, but has expanded to other disorders since joining HBCC.
Duncan, L., H. Shen, A. Schulmann, T. Li, B. Kolachana, A. Mandal, N. Feng, P. Auluck and S. Marenco (in press). "Polygenic Scores for Psychiatric Disorders in a Diverse Postmortem Brain Tissue Cohort." Neuropsychopharmacology.
Sudre, G., D. E. Gildea, G. G. Shastri, W. Sharp, B. Jung, Q. Xu, P. K. Auluck, L. Elnitski, A. D. Baxevanis, S. Marenco and P. Shaw (2022). "Mapping the cortico-striatal transcriptome in attention deficit hyperactivity disorder." Mol Psychiatry. [Pubmed Link]
Convergence of placenta biology and genetic risk for schizophrenia. Ursini, G., Punzi, G., Chen, Q., Marenco, S., Robinson, J. F., Porcelli, A., Hamilton, E. G., Mitjans, M., Maddalena, G., Begemann, M., Seidel, J., Yanamori, H., Jaffe, A. E., Berman, K. F., Egan, M. F., Straub, R. E., Colantuoni, C., Blasi, G., Hashimoto, R., Rujescu, D., Ehrenreich, H., Bertolino, A. and Weinberger, D. R. (2018). Nat Med 24(6): 792-801. [Pubmed Link]
Prefrontal GABA Levels Measured With Magnetic Resonance Spectroscopy in Patients With Psychosis and Unaffected Siblings. Marenco, S., Meyer, C., Kuo, S., van der Veen, J. W., Shen, J., DeJong, K., Barnett, A. S., Apud, J. A., Dickinson, D., Weinberger, D. R. and Berman, K. F. (2016). Am J Psychiatry 173(5): 527-534 [Pubmed Link]
Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome. Marenco, S., Siuta, M. A., Kippenhan, J. S., Grodofsky, S., Chang, W. L., Kohn, P., Mervis, C. B., Morris, C. A., Weinberger, D. R., Meyer-Lindenberg, A., Pierpaoli, C. and Berman, K. F. (2007). Proc Natl Acad Sci U S A 104(38): 15117-15122. [Pubmed Link]
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