Daniel Zaldivar, MD, PhD
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National Institute of Mental Health Building 49, Room B1C60, 49 Convent Dr. Bethesda, MD 20892 phone (+1) · 301 · 827 · 5082 daniel.zaldivarperez@nih.gov
RESEARCH INTEREST
My interest lies in understanding the role of neuromodulatory ascending pathways. How they mediate our ability to process the influx of information, make decision, and take appropriate action. I used the high-level vision as a model system to explore how social behaviors are influenced by neuromodulatory inputs (e.g. cholinergic, dopaminergic). To explore this ideas, I used simultaneous fMRI, large-scale neurophysiology and direct neural perturbation methods, in combination with anatomical methods to increase our understanding about the anatomo-functional relationship of neuromodulatory inputs in the brain and their influence. This likely will help set new foundation to ameliorate disorders of the mind.
EDUCATION & TRAINING
National Institute of Mental Health (NIMH), Since July 2018
National Institute of Health (NIH), Bethesda, U.S.A
Postdoctoral Fellow at the Cognitive Neurophysiology and Imaging Laboratory Supervisor: Dr. David Leopold
Project: Functional mapping of basal forebrain projections in monkeys
Max Planck Institute for Biological Cybernetics & Aug. 2009 - Jun. 2017
University of Tubingen, Tubingen, Germany Ph.D. in Systems and Cognitive Neuroscience Supervisor: Prof. Nikos Logothetis
Project: Effects of neuromodulation on neurovascular coupling
National Polytechnic Institute, Mexico City, Mexico Aug. 2009
M.D. and Surgeon
Supervisor: Dr. Alfonso Barbara & Dr. Jorge Sanchez Project: The clinical relevance of the mirror neurons system
FUNDING
2018 - pres. IRTA Fellowship by the National Institute of Mental Health (NIMH )
2018 - 2021 Research Fellowship by the German Research Foundation (DFG: ZA990/1-1; 642452 )
2017 Travel Grant by the Erice School Camillo Golgi, “from cell physiology to integrated signals and emerging brain function”, Erice, Italy.
2009 - 2016 Ph.D. Candidate Fellowship by the Max Planck Society & the Max Planck Institute for Biological Cybernetics, Tu¨bingen, Germany
2015 Travel Grant by the International Society for Magnetic Resonance in Medicine (ISMRM: 79886 ), Ontario, Toronto-Canada
2012 Travel Grant for the Training Course on Advance Statistical Modeling of Neuronal Data 2008 - 2009 Medicine Graduates Fellowship by the Secretary of Health (SSA), Mexico
2004 - 2007 Research Training Scholarship by National Council for Science and Technology (CONA- CyT ), Mexico
HONORS & AWARDS
2019 National Institute of Mental Health, IRP-OFT Trainee Travel Award
2017 “Best Dissertation Award 2017” from the Forderverein fur neurowissenschaftliche Forschung e.V., Tubingen, Germany
2017 “Magna Cum Laude”, International Max Planck Research School, Tubingen, Germany
2015 “Summa Cum Laude”, (Outstanding Scientific Work), International Society for Magnetic Resonance in Medicine (ISMRM)
2014 Leadership Award and Travel Grant from Novartis International Biotechnology Leadership Camp (BioCamp 2014), Basel-Switzerland
2008 Medical Student Prize for Excellence, Pfizer Science Centre, Mexican Academy of Medicine, Mexican Association of Medical School and Faculties (AMFEM), National Council for Science and Technology (CONACyT). Mexico
2007 1st. Place Award from the National Youth Contest of Science and Technology 2007. Mexican Academy of Science
ORIGINAL RESEARCH ARTICLES
The prime Data and Resource Consortium (PRIME-DRE). Towards next-generation primate neuro- science: A collaboration-based strategic plan for integrative neuroimaging. Neuron (2022) Jan 5;110(1):16-20. PMID: 34731649 .
Zaldivar D, Rauch A, Logothetis NK & Goense J. Two distinct profiles of fMRI and neurophysiological activity elicited by acetylcholine in visual cortex. Proc Natl Acad Sci U S A. (2018) Dec 18;115(51):E12073-E12082. PMID: 30510000 .
Zaldivar D, Goense J, Lowe SC, Logothetis NK & Panzeri S. Dopamine Is Signaled by Mid-frequency Oscillations and Boosts Output Layers Visual Information in Visual Cortex. Curr Biol. (2018) Jan 22;28(2):224-235.e5. PMID: 2018/01/09 06:00 .
Fichtner ND, Giapitzakis IA, Avdievich N, Mekle R, Zaldivar D, Henning A & Kreis R. In vivo characterization of the downfield part of 1 H MR spectra of human brain at 9.4 T: Magnetization ex- change with water and relation to conventionally determined metabolite content. Magn Reson Med. (2018) Jun;79(6):2863-2873. PMID: 29034505 .
Zaldivar D, Logothetis NK, Rauch A & Goense J. Pharmaco-Based fMRI and Neurophysiology in Non-Human Primates. In: In vivo Neuropharmacology and Neurophysiology, (Ed) Athineous Philippou. Neuromethods of Springer Science Series (2017) Oct 22:37-66 .
Zaldivar D, Rauch A, Whittingstall K, Logothetis NK & Goense J. Dopamine-induced dissociation of BOLD and neural activity in macaque visual cortex. Curr Biol. (2014) Dec 1;24(23):2805-11. PMID: 25456449 .
von Pf¨ostl V*, Li J*, Zaldivar D, Goense J, Zhang X, Serr N, Logothetis NK & Rauch A. Effects of lactate on the early visual cortex of non-human primates, investigated by pharmaco-MRI and neuro- chemical analysis. Neuroimage. (2012) May 15;61(1):98-105. PMID: 22426350 .
Li J*, von Pf¨ostl V*, Zaldivar D, Zhang X, Logothetis N & Rauch A. Measuring multiple neuro- chemicals and related metabolites in blood and brain of the rhesus monkey by using dual microdialysis sampling and capillary hydrophilic interaction chromatography-mass spectrometry. Anal Bioanal Chem. (2012) Mar;402(8):2545-54. PMID: 21956265 .
Gonz´alez, G*, Zaldıvar, D*, Carrillo, E, Hernandez, A, Garcıa, M & Sanchez, J. Pharmacological preconditioning by diazoxide downregulates cardiac L-type Ca(2+) channels. Br. J. Pharmacol. (2010) 161, 1172–1185. doi: 10.1111/j.1476-5381.2010.00960.x
Zaldivar D, Garc´ıa MC & S´anchez JA. Ciliary neurotrophic factor promotes inactivation of muscle Ca2+ channels via PKC. Biochem Biophys Res Commun. (2005) Dec 23;338(3):1572-7. PMID: 16274672 .
MANUSCRIPTS CURRENTLY UNDER REVIEW OR IN PREPARATION
Zaldıvar D, Koyano K, Ye F, Park S, Bhik-Ghanie R, Godlove D & Leopold D. Brain-wide coupling of single face patch neurons at rest. (in prep.)
Lowe S, Zaldivar D, Murayama Y, Logothetis NK & Panzeri S. Lamina and frequency distribution of information in primary visual cortex. (in prep.).
Zaldivar D, Logothetis NK & Goense J. Layer dependent differences in neural activity under positive and negative BOLD conditions. (in prep.).
PUBLISHED MEETING ABSTRACTS
2022
Zaldivar D, Koyano K, Ye F, Park S, Godlove D & Leopold D. & Leopold DA. Differential coupling between single-unit fMRI and other seed-based maps. 7th CiNet. Kyoto, Japan. (POSTER)
2021
Bhik-Ghaine R, Zaldivar D, & Leopold DA. Using fMRI to map spontaneous activity of single neurons.
IRP Fellow Scientific Training Day, NIMH, NIH. Washington DC, USA. (POSTER)
2020
Zaldivar D, Koyano K, Godlove D & Leopold DA. Whole-brain fMRI mapping of neural activity recorded from a single voxel. FENS forum of Neuroscience, Glasgow, UK. (POSTER)
2019
Zaldivar D, Koyano K & Leopold DA. Local and global correlations of spontaneous electrophysio- logical activity measured from a single fMRI voxel. IRP Fellow Scientific Training Day, NIMH, NIH. Washington DC, USA. (POSTER)
2018
Murali-Manohar SV, Borbath T, Fichtner N, Giapitzakis IA, Zaldivar D, Kreis R, & Henning A. Estimation of T2 Relaxation Times of Downfield Peaks in Human Brain at 9.4 T. Joint Annual Meeting ISMRM-ESMRMB, Paris, France. (POSTER)
2017
Zaldivar D, Rauch A, Logothetis N & Goense J. Effects of cholinergic neuromodulation on fMRI and neural responses in macaque visual cortex. Neuromodulation of Neural Microcircuits (NM2). Blue Brain Conference, Lausanne, Geneva, Switzerland. (POSTER)
Paßlack U, Lara E, Logothetis N & Zaldıvar D. In vivo real time-coupled electrical and electrophys- iological signals detection using MR compatible multi-modal probes in rodents (NM2). Blue Brain Conference, Lausanne, Geneva, Switzerland. (POSTER)
Damara-Fichtner N, Giapitzakis IA, Avdievich N, Mekle R, Zaldivar D, Henning A & Kreis R. Mod- elling of the downfield spectrum for exchange rates and T1 values in human brain at 9.4T. Joint Annual Meeting ISMRM-ESMRMB, Honolulu, Hawaii, USA. (POSTER)
Damara-Fichtner N, Giapitzakis IA, Avdievich N, Mekle R, Zaldivar D, Henning A & Kreis R (2017). Measuring exchange between brain metabolites and water using ultra-high field magnetic Resonance Spectroscopy. GCB Symposium. Universitat Bern, Switzerland. (TALK)
2016
Zaldıvar D, Goense J, Lowe S, Logothetis NK & Panzeri S. Dopamine elicits lamina- and frequency specific increase of information in the local field potentials of macaque V1. SfN’s 46th Annual Meeting. San Diego California, USA. (POSTER)
2015
Zaldıvar D, Logothetis NK & Goense J. Laminar differences in neural activity during positive and negative BOLD conditions. Annual Meeting ISMRM, Toronto, Ontario, Canada. (TALK)
2014
Lowe S, Zaldivar D, Murayama Y, Logothetis NK & Panzeri S. Different cortical layers in V1 encode different visual information in different frequency bands. SfN’s 44th Annual Meeting. Washington DC, USA. (POSTER)
Lowe S, Zaldıvar D, Murayama Y, Logothetis NK & Panzeri S. Quantification of the laminar and frequency structure of information in primary visual cortex. 9th FENS, Forum of Neuroscience. Milan- Italy. (POSTER)
2012
Zaldıvar D, Li J, vonPfoestl V, Whittingstall K, Rauch A & Logothetis NK. The modulatory role of dopamine in the early visual system of macaques investigated by fMRI, neurochemistry and neuro- physiology. 8th FENS, Forum of Neuroscience. Barcelona-Spain. (POSTER)
vonPfoestl V, Zaldıvar D, Li J, Viswanath S, Zhang X, Logothetis NK & Rauch A. Electrophysiological effects of lactate on primary visual cortex on non-human primates. Veronika vonPfoestl, 8th FENS, Forum of Neuroscience. Barcelona-Spain. (POSTER)
2011
Li J*, Zaldıvar D*, vonPfoestl V, Zhang X, Logothetis NK & Rauch A. Targeted tissue sampling and imaging in non-human primates brain with microdialysis and fMRI. European Foundation for Clinical Nanomedicine, Basel, Switzerland. (POSTER)
Zaldıvar D, Li J, vonPfoestl V, Zhang X, Logothetis NK & Rauch A. Dopaminergic modulation of the early visual system of non-human primates and its underlying neuronal and hemodynamic changes. SfN‘s 41th Annual Meeting, Washington DC, USA. (POSTER)
Li J*, Zaldıvar D*, vonPfoestl V, Serr N, Zhang X, Logothetis NK & Rauch A. Nicotinic modulation of early visual system and its underlying neuronal and metabolic changes. SfN‘s 41th Annual Meeting, Washington DC, USA. (POSTER)
2010
Li J*, vonPfoestl V*, Zaldıvar D, Zhang X, Logothetis NK & Rauch A. Comparing concentration levels of multiple neurochemically active compounds in the blood and brain tissue of non-human pri- mates by using dual microdialysis sampling and capillary hydrophilic interaction chromatography mass spectrometry. SfN‘s 40th Annual Meeting, San Diego California, USA. (POSTER)
vonPfoestl V, Li J, Zaldıvar D, Zhang X, Logothetis NK & Rauch A. Effects of lactate in primary visual cortex of non-human primates investigated by pharmaco-MRI and neurochemical analysis. SfN‘s 40th Annual Meeting, San Diego California, USA. (POSTER)
Gonzalez G*, Zaldıvar D*, Carrillo E, Garcia MC & Sanchez JA. The cardiac α1C subunit is down- regulated by pharmacological preconditioning. 54th Annual Meeting Biophysical Society, San Francisco California, USA. (POSTER)
2008
Zaldıvar D, Gonzalez G, Carrillo E, Garcıa MC & Sanchez JA. Down regulation of the L-type Ca2+ channel by pharmacological preconditioning in mammalian heart. 52nd Annual Meeting of the Bio- physical Society, Long Beach California, USA. (POSTER)
Zaldıvar D, Gonzalez G, Carrillo E, Garcıa MC & Sanchez JA. Down regulation of the L-type Ca2+ channel by pharmacological preconditioning in mammalian heart. LI National Congress of Physiologi- cal Sciences by Mexican Society of Physiological Sciences. (TALK)
2007
Gonzalez G, Carrillo E, Zaldıvar D, Hernandez A, Garcıa MC & Sanchez JA. Increased interaction between PKC and the rat L-Type Calcium Channel in an ischemic preconditioning model. International Congress Medichem-FeNaSTAC 2007, Mexico City, Mexico. (POSTER)
Carrillo E, Escobar Y, Zaldıvar D & Sanchez JA. Differential expression of β2 Ca2+ channels subunit isoforms in adults and rat heart cells. 51st Annual Meeting of the Biophysical Society, Baltimore Maryland USA. (POSTER)
2006
Carrillo E, Escobar Y, Zaldıvar D & Sanchez JA. Expression of different isoforms of β2 subunit of L type Ca2+ channels in cardiac muscle cells in neonatal and adult rats. XXVI Meeting of the Mexican Society of Biochemistry, Guanajuato, Mexico. (POSTER)
Zaldıvar D, Garcıa MC & Sanchez JA. Modulation of L-type Ca2+ channels of adult mouse skeletal muscle by the ciliary neurotrophic factor. 50th Annual Meeting of the Biophysical Society, Salt Lake City Utah, USA. (POSTER)
INVITED PRESENTATIONS & SEMINARS
2022
May 19, 2022, Fellow’s Afternoon Neuroscience Seminar, National Institute of Mental Health, National Institute of Health, USA, “Brain-wide coupling of single face patch neurons during rest”.
2021
May 20, 2021, Fellow’s Afternoon Neuroscience Seminar, National Institute of Mental Health, National Institute of Health, USA, “Diversity of functional networks observed in a single voxel”.
May 18, 2021, Institute of Behavioural Neuroscience at University College London (UCL), UK, “Whole brain fMRI mapping of neural activity recorded from a single voxel”.
2019
December 19, 2019, Fellow’s Afternoon Neuroscience Seminar, National Institute of Mental Health, National Institute of Health, USA, “Local and global correlations of spontaneous electrophysiological activity measured from a single fMRI voxel”.
2017
December 02, 2017, School of Brain Cells and Circuits “Camillo Golgi”, Ettore Majorana Foundation and Centre for Scientific Culture, Erice, Italy, “SnapShot on Neuromodulation and neurovascular coupling.”
November 30, 2017, School of Brain Cells and Circuits “Camillo Golgi”, Ettore Majorana Foundation and Centre for Scientific Culture, Erice, Italy, “Effects of Neuromodulation on neurovascular coupling.”
2015
November 20, 2015, National Institute of Health, Bethesda, MD, USA, “Effects of neuromodulation on neurovascular coupling”.
June 30, 2015, Universitare Psychiatrische Dienste Bern, Switzerland, “Dopamine-induced dissociations of BOLD and neural activity”.
June 3, 2015, McGovern Institute for Brain Research: Massachusetts Institute of Technology, Cam- bridge, MA, USA, “The effects of neuromodulation on the neurovascular coupling.”
January 13, 2015, Instituto de Neurobiologıa, UNAM, Queretaro, Mexico, “Neural mechanisms underlying fMRI signals and the role of neuromodulation at shaping neurovascular-coupling relationship.”
2014
August 13, 2014, Donders Institute, Nijmegen, Netherlands, “Mid-frequency oscillations in visual cortex of monkeys are sensitive to neuromodulation.”
2012
February 12, 2012, Leibniz Institute for Neurobiology, Magdeburg, Germany, “Dopaminergic neuro- modulation of early visual system of macaques investigated by fMRI, neurophysiology and neurochemistry.”
2011
September 9, 2011, Conference Networks, University of Tubingen, “Pharmacological approach for neuromodulation.”
2010
August 9, 2010, National Polytechnic Institute, Mexico City, “Cracking the neural code for sensory perception: the self-modulation of neural circuits.”
2006
June 27, 2006, National Polytechnic Institute, Mexico City, “Ion channels and cancer.” - January 19, 2006, National Polytechnic Institute, Mexico City, “Biochemistry and biophysics of ion channels.”
INSTITUTIONAL SERVICE
2019 - 2020 NIH Post-bac Poster Day Judge
2020 - 2021 NIH Graduate Students Symposium Poster Judge
2018 - 2019 Guest Scientist at the Max Planck Institute for Biological Cybernetics, Tubingen Germany 2015 - 2017 Named Project Leader by the Regierungsprasidium Tubingen, Germany (KY4/09 & KY4/16) 2011 - 2014 Named Project Leader by the Regierungsprasidium Tubingen, Germany (KY7/14)
2007 - 2009 Medical Intern at General Hospital, Carlos MacGregor, Mexico City.
MENTORING
2020 - pres. Rebecca Bhik-Ghaine, Postbac
Mentored as part of NIH intramural program for post-baccalaureate Project: Optogenetical stimulation in basal forebrain
2015 - 2017 Ulrike Passlack, Master Thesis
Co-mentored in cooperation with the University of Ulm, Germany
Project: A multimodal probe for the simultaneous multisite recordings of neurophysiological and electrochemical events in the rodent brain.
Currently: PhD student at the Institut fur Mikroelektronische Systeme (INES), Universitat Stuttgart, Germany
2011 - 2012 Sneha Eberhardt (Vismanath), Master Thesis
Co-mentored in cooperation with the University of Tubingen, Germany Project: Role of Adenosine in Neurovascular Coupling.
Currently: Business development manager, artificial intelligence and diagnostics at Siemens Healthineers, Germany.
PROFESSIONAL AFFILIATIONS
Society of Neuroscience (SfN)
Federation of European Neuroscience (FENS) German Society of Neuroscience Neuroinformatics
AD HOC JOURNAL REVIEW
Current Biology (Cell Press) Journal of Chemical Neuroanatomy
Scientific Reports (Nature Publishing Group) NeuroImage
Journal of Psychopharmacology Frontiers of Human Neuroscience Frontiers of Neural Circuits
International Journal Neuropsychopharmacology (Oxford University Press) European Neuropsychopharmacology
Neuropsychopharmacology Human Brain Mapping