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Molecular Imaging Branch (MIB)

2020 Publications

Full Refereed Papers

L. Cai, J.S. Liow, C.L. Morse, S. Telu, R. Davies, M.P. Frankland, , S.S. Zoghbi, K. Cheng, M.D. Hall, R.B. Innis, V.W. Pike, Evaluation of 11C-NR2B-SMe and its enantiomers as PET radioligands for imaging the NR2B Subunit within the NMDA receptor complex in rats. J. Nucl. Med. (2020) 61, 1212-1220. DOI:10.2967/jnumed.119.235143. 

E.J. Jakobsson, S. Lu, S. Telu, V.W. Pike, [11C]Carbonyl difluoride‐a new and highly efficient [11C]carbonyl group transfer agent. Angew. Chem. Intl. Ed. (2020) 132, 7256-7260. DOI:10.1002/anie.201915414. 

S. Lu, M.B. Haskali, K.M. Ruley, N.J.-F. Dreyfus, S.L. DuBois, J.S. Liow, C.L. Morse, A. Kowalski, R.L. Gladding, J. Gilmore, A.J. Mogg, S.M. Morin, P. Lindsay-Scott, V.N. Barth, H.N. Nuthall, M.P. Johnson, M. Cuadrado, E. Jambrina, S.S. Zoghbi, R.B. Innis, C.D. Jesudason, V.W. Pike, PET ligands [18F]LSN3316612 and [11C]LSN3316612 quantify O-linked-β-N-acetyl-glucosamine hydrolase in the brain. Sci. Transl. Med. (2020) 12, Article ID aau2939. (Featured on cover). DOI:10.1126/scitranslmed.aau2939. 

G.M. Knudsen, M. Ganz, S. Appelhoff, R. Boellaard, G. Bormans, R.E. Carson, C. Catana, D. Doudet, A.D. Gee, D.N. Greve, R.N. Gunn, C. Halldin, P. Herscovitch, H. Huang, S.H. Keller, A.A. Lammertsma, R. Lanzenberger, J.S. Liow, T.G. Lohith, M. Lubberink, C.H. Lyoo, J.J. Mann, G.J. Matheson, T.E. Nichols, M. Nørgaard, T. Ogden, R. Parsey, V.W. Pike, J. Price, G. Rizzo, P. Rosa-Neto, M. Schain, P.J.H. Scott, G. Searle, M. Slifstein, T. Suhara, P.S. Talbot, A. Thomas, M. Veronese, D.F. Wong, M. Yaqub, F. Zanderigo, S. Zoghbi, R.B. Innis, Guidelines for the content and format of PET brain data in publications and archives: A consensus paper. J. Cereb. Blood Flow Metab. (2020) 40, 1576-1585. DOI:10.1177/0271678X20905433, 

J.-H. Lee, J.S. Liow, S. Paul, C.L. Morse, M.B. Haskali, L. Manly, S. Shcherbinin, J.C. Ruble, N. Kant, E.C. Collins, H.N. Nuthall, P. Zanotti-Fregonara, S.S. Zoghbi, V.W. Pike, R.B. Innis, PET quantification of brain O-GlcNAcase with [18F]LSN3316612 in healthy human volunteers. EJNMMI Res. (2020) 10, Article ID 20. DOI:10.1186/s13550-020-0616-4. 

L.D. Weidner, Y. Wakabayashi, L.A. Stolz, M.T. Collins, L. Guthrie, M. Victorino, J. Chung, W. Miller, S.S. Zoghbi, V.W. Pike, M. Fujita, R.B. Innis, A.M. Boyce, PET imaging of phosphodiesterase-4 identifies affected dysplastic bone in McCune-Albright syndrome, a genetic mosaic disorder. J. Nucl. Med. (2020) 61, 1672-1677. DOI:10.2967/jnumed.120.241976. 

M.-J. Kim, J.-H. Lee, F.J. Anaya, J. Hong, W. Miller, S. Telu, P. Singh, M.Y. Cortes, K. Henry, G.L. Tye, M.P. Frankland, J.A. Montero Santamaria, J.S. Liow, S.S. Zoghbi, M. Fujita, V.W. Pike, R.B. Innis, First-in human evaluation of [11C]PS13, a novel PET radioligand, to quantify cyclooxygenase-1 in the brain. Eur. J. Nucl. Med. Mol. Imaging. (2020) 47, 3143-3151. DOI:10.1007/s00259-020-04855-2. 

S. Jana, S. Telu, B.Y. Yang, , M.B. Haskali,. J.E. Jakobsson, V.W. Pike, Rapid Syntheses of [11C]arylvinyltrifluoromethanes through treatment of (E)-arylvinyl(phenyl)iodonium tosylates with [11C]trifluoromethylcopper(I). Org. Lett. (2020) 22, 4574–4578. DOI:10.1021/acs.orglett.0c01705. 

S. Shrestha, M.J. Kim, M. Eldridge, M.L. Lehmann, M. Frankland, J.S. Liow, Z-X. Yu, M. Cortes-Salva, S. Telu, I.D. Henter, E. Gallagher, J.-H. Lee, J.M. Fredericks, C. Poffenberger, G. Tye, Y. Ruiz-Perdomo, F.J. Anaya, J.A., Montero Santamaria R.L. Gladding, S.S. Zoghbi, M. Fujita, J.D. Katz, V.W. Pike, R.B. Innis, PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first in-human study. J. Neuroinflammation (2020) 17, Article ID 140. DOI:10.1186/s12974-020-01804-6. 

K.M. Ramos-Torres, Y.-P. Zhou, B.Y. Yang, N.J. Guehl, S.H. Moon, S. Telu, M.D. Normandin, V.W. Pike, P. Brugaralos, Syntheses of [11C]2- and [11C]3-trifluoromethyl-4-aminopyridine: potential PET radioligands for demyelinating diseases. RSC Med. Chem. (2020) 11, 1161-1167. (Featured on cover) DOI:10.1039/d0md00190b. 

N. Young, , V.W. Pike, C. Taddei, Rapid and efficient synthesis of [11C]trifluoromethylarenes from primary aromatic amines with [11C]CuCF3. ACS Omega (2020) 5, 19557-19564. DOI:10.1021/acsomega.0c02027. 

H.U. Shetty, S.S. Zoghbi, C.L. Morse, A. Kowalski, J. Hirvonen, R.B. Innis, V.W. Pike, Development of a non-radiometric method for measuring the arterial input function of a 11C-labeled PET radiotracer. Sci. Reports (2020) 10, article ID 17350. DOI:10.1038/s41598-020-73646-4. 

Y. Wakabayashi, S. Telu, R.M. Dick, M. Fujita, M. Ooms, C.L. Morse, J-S. Liow, J.S. Hong, R.L. Gladding, L.S. Manly, S.S. Zoghbi, X. Mo, E.C. D’Amato, J.A. Sindac, R.A. Nugent, B.E. Marron, M.E. Gurney, V.W. Pike, Discovery, radiolabeling, and evaluation of subtype-selective inhibitors for positron emission tomography imaging of brain phosphodiesterase-4D. ACS Chem. Neurosci. (2020) 11, 1311-1323. DOI:10.1021/acschemneuro.0c00077.