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Molecular Imaging Branch (MIB)

2023 Publications

Full Refereed Papers

M. Jiang, S. Lu, S. Telu, V.W. Pike, An empirical quantitative structure-activity relationship equation assists the discovery of high-affinity phosphodiesterase 4D inhibitors as leads to PET radioligands. J. Med. Chem. (2023) 66, 1543–1561. DOI:10.1021/acs.jmedchem.2c01745. 

M.-J. Kim, F.J. Anaya,. S. Manly, J.-H. Lee, J. Hong, S. Shrestha, S. Telu, K. Henry, J.A. Montero Santamaria, J.-S. Liow, P. Zanotti-Fregonara, H.U. Shetty, S.S. Zoghbi, V.W. Pike, R.B. Innis, Whole-body PET imaging in humans shows that 11C-PS13 is selective for cyclooxygenase-1 and can measure the in vivo potency of nonsteroidal antiinflammatory drugs. J. Nucl. Med. (2023) 64, 159-164. DOI:10.2967/jnumed.122.264061. 

L. Cai, J. Liow, C.L. Morse, S. Telu, R. Davies, L.S. Manly, S.S. Zoghbi, F.T. Chin, R.B. Innis, V.W. Pike, Candidate 3-benzazepine-1-ol type GluN2B receptor radioligands (11C-NR2B-Me enantiomers) have high binding in cerebellum but not to σ1 receptors. EJNMMI Res. (2023) 13, Article ID 28. DOI:10.1186/s13550-023-00975-6. 

X. Yan, F.G. Siméon, J.-S. Liow, C.L. Morse, J.A. Montero Santamaria, M. Jenkins, L.S. Manly, M. Van Buskirk, S.S. Zoghbi, V.W. Pike, R.B. Innis. P. Zanotti-Fregonara, In vivo evaluation of a novel 18F-labeled PET radioligand for translocator protein 18kDa (TSPO) in monkey brain. Eur. J. Nucl. Med. Mol. Imaging (2023) 50, 2962-2970. DOI:10.1007/s00259-023-06270-9. 

S. Telu, S. Jana, M.B. Haskali, B.Y. Yang, J. Jakobsson, Q. Zhao, K.M. Ramos-Torres, P. Brugarolas, V.W. Pike, Broad-scope syntheses of [11C/18F]trifluoromethylarenes from aryl(mesityl)iodonium salts. Chem. Eur. J. (2023) 29, Article ID e202204004. DOI:10.1002/chem.202204004. 

S. Altomonte, X. Yan, C.L. Morse, J.-S. Liow,. M.D. Jenkins, J.A. Montero Santamaria, S.S. Zoghbi, R.B. Innis, V.W. Pike, Discovery of a High-affinity fluoromethyl analog of [11C]5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide ([11C]CPPC) and their comparison in mouse and monkey as colony-stimulating factor 1 receptor positron emission tomography radioligands. ACS Pharmacol. Transl. Sci. (2023) 6, 614-632. DOI:10.1021/acsptsci.3c00003.