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CNS Radiotracer Table

CNS Radiotracers that have been advanced for use in Human Studies
Molecular Target 11C-Labeled ligand 18F-Labeled ligand 123I-Labeled ligand
Neuroreceptor target
Metabotropic
Adenosine A1 [11C]MPDX [18F]CPFPX
Adenosine A2A [11C]SCH442416 [18F]MNI-444 [123I]MNI-420
[11C]Preladenant
[11C]TMSX
CB1 [11C]MePPEP [18F]FEMMEP-d2
[11C]OMAR [18F]MK-9470
[11C]SD5024
D1 [11C]NNC 112 [18F]MNI-968 ([18F]PF-8477)
[11C]SCH 23390
D2/D3 [11C]Raclopride [18F]Fallypride [123I]IBZM
[11C]FLB 457 [123I]Epidepride
[11C]MNPA (agonist) [123I]IBF
[11C](+)PHNO (agonist)
[11C]NPA (agonist)
H1 [11C]Doxepin
H3 [11C]GSK189254 [18F]FMH3
[11C]GR 103545
5-HT1A [carbonyl-11C]WAY [18F]FCWAY
[carbonyl-11C]DWAY [18F]MefWAY
[11C]CUMI-101 [18F]MPPF
5-HT1B [11C]AZ10419369
[11C]P943
5-HT2A [11C]MDL 100 907 [18F]Altanserin
[18F]Altanserin-d2
[18F]Setoperone
5-HT4 [11C]SB-207145
5-HT6 [11C]GSK-215083
mGluR1 [11C]ITMM [18F]FIMX
mGluR5 [11C]ABP688 [18F]-FPEB
[18F]-​PSS232
NK1 [18F]SPA-RQ
[18F]MK-0999 ([18F]FE-SPA-RQ)
NOP [11C]NOP-1A
Opiate (DOR) [11C]Methylnaltrindole
Opiate (MOR) [11C]Diprenorphine [18F]Fluoroethyldiprenorphine
[11C]Carfentanil (agonist)
Opiate (KOR) ​[11C]GR103545 
[11C]LY2795050
Sigma [11C]SA4503
Imidazoline Receptors (I2 binding site) [11C]BU99008
Ionotropic
Bz(GABAA) [11C]Flumazenil [18F]Flumazenil
Bz (α5GABAA) [11C]Ro15 4513
Nicotinic (α4β2) 2-[18F]F-A-85380 (2-[18F]FA) [123I]51A
6-[18F]FA
[18F]Nifene (agonist)
[18F]XTRA
[18F]GMOM
[18F]Flubatine
[18F]AZAN
Nicotinic (α7) [11C]CHIBA-1001 [18F]ASEM
NMDA [18F]GE-179 [123I]CNS1261
P2X7 [11C]JNJ54173717 [18F]JNJ-64413739
[11C]GSK-1482160
Transporter target
DAT [11C]PE2I  [18F]FP-CIT [123I]FP-CIT (DATSCAN)
[11C]Methylphenidate [18F]FE-PE2I [123I]CIT (Dopascan)
[18F]FECNT [123I]Altropane
[123I]PE2I
Glycine T1 [11C]CFpyPB [18F]CFPyPB
[11C]GSK 931145
[11C]RO5013853
NET [11C]MeNER-d2 [18F]FMeNER-d2 [123I]INER
SERT [11C]DASB [18F]ADAM [123I]CIT
[11C]MADAM [123I]mZIENT
[11C]AFM [123I]norβCIT
[11C]HOHMADAM [123I]βCIT
[123I]ADAM
VMAT2 [11C]DTBZ [18F]florbenazine
[11C]MTBZ [18F]AV-133
[18F]FP-DTBZ
VAChT [18F]FEOBV
Synaptic Proteins
SV2A [11C]UCB-J  [18F]UCB-H  
[11C]UCB-A
 Channel like target
TSPO [11C](R)-PK 11195 [18F]FBR  [123I]CLINDE
[11C]PBR28 [18F]FEPPA
[11C]DAA1106 [18F]PBR111
[11C]DPA-713
 Enzyme target
AChE [11C]MP4A    [123I]IBVM
Aromatase [11C]VOR
Cox-1 [11C]PS13
FAAH [11C]CURB
[11C]MK3168
HDAC 1-3 [11C]Martinostat
MAO-A [11C]Harmine
[11C]Clorgyline
[11C]Befloxatone
MAO-B [11C]Deprenyl-d2
Mitochondrial Complex 1 [18F]BCPP-EF
PDE2A [18F]PF05270430
PDE4 [11C](R)-Rolipram
PDE10A [11C]IMA107 [18F]MNI659
[11C]MP-10
[11C]Lu AE92686
 Aggregated protein target
β-Amyloid [11C]PIB [18F]Flutemetamol  [123I]IMPY
[18F]Florbetapir([18F]AV-45)
[18F]AZD 4694
[18F]FBM
[18F]FDDNP
[18F]W372
[18F]Florbetaban
[18F]MK3328
Tau/Synuclein [11C]PBB3 [18F]BF-227
[11C]THK5351 [18F]Flortaucipir ([18F]AV-1451)
[18F]THK5351
[18F]THK5317
[18F]THK5105
[18F]THK523
[18F]MK6240
[18F]RO948

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