Featured studies include only those currently recruiting participants. They are listed according to the date they were added to the ClinicalTrials.gov registry, with the most recent studies appearing first.
- Functional Relevance of Dopamine Receptors in Healthy Controls and Patients With Schizophrenia: Characterization Through [11C]NNC-112 and [18F]Fallypride Positron Emission Tomography.
Evaluation study. Background: - Some illnesses, such as schizophrenia, have effects on brain cells called dopamine receptors, which are required for normal brain function. Ages 18-90. Location in Bethesda, MD.
- Safety and Effectiveness of D-Serine in Schizophrenia.
Interventional study. This study will determine whether increasing D-serine within the body will improve negative symptoms and cognitive impairments in people with schizophrenia. Ages 18-60.
- Determining Metabolic Effects of Valproate and Antipsychotic Therapy.
Interventional study. This study will determine the metabolic processes responsible for high levels of blood glucose, metabolism disorders, and weight gain in people with schizophrenia who have been treated with antipsychotic medications in combination with valproate. Ages 18-60. Location in St. Louis, MO.
- Effects of Modafinil on Brain Function in Patients With Schizophrenia.
Interventional study. This study will evaluate whether modafinil improves cognition in patients with schizophrenia and healthy volunteers. Ages 18-50.
- Screening for Childhood-Onset Psychotic Disorders.
Evaluation study. The purpose of this study is to screen and evaluate children with psychotic disorders to establish or confirm their diagnosis and to collect data about their condition. Ages 5-99. Location in Bethesda, MD.
- Genetic Study of Schizophrenia.
Evaluation study. This large ongoing study at NIMH investigates the neurobiology of schizophrenia by identifying susceptibility genes, evaluating their impact on brain function to better understand how to treat and prevent this illness. Ages 18 and over. Location in Bethesda, MD.
- Brain Tissue Collection for Neuropathological Studies.
Evaluation study. The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders. Locations in Washington, DC; Bethesda, MD; Fairfax, VA.
- Studies of Frontal Lobe Brain Functioning in Schizophrenia.
Evaluation study. The purpose of this study is to use brain imaging technology to investigate the role of the frontal lobe of the brain in the thinking of individuals with schizophrenia and other neuropsychiatric disorders and healthy volunteers. Ages 18-90. Location in Bethesda, MD.
- Inpatient Evaluation of Adults With Schizophrenia.
Evaluation study. The purpose of this study is to understand the biologic basis of schizophrenia and to determine which symptoms are related to the illness itself and which are related to medications used to treat the illness. Ages 18 and over. Location in Bethesda, MD.
- Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers.
Evaluation study. Magnetic Resonance Imaging (MRI) unlike X-rays and CT-scans does not use radiation to create a picture. Ages 3 and over. Location in Bethesda, MD.
- Evaluating Genetic Risk Factors for Childhood-Onset Schizophrenia.
Evaluation study. A study of children and adolescents (current N=100) with very early onset by age 12 (COS) of DSM-III-R defined schizophrenia with (97-M-0126) is examining the clinical, neurobiological, early neurodevelopmental, genetic, and clinical drug response characteristics of these cases. Ages 6 and over. Location in Bethesda, MD.
- Evaluation of the Genetics of Bipolar Disorder.
Evaluation study. This study looks to identify genes that may affect a person's chances of developing bipolar disorder (BP) and related conditions. Ages 18-85. Location in Bethesda, MD.