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Transforming the understanding
and treatment of mental illnesses.

Adults

A Study of Schizophrenia and the Brain: A Six-month Inpatient Evaluation Study

Enrolling nationally from around the country

The National Institute of Mental Health in Bethesda, Maryland, invites qualifying adults who have been diagnosed with schizophrenia or schizoaffective disorder to participate in an inpatient research study at the NIH Clinical Center. In this study, researchers will be evaluating how the brain works in individuals diagnosed with schizophrenia to better understand the underlying causes of this illness.

Brain and Body Imaging Studies

Enrolling locally from the Washington, D.C. metro region

Several investigational studies are measuring proteins in the brain and  body using Positron Emission Tomography (PET) technology to better understand the biological basis of mental illness and to eventually pave the way for new treatments.

Brain and Body Responses to Stress Study

Enrolling locally from the Washington, D.C. metro region

The purpose of this research study is to better understand how the brain and body work when healthy volunteers feel anxious.

Brain and Cognition Research Study

Enrolling locally from the Washington, D.C. metro region

Researchers are enrolling healthy volunteers for an outpatient research study to learn more about how the brain works.

Brain Changes in Fear and Anxiety

Enrolling locally from the Washington, D.C. metro region

The purpose of these research studies is to better understand how the brain and body work in individuals with anxiety disorders.

Brain Changes in Fear and Anxiety Study

Enrolling locally from the Washington, D.C. metro region

The purpose of this research study is to better understand how the brain and body work when healthy volunteers feel anxious.

Brain Function Study

Enrolling nationally from around the country

This research seeks to understand how protein formation in the brain is affected in fragile X syndrome (FXS).   Researchers will measure the rate at which the brain makes proteins (protein synthesis) and may identify specific parts of the brain affected in FXS. In the future, measurement of protein synthesis in FXS may help us to develop and test new therapies.

Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers

Enrolling nationally from around the country

The purpose of this study is to understand brain development during childhood and brain changes with aging. We will look at brain changes and development in healthy adults and children. We will also look at brain changes and development in people with different developmental disorders, including sex chromosome variations.

DECIBELS: DiscovEring CortIcal BiomarkErs in Language processing in adolescents with autism spectrum disorders

Enrolling locally from the Washington, D.C. metro region

Are you a healthy young adult with no neurological, psychiatric, or general medical condition 18-25 and interested in learning more about how your brain processes language? If so, you may be eligible to participate in the pilot phase of a new research study at NIMH.

Depression and Brain Changes in Fear and Anxiety

Enrolling locally from the Washington, D.C. metro region

The purpose of this research study is to better understand how the brain and body work when a person with depression feels anxious.

Depression Evaluations for Medication and Brain Imaging Studies

Enrolling nationally from around the country

This study screens for various inpatient and outpatient studies that investigate the brain and experimental medications (such as ketamine) to quickly lift severe and hard-to-treat depressive symptoms.

Depression, Experimental ECT and Brain Imaging

Enrolling nationally from around the country

This research study is testing a new type of electroconvulsive therapy (ECT) to see if it is a safe and effective method to rapidly reduce and treat depression. With this new type of ECT we decrease the strength of the electric pulse to see if that causes less memory side effects than regular ECT.  We use brain imaging to better understand how the new treatment affects the brain and how this relates to changes in depression or memory.

Depression, Repeated Doses of Ketamine, and Neuroimaging

Enrolling nationally from around the country

The purpose of this study is to evaluate the rapid and sustained antidepressant effects of repeated doses of ketamine in the brain. We want to learn how ketamine affects areas of the brain important in regulating mood and if there are unique signatures that could help predict who may respond to the drug. Also, we want to see if repeated doses of ketamine are safe and effective in treating the symptoms of depression.

Depression, TMS, Psychotherapy and Brain Function

Enrolling nationally from around the country

This research study seeks depressed participants to test the effects of the combination of repetitive transcranial magnetic stimulation (TMS) and psychotherapy on brain function.

Generalized and Social Anxiety Disorders

Enrolling locally from the Washington, D.C. metro region

This study seeks to better understand anxiety by examining changes in emotional reaction and task performance under stress. We want to understand the way these changes are different for people suffering from anxiety or mood disorders.

Healthy Research Volunteer Study

Enrolling locally from the Washington, D.C. metro region

People in good health are invited to participate as a research study volunteer. Study participants play a vital role in biomedical research by helping scientists advance knowledge and better understand, treat, and ultimately, improve health.

The National Institute of Mental Health (NIMH) is conducting this study to create a list of healthy research volunteers who are interested in participating in additional NIMH studies.

How Cognitive Behavioral Therapy (CBT) May Change Stress Responses

Enrolling locally from the Washington, D.C. metro region

This study seeks to understand how people who struggle with anxiety respond to different stressful situations, and how Cognitive Behavioral Therapy (CBT) may change these responses.

How Does the Covid-19 Pandemic Impact Mental Health?

Enrolling nationally from around the country

The purpose of this online study is to learn about how stressors related to the COVID-19 virus impact mental health and attention over time. We hope to better understand how people from a wide range of communities adjust their own behaviors, family lives, and daily activities to best cope with uncertainty and restrictions imposed by the pandemic.

Investigating the Genetics of Bipolar Disorder in those affected and their family members

Enrolling nationally from around the country

Researchers are looking for genes that may affect a person's chances of developing bipolar disorder. You can participate in this research study if you are over 18, have a bipolar diagnosis, or have a family member with bipolar disorder.

Memories and How the Brain Works

Enrolling locally from the Washington, D.C. metro region

Researchers are enrolling healthy volunteers for an outpatient research study to learn about the brain. A part of the study evaluates how the brain activates and represents memories. Participants will watch videos created in the “1 Second Everyday App” during a brain scan (MRI) and again during a MEG (magnetoencephalography) scan.

Menopause and Mood

Enrolling locally from the Washington, D.C. metro region

Researchers are working to understand depression related to the menopause transition. This placebo controlled research study will test whether an experimental medication, Lily compound LYS500307, can prevent depression that may occur after suddenly stopping Estrogen Therapy (ET). This drug acts like estrogen, but has a more limited range of effects.

NIMH Family Study of Health and Behavior

Enrolling locally from the Washington, D.C. metro region

The major goal of this study is to examine how mood disorders, anxiety disorders and migraine run in families. We study both genetic and environmental factors that may contribute to these conditions.

Perimenopause: An Observational Study

Enrolling locally from the Washington, D.C. metro region

This is an observational study for perimenopausal depression in women between the ages of 40 and 60. The purpose of this study is to investigate mood and behavioral changes in the time period surrounding and including menopause.

PMS Evaluation Study

Enrolling locally from the Washington, D.C. metro region

The purpose of this study is to identify and describe the symptoms of premenstrual syndrome (PMS).Women between the ages of 18 and 50 who experience PMS symptoms will be asked to complete clinical interviews, self-rating scales, and evaluations of mood. Your participation in this study will help researchers determine if you are eligible to participate in additional studies exploring the causes of, and treatment for PMS.

PMS: Studying the Possible Causes

Enrolling locally from the Washington, D.C. metro region

If you are a woman between 18 and 50 who experiences premenstrual syndrome (PMS), you may be eligible to help researchers investigate what causes it. This study explores possible causes of PMS by using a medication to stop the menstrual cycle temporarily. After the menstrual cycle is stopped, researchers will add back, in sequence, estrogen, and progesterone. The purpose of this study is to examine the influence of estrogen and progesterone on mood and behavior in women with PMS.

Predictability and Aversive Expectancies in Anxiety Disorders

Enrolling locally from the Washington, D.C. metro region

This study seeks to understand how people who struggle with anxiety respond to different stressful situations. Basic research has identified biological processes that play a key role in fear and anxiety. The present study examines such processes across people with varying levels of anxiety.

Still Depressed? NIH Research Study is Testing a New Antidepressant

Enrolling nationally from around the country

Antidepressant drugs can take weeks or months to work. They also do not work in up to 30% of people with depression. Researchers are studying new treatments. This research study is testing an experimental drug, TS-161, to see if it helps improve depression symptoms.

Study of the Brain, Thinking and Memory

Enrolling locally from the Washington, D.C. metro region

This part of the facial recognition study is enrolling healthy adults without psychiatric conditions, between the ages of 18 and 35, who are in good medical health, and have a bad memory for faces. The overall purpose of the study is to learn about the brain, thinking and memory in people with and without autism spectrum disorders.

Suicide and the Brain

Enrolling nationally from around the country

National Institute of Mental Health (NIMH) researchers seek adults 18 to 70, who have a history of attempted suicide but are not currently suicidal, for a study of suicide and brain function. Participation includes up to seven days as an inpatient at the NIH Clinical Center in Bethesda, Maryland. Procedures include blood tests, medical evaluations, brain imaging, sleep studies and psychiatric interviews. Participants do not need to stop their current medications. Compensation and transportation are provided. Pregnant women and individuals with serious medical conditions are not eligible.

The Impact of COVID-19 Pandemic on Anxiety and Motivation

Enrolling nationally from around the country

Researchers hope to better understand changes in emotional reactions and assess motivation in people during this stressful pandemic. We hope to understand the way these changes are different for people suffering from anxiety or mood disorders, and people who do not.

The NIMH Genetic Study of Schizophrenia

Enrolling nationally from around the country

If you or someone in your family is 18 years old or older and has been diagnosed with schizophrenia or schizoaffective disorder (depressed type), you may be able to participate in a genetic study that looks for genes in families. In order for family members to participate, the person with schizophrenia must be willing and able to participate. Eligible family members participate in an interview and contribute a sample of blood for genetic analysis. If you have schizophrenia, and if possible, your sibling, you may qualify to participate in this study. There is no change in medication involved.

Thinking and Memory Problems in People With HIV

Enrolling locally from the Washington, D.C. metro region

This research study seeks to understand how the HIV infection affects the brain, moods, memory, thinking and concentration. Researchers will evaluate the relationship among brain inflammation, protein function and MND; and how HIV infection may cause problems with blood vessel function and contribute to thinking and mood disorders, such as early dementia and depression.

TMS and Brain Function

Enrolling locally from the Washington, D.C. metro region

This research study seeks healthy adult participants to explore how transcranial magnetic stimulation (TMS) affects the brain. TMS is a non-invasive method which uses a magnet placed outside the head to stimulate precise locations inside the brain.

Understanding How Ketamine Affects Brain Chemistry

Enrolling nationally from around the country

The purpose of this study is to evaluate how a dose of ketamine affects brain chemistry, and how it alleviates depression symptoms so quickly. Ketamine is a general anesthetic medication used to put people to sleep for surgery.

Understanding the brain, mood, memory, and thinking

Enrolling locally from the Washington, D.C. metro region

This research study seeks to learn about the brain, moods, memory, thinking and concentration in healthy adults and compare them to those who have HIV infections.

Women with a History of Postpartum Depression: The Effects of Hormones in Postpartum Mood Disorders

Enrolling locally from the Washington, D.C. metro region

If you have ever suffered from postpartum depression (PPD) following childbirth, we would like you to call for information about participation in our study. The study is designed to determine if your PPD was caused by hormonal changes during or after pregnancy. This study will replicate a hormonal state of pregnancy and the 6-week period following delivery. Mood symptoms and hormone levels will be measured throughout the study.