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NIMH Research Domain Criteria Roundtable - Data-Driven Refinement of Psychopathology: Toward Precision Diagnostics


September 28, 2022




Current approaches to understanding and treating mental disorders are largely based on longstanding diagnostic criteria that rely on patient self-report and clinician judgment. There is, however, increasing recognition that psychiatric disorders are not specific disease entities but rather broad and heterogeneous syndromes. Research toward personalized, data-driven assessment may thus inform more effective clinical decisions. This meeting addressed two fundamental needs that could serve as a foundation for identifying meaningful clinical signatures:

(1) cultivating and validating behavioral tasks for individual level clinical prediction and decision-making and

(2) establishing a data infrastructure that allows for computational exploration of multimodal data. We will bring together experts in the field to discuss these topics, and what is needed to develop individually reliable precision diagnostics.


Read the transcript.

Research Domain Criteria (RDoC)

RDoC is a research framework for investigating mental disorders. Its goal is to foster new research approaches that will lead to better diagnosis, prevention, intervention, and cures. RDoC is not meant to serve as a diagnostic guide, nor is it intended to replace current diagnostic systems. The aim is to understand the nature of mental health and illness in terms of varying degrees of dysfunction in fundamental psychological/biological systems.

Sponsored by

The NIMH RDoC Unit

More Information

View the preliminary agenda.