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Laboratory of Molecular and Cellular Neurobiology (LMCN) Laboratory of Molecular and Cellular Neurobiology (LMCN)


Bäck S, Necarsulmer J, Whitaker L, Coke L, Koivula P, Heathward E, Fortuno LV, Zhang Y, Yeh G, Baldwin H, Pickel J, Hoffman AF, Spivak C, Lupica CR, Underhill SM , Amara SG, Hope BT, Richie C, Harvey BK. (2019) Neuron-specific genome modification in the adult rat brain using CRISPR/Cas9 transgenic rats. Neuron. doi: 10.1016/j.neuron.2019.01.035.  PMID:  30792150 

Mauna JC, Harris SS, Pino JA, Edwards CM, DeChellis-Marks MR, Bassi CD, Garcia-Olivares J, Amara SG, Guajardo FG, Sotomayor-Zarate R, Terminel M, Castaneda E, Vergara M, Baust T, Thiels E, Torres GE. (2019) G protein βγ subunits play a critical role in the actions of amphetamine.  Transl Psychiatry.  doi: 10.1038/s41398-019-0387-8.  PMID:  30745563 

Underhill SM, Ingram SL, Ahmari SE, Veenstra-VanderWeele J, Amara SG. (2018) Neuronal excitatory amino acid transporter EAAT3: Emerging function in health and disease. Neurochem Int. doiMay 22. Doi: 10.1016/j.neuint.2018.05.012.  PMID: 29800605 

Skirzewski M, Karavanova I, Shamir A, Erben L, Garcia-Olivares J, Shin JH, Vullhorst D, Alvarez VA, Amara SG, Buonanno A.  (2018)  ErbB4 signaling in dopaminergic axonal projections increases extracellular dopamine levels and regulates spatial/working memory behaviors.  Mol Psychiatry.  doi: 10.1038/mp.2017.132.  PMID:  28727685 

Lohani S, Martig AK, Underhill SM, DeFrancesco A, Roberts MJ, Rinaman L, Amara SG, Moghaddam B. (2018) Burst activation of dopamine neurons produces prolonged post-burst availability of actively released dopamine. Neuropsychopharmacology. doi:10.1038/s41386-018-0088-7. PMID: 29795245 

Garcia-Olivares J, Baust T, Harris S, Hamilton P, Galli A, Amara SG, Torres GE.  (2017) Gβγ subunit activation promotes dopamine efflux through the dopamine transporter.  Mol Psychiatry.  doi: 10.1038/mp.2017.176.  PMID:  28894302 

Mortensen OV, Larsen MB, Amara SG.  (2017)  MAP Kinase Phosphatase 3 (MKP3) Preserves Norepinephrine Transporter Activity by Modulating ERK1/2 Kinase-Mediated Gene Expression.  Front Cell Neurosci.  doi: 10.3389/fncel.2017.00253.  PMID:  28878626 

Divito CB, Borowski JE, Glasgow NG, Gonzalez-Suarez AD, Torres-Salazar D, Johnson JW and Amara SG. (2017) Glial and Neuronal Glutamate Transporters Differ in the Na+ Requirements for Activation of the Substrate-Independent Anion Conductance.  Front. Mol. Neurosci.  doi: 10.3389/fnmol.2017.00150. PMID: 28611584 

Cheng MH, Torres-Salazar D, Gonzalez-Suarez AD, Amara SG and Bahar I. (2017) Substrate transport and anion permeation proceed through distinct pathways in glutamate transporters. Elife. doi: 10.7554/eLife.25850.  PMID: 28569666 

Hong WC, Yano H, Hiranita T, Chin FT, McCurdy CR, Su TP, Amara SG, Katz JL. (2017)  The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats.  J Biol Chem.  doi: 10.1074/jbc.M116.774075.  PMID:  28495886 

Li M, Underhill SM, Amara SG, Ingram SL. (2017) Amphetamine and methamphetamine increase NMDA-GluN2B synaptic currents midbrain dopamine neurons. Neuropsychopharmacology. Dec 15. doi: 10.1038/npp.2016.278. PMID: 27976681 

Cheng MH, Torres-Salazar D, Gonzalez-Suarez AD, Amara SG and Bahar IPii: e25850.Divito CB, Borowski JE, Glasgow NG, Gonzalez-Suarez AD, Torres-Salazar D, Johnson JW and Amara SG (2017) Front. Mol.10:150. PIMD: 28611584 

Gonzalez-Suarez AD, Nash AI, Garcia-Olivares J and Torres-Salazar D. (2017) Emerging Evidence for a Direct Link between EAAT-Associated Anion Channels and Neurological Disorders. J Neurosci. doi: 10.1523/JNEUROSCI.2947-16.201737(2): 241-243. PMID: 28077704 

Torres-Salazar D, Gonzalez-Suarez AD, Amara SG. (2016) Transport and channel functions in EAATs: the missing link. Channels (Austin). doi: 10.1080/19336950.2015.1119631.  PMID: 26683197 

Bjørn-Yoshimoto WE, Underhill SM. (2016) The importance of the excitatory amino acid transporter 3 (EAAT3). Neurochem Int. May 24. pii: S0197- 0186(16)30106-1. doi: 10.1016/j.neuint.2016.05.007.  PMID:  27233497 

Wheeler DS, Underhill SM, Stolz DB, Murdoch GH, Thiels E, Romero G Amara SG. (2015) Amphetamine activates Rho GTPase signaling to mediate dopamine transporter internalization and acute behavioral effects of amphetamine. Proc Natl Acad Sci USA. doi: 10.1073/pnas.1511670112.  PMID: 26553986 

Torres-Salazar D, Jiang J, Divito CB, Garcia-Olivares J and Amara SG. (2015) A Mutation in Transmembrane Domain 7 (TM7) of Excitatory Amino Acid Transporters Disrupts the Substrate-dependent Gating of the Intrinsic Anion Conductance and Drives the Channel into a Constitutively Open State. J Biol Chem.  doi: 10.1074/jbc.M115.660860.  PMID: 26203187 

Underhill SM, Wheeler DS, Amara SG. (2015) Differential regulation of two isoforms of the glial glutamate transporter EAAT2 by DLG1 and CAMKII. J Neurosci.  doi: 10.1523/JNEUROSCI.4365-14.2015. PMID: 25834051 

Watts SD, Torres-Salazar D, Divito CB, Amara SG. (2014) Cysteine Transport through Excitatory Amino Acid Transporter 3 (EAAT3). PLoS One.  doi: 10.1371/journal.pone.0109245.  PMID: 25275463 

Underhill SM, Wheeler DS, Li M, Watts SD, Ingram SL, Amara SG. (2014) Amphetamine modulates excitatory neurotransmission through endocytosis of the glutamate transporter EAAT3 in dopamine neurons. Neuron. doi: 10.1016/j.neuron.2014.05.043. PMID: 25033183 

Divito CB, Underhill SM. (2014) Excitatory amino acid transporters: Roles in glutamatergic neurotransmission. Neurochem Int.  doi: 10.1016/j.neuint.2013.12.008. PMID: 24418112 

Garcia-Olivares J, Torres-Salazar D, Owens WA, Baust T, Siderovski DP, Amara SG, Zhu J, Daws LC, Torres GE. (2013) Inhibition of Dopamine transporters activity by G protein Bγ subunits PLoS One.  doi: 10.1371/journal.pone.0059788.  PMID: 23555781 

Hong WC, and Amara SG. (2013) Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons.  J. Biol Chem.  doi: 10.1074/jbc.M110.150565.  PMID: 20688912