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Molecular Imaging Branch (MIB)

2012 Publications

Full Refereed Papers

1. RISS P.J., LU, S.Y., TELU S., AIGBIRHIO, F. I., PIKE V.W. Cu(I)-catalyzed 11C-carboxylation of boronic acid esters: a rapid and convenient entry to 11C-labeled carboxylic acids, esters and amides. Angew. Chem. Intl. Ed. 2012, 51, 2698-2702. [doi: 10.1002/anie.201107263. PMID:22308017] . (Highlighted in Synfacts, 2012, 8, 667).

2. SIMÉON F.G., LIOW J.-S., ZHANG Y., HONG J., GLADDING R.L., ZOGHBI S.S., INNIS R.B., PIKE V.W. Synthesis and characterization in monkey of [11C]SP203 as a radioligand for imaging brain metabotropic glutamate 5 receptors. Eur. J. Nucl. Med. Mol. Imaging 2012, 39, 1949-1958. [doi: 10.1007/s00259-012-2205-x. PMID:22885775] .

3. CHUN J.-H., PIKE V. W. Regiospecific syntheses of functionalized diaryliodonium tosylates via [hydroxy(tosyloxy)iodo]arenes generated in situ from (diacetoxyiodo)arenes. J. Org. Chem. 2012, 77, 1931-1938. [doi: 10.1021/jo202517v. PMID:22276914] .

4. BAO X., LU S.Y., LIOW J.-S., ZOGHBI S.S., JENKO K.J., CLARK D.T., GLADDING R.L., INNIS R.B., PIKE V.W. Radiosynthesis and evaluation of an 18F-labeled PET radioligand for brain histamine subtype-3 receptors based on a non-imidazole 2-aminoethylbenzofuran chemotype. J. Med. Chem. 2012, 55, 2406-2415. [doi: 10.1021/jm201690h. PMID:22313227] .

5. CHUN J.-H., PIKE V.W. Selective syntheses of no-carrier-added 2- and 3-[18F]fluorohalopyridines through the radiofluorination of halopyridinyl(4’-methoxyphenyl)iodonium tosylates. Chem. Commun. 2012, 9921-9923. [doi: 10.1039/c2cc35005j. PMID:22932709] .

6. LEE Y-S., SIMÉON F.G., BRIARD E., PIKE V.W. Solution structures of the prototypical 18 kDa translocator protein ligand, PK 11195, elucidated with 1H/13C-NMR spectroscopy and quantum mechanics. ACS Chem. Neurosci. 2012, 3, 325-335. [doi: 10.1021/cn3000108. PMID:22860199] .

7. SHRESTHA S., HIRVONEN J., HINES C.S., HENTER I., SVENNINGSSON P., PIKE V.W., INNIS R.B. Serotonin-1A receptors in major depression quantified using PET: controversies, confounds, and recommendations. NeuroImage 2012, 59, 3243-3251. [doi: 10.1016/j.neuroimage.2011.11.029. PMID:22155042] .

8. OGHBI S.S., ANDERSON K.B., JENKO K.J., LUCKENBAUGH D.A., INNIS R.B., PIKE V.W. On quantitative relationships between drug-like compound lipophilicity and plasma free fraction in monkey and human. J. Pharmaceut. Sci. 2012, 101, 1028-1039. [doi: 10.1002/jps.22822. PMID:22170327] .

9. CAI L., XU R., GUO X., PIKE V.W. Rapid room-temperature 11C-methylation of arylamines with [11C]methyl iodide promoted by solid inorganic bases in DMF. Eur. J. Org. Chem. 2012, 1303-1310. [doi: 10.1002/ejoc.201101499].

10. LOHITH T.G., ZOGHBI S.S., MORSE C.L., ARANETA M.F., BARTH V.N., GOEBL N.A., TAUSCHER J.T., PIKE V.W., INNIS R.B., FUJITA M. Brain and whole-body imaging of nociceptin/orphanin FQ peptide receptor in humans using the PET ligand 11C-NOP-1A. J. Nucl. Med. 2012, 53, 385–392. [doi: 10.2967/jnumed.111.097162. PMID:22312136] .

11. HIRVONEN J., GOODWIN R.S., LI C.-T., TERRY G.E., ZOGHBI S.S., MORSE C., PIKE V.W., VOLKOW N.D., HUESTIS M.A., INNIS R.B. Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers. Mol. Psychiatry 2012, 17, 642-649. [doi: 10.1038/mp.2011.82. PMID:h21747398] .

12. HIRVONEN J., KREISL W.C., FUJITA M., DUSTIN I., KHAN O., APPEL S., ZHANG Y., MORSE C., PIKE V.W., INNIS R.B., THEODORE W.H. Increased in vivo expression of an inflammatory marker in temporal lobe epilepsy. J. Nucl. Med. 2012, 53, 234-240. [doi: 10.2967/jnumed.111.091694. PMID:22238156] .

13. KIMURA Y., SIMÉON F.G., ZOGHBI S.S., ZHANG Y., HATAZAWA J., PIKE V.W., INNIS R.B., FUJITA M. Quantification of metabotropic glutamate subtype 5 receptors in brain by an equilibrium method using 18F-SP203. NeuroImage, 2012, 59, 2124-2130. [doi: 10.1016/j.neuroimage.2011.10.028. PMID:22032949] .

14. FARKAS S., NAGY K., PALKOVITS M., KOVÁCS G.G., JIA Z., DONOHUE S., PIKE V.W., HALLDIN C., MÁTHÉ D., HARKANY T., GULYÁS B., CSIBA L. [125I]SD-7015 reveals fine modalities of CB1 cannabinoid receptor density in the prefrontal cortex during progression of Alzheimer’s disease. Neurochem. Intl. 2012, 60, 286-291. [doi: 10.1016/j.neuint.2011.11.004. PMID:22222721] .

15. FARKAS S., NAGY K., JIA Z., HARKÁNY T., PALKOVITS M., DONOHUE S.R., PIKE V.W., HALLDIN C., MÁTHÉ D., CSIBA L., GULYÁS B. The decrease of dopamine D2/D3 receptor densities in the putamen and nucleus caudatus goes parallel with maintained levels of CB1 cannabinoid receptors in Parkinson’s disease: a preliminary autoradiographic study with the selective dopamine D2/D3 antagonist [3H]raclopride and the novel CB1 inverse agonist [125I]SD7015. Brain Res. Bull. 2012, 87, 504-510. [doi: 10.1016/j.brainresbull.2012.02.012. PMID:22421165] .

16. CHUN J-H., PIKE V.W. Single-step radiosyntheses of ‘18F-labeled click synthons’ from azide-functionalized diaryliodonium salts. Eur. J. Org. Chem. 2012, 4541-4547. [doi: 10.1002/ejoc.201200695].

17. FUJITA M., HINES C.S., ZOGHBI S.S., MALLINGER A.G., DICKSTEIN L.P., LIOW J.-S., ZHANG Y., PIKE V.W., DREVETS W.C., INNIS R.B., ZARATE JR. C.A. Downregulation of brain phosphodiesterase type IV measured with 11C-(R)-rolipram PET in major depressive disorder. Biol. Psychiatry 2012, 72, 548-554. [doi: 10.1016/j.biopsych.2012.04.030. PMID:22677471] .

18. BAO X., LU S., LIOW J.-S., ANDERSON K., MORSE C.L., ZOGHBI S.S., INNIS R.B., PIKE V.W. [11C]Rhodamine-123: synthesis and biodistribution in rodents. Nucl. Med. Biol. 2012, 39, 1128-1136. [doi: 10.1016/j.nucmedbio.2012.06.013. PMID:22898316] .

19. ZANOTTI-FREGONARA P., HINES C.S., ZOGHBI S.S., LIOW J.-S., ZHANG Y., PIKE V.W., DREVETS W.C., MALLINGER A.G., ZARATE JR. C.A., FUJITA M., INNIS R.B. Population-based input function and image-derived input function for [11C](R)-rolipram PET imaging: methodology, validation and application to the study of major depressive disorder. NeuroImage 2012, 63, 1532-1541. [doi: 10.1016/j.neuroimage.2012.08.007. PMID:22906792] .

20. ZANOTTI-FREGONARA P., LIOW J.-S., COMTAT C., ZOGHBI S.S., ZHANG Y., PIKE V. W., FUJITA M., INNIS R.B. Image–derived input function in PET brain studies: blood-based methods are insensitive to motion artifacts. Nucl. Med. Commun. 2012, 33, 982-989. [doi: 10.1097/MNM.0b013e328356185c. PMID:22760300] .