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Molecular Imaging Branch (MIB)

2021 Publications

Full Refereed Papers

A.J. Boyle, J. Tong, S.S. Zoghbi, V.W. Pike, R.B. Innis, N. Vasdev, Repurposing [11C]PS13 for PET imaging of cyclooxygenase-1 (COX-1) in ovarian cancer xenograft mouse models. J.Nucl. Med. (2021) 62, 655-668. DOI:10.2967/jnumed.120.249367. 

J.E. Jakobsson, S. Telu, S. Lu, S. Jana, V.W. Pike, Broad scope and high‐yield access to unsymmetrical acyclic [11C]ureas for biomedical imaging from [11C]carbonyl difluoride. Chem. Eur. J. (2021) 27, 10369-10376. DOI:10.1002/chem.202100690. 

C. Taddei, C.L. Morse, M.-J. Kim, J.S. Liow, J. Montero Santamaria, A. Zhang, L.S. Manly,P. Zanotti-Fregonara, R.L. Gladding, S.S. Zoghbi, R.B. Innis, V.W. Pike, Synthesis of [18F]PS13 and evaluation as a PET radioligand for cyclooxygenase-1 in monkey. ACS Chem. Neurosci. (2021) 12, 517–530. DOI:10.1021/acschemneuro.0c00737. 

J. Hong, S. Telu, Y. Zhang, W.H. Miller, H.U. Shetty, C.L. Morse, V.W. Pike, Translation of 11C-labelled tracer synthesis to a CGMP environment as exemplified by [11C]ER176 for PET imaging of human TSPO. Nat. Protocols (202116, 4419-4445. (Highlighted on Journal Masthead). DOI:10.1038/s41596-021-00584-4. 

J.-H. Lee, M. Veronese, J.S. Liow, C.L. Morse, J.A. Montero Santamaria, M.B. Haskali, S.S. Zoghbi, V.W. Pike, R.B. Innis, P. Zanotti-Fregonara, Region-and voxel-based quantification in human brain of [18F]LSN3316612, a radioligand for O-GlcNAcase. EJNMMI Res. (2021) 11, Article ID 35. DOI:10.1186/s13550-021-00780-z. 

X. Yan, S. Telu, R.M. Dick, J.S. Liow, P. Zanotti-Fregonara, C.L. Morse, L.S. Manly, R.L. Gladding, S. Shrestha, W. Lerchner, Y. Nagai, T. Minamimoto, S.S. Zoghbi, R.B. Innis, V.W. Pike, B.J. Richmond, M.A.G. Eldridge, [11C]Deschloroclozapine is an improved PET radioligand for quantifying a human muscarinic DREADD expressed in monkey brain. J. Cereb. Blood Flow Metab. (2021) 41, 2571-2582. DOI:10.1177/0271678x211007949. 

F.G. Siméon, J.-H. Lee, C.L. Morse, I. Stukes, S.S. Zoghbi, L.S. Manly, J.S. Liow, R.L. Gladding, R.M. Dick, X. Yan, S. Taliani, B. Costa, C. Martini, F. Da Settimo, S. Castellano, R.B. Innis, V.W. Pike, Synthesis and screening in mice of fluorine-containing PET radioligands or TSPO: discovery of a promising 18F-labeled ligand. J. Med. Chem. (2021) 64, 16731-16745. DOI: 10.1021/acs.jmedchem.1c01562.