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Molecular Imaging Branch (MIB)

2.1 Radiosynthesis Automation

2 Research Method Development

2.1 Radiosynthesis automation

Two of our six hot-cells are equipped with Synthia radiosynthesis devices, which were custom-built for PRSS by Synthia Lab AB, now Uppsala IMANET a subsidiary of GE Healthcare. These devices are PC-controlled and semi-robotic. They are designed principally to perform 11C-chemistry with a variety of labeling agents. These include [11C]carbon monoxide for reactions in a microautoclave,1 an important emerging area of 11C-radiochemistry. Synthia was adapted in-house to perform 18F-chemistry. Synthia was also coupled to a microwave reactor to expand its capability further.

Two other hot-cells are equipped with TRACERLab FXF-N boxes (formerly Nuclear Interface, now GE) for radiochemistry with [18F]fluoride ion, one of which is used to produce [18F]fallypride (6). The other box was successfully adapted by addition of a second automated reactor for two-stage radiochemistry. This second reactor was constructed within NIMH according to our design and is used regularly to produce [18F]SPA-RQ (7).2 Both boxes are used for experimental radiotracer production.

The two remaining hot-cells are equipped with a Micro-Lab MeI system and a FXc carbon-11 chemistry system (both from GE). The Micro-lab system is linked to a single loop methylation device3 (Bioscan). This apparatus is the main facility for producing experimental and literature 11C-labeled tracers from [11C]methyl iodide or [11C]methyl triflate.