2.2 Labeling Agents

2 Research Method Development

2.2 Labeling agents

From its inception, the PRSS began to build its capability for producing important labeling agents. Presently available agents include [¹¹C]carbon dioxide, [¹¹C]carbon monoxide, [¹¹C]methyl iodide, [¹¹C]methyl triflate, [¹¹C]carboxylic acid chlorides, [¹⁸F]fluoride ion, [¹⁸F]fluoromethyl bromide⁴, [¹⁸F]2-fluoroethyl tosylate⁴ and [¹⁸F]fluoropropyl tosylate⁴. Routes to these labeling agents with their principal applications in preparing radiotracers for our program are shown in Figure 1. The preparation of new labeling agents was also accomplished, including [¹¹C]methanesulfonyl chloride⁵ and various [¹⁸F]fluoroethyl sulfonates,⁶ which expand the breadth of our radiochemistry capability.