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Systems Neuroscience Imaging Resource Systems Neuroscience Imaging Resource


Please adapt the following text as appropriate when acknowledging the use of SNIR equipment in publications:

“Acknowledgments: We would like to acknowledge use of National Institute of Mental Health Intramural Program (or NIMH IRP) Systems Neuroscience Imaging Resource equipment and/or software. We appreciate the training and support from (Jonathan Kuo, Sarah Williams Avram, Vitaly Boyko, Snehashis Roy, Ted Usdin [as appropriate]).”

Publications Using SNIR Resources

  1. Inácio AR, Lam KC, Zhao Y, Pereira F, Gerfen CR, Lee S. Distinct brain-wide presynaptic networks underlie the functional identity of individual cortical neurons. BioRxiv. 2023 May 25;
  2. Lee SH, Cilz NI, Avram SKW, Cymerblit-Sabba A, Song J, Courey K, et al. Stimulation of median raphe terminals in dorsal CA2 reduces social investigation in male mice specifically investigating social stimulus of ovariectomized female mice. BioRxiv. 2023 Sep 1;
  3. Enriquez-Traba J, Yarur-Castillo HE, Flores RJ, Weil T, Roy S, Usdin TB, et al. Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors. BioRxiv. 2023 Jun 28;
  4. Yarur HE, Casello SM, Tsai VS, Enriquez-Traba J, Kore R, Wang H, et al. Dynorphin / kappa-opioid receptor regulation of excitation-inhibition balance toggles afferent control of prefrontal cortical circuits in a pathway-specific manner. Mol Psychiatry. 2023 Aug 29;
  5. Akitake B, Douglas HM, LaFosse PK, Beiran M, Deveau CE, O’Rawe J, et al. Amplified cortical neural responses as animals learn to use novel activity patterns. Curr Biol. 2023 Jun 5;33(11):2163-2174.e4.
  6. Gao C, Gohel CA, Leng Y, Ma J, Goldman D, Levine AJ, et al. Molecular and spatial profiling of the paraventricular nucleus of the thalamus. eLife. 2023 Mar 3;12.
  7. Bakalar D, Gavrilova O, Jiang SZ, Zhang H-Y, Roy S, Williams SK, et al. Constitutive and conditional deletion reveals distinct phenotypes driven by developmental versus neurotransmitter actions of the neuropeptide PACAP. J Neuroendocrinol. 2023 May 2;e13286.
  8. Schoenfeld TJ, Rhee D, Smith JA, Padmanaban V, Brockett AT, Jacobs HN, et al. Rewarded Maze Training Increases Approach Behavior in Rats Through Neurogenesis-Dependent Growth of Ventral Hippocampus–Prelimbic Circuits. Biological Psychiatry Global Open Science. 2023 Apr;
  9. Messanvi KF, Berkun K, Perkins A, Chudasama Y. Parallel pathways provide hippocampal spatial information to prefrontal cortex. J Neurosci. 2023 Jan 4;43(1):68–81.
  10. Qi J, Ye C, Naskar S, Inácio AR, Lee S. Posteromedial thalamic nucleus activity significantly contributes to perceptual discrimination. PLoS Biol. 2022 Nov 28;20(11):e3001896.
  11. Inagaki HK, Chen S, Ridder MC, Sah P, Li N, Yang Z, et al. A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement. Cell. 2022 Mar 17;185(6):1065-1081.e23.
  12. Li Y, Su Y, Guo M, Han X, Liu J, Vishwasrao HD, et al. Incorporating the image formation process into deep learning improves network performance. Nat Methods. 2022 Nov;19(11):1427–37.
  13. Elliott AD, Berndt A, Houpert M, Roy S, Scott RL, Chow CC, et al. Pupal behavior emerges from unstructured muscle activity in response to neuromodulation in Drosophila. eLife. 2021 Jul 8;10.
  14. Ma J, du Hoffmann J, Kindel M, Beas BS, Chudasama Y, Penzo MA. Divergent projections of the paraventricular nucleus of the thalamus mediate the selection of passive and active defensive behaviors. Nat Neurosci. 2021 Oct;24(10):1429–40.
  15. Helseth AR, Hernandez-Martinez R, Hall VL, Oliver ML, Turner BD, Caffall ZF, et al. Cholinergic neurons constitutively engage the ISR for dopamine modulation and skill learning in mice. Science. 2021 Apr 23;372(6540).
  16. Naskar S, Qi J, Pereira F, Gerfen CR, Lee S. Cell-type-specific recruitment of GABAergic interneurons in the primary somatosensory cortex by long-range inputs. Cell Rep. 2021 Feb 23;34(8):108774.
  17. Panja D, Li Y, Ward ME, Li Z. miR-936 is Increased in Schizophrenia and Inhibits Neural Development and AMPA Receptor-Mediated Synaptic Transmission. Schizophr Bull. 2021 Oct 21;47(6):1795–805.
  18. Cymerblit-Sabba A, Smith AS, Williams Avram SK, Stackmann M, Korgan AC, Tickerhoof MC, et al. Inducing partner preference in mice by chemogenetic stimulation of CA2 hippocampal subfield. Front Mol Neurosci. 2020 Apr 23;13:61.
  19. Sofia Beas B, Gu X, Leng Y, Koita O, Rodriguez-Gonzalez S, Kindel M, et al. A ventrolateral medulla-midline thalamic circuit for hypoglycemic feeding. Nat Commun. 2020 Dec 4;11(1):6218.
  20. Nordman J, Li Z. The Dorsal Raphe Regulates the Duration of Attack through the Medial Orbitofrontal Cortex and Medial Amygdala. eNeuro. 2020 Oct 26;7(5).
  21. Lehmann ML, Poffenberger CN, Elkahloun AG, Herkenham M. Analysis of cerebrovascular dysfunction caused by chronic social defeat in mice. Brain Behav Immun. 2020 Aug;88:735–47.
  22. Shrestha S, Kim M-J, Eldridge M, Lehmann ML, Frankland M, Liow J-S, et al. PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study. J Neuroinflammation. 2020 May 2;17(1):140.
  23. Shen H, Zhu H, Panja D, Gu Q, Li Z. Autophagy controls the induction and developmental decline of NMDAR-LTD through endocytic recycling. Nat Commun. 2020 Jun 12;11(1):2979.
  24. Nordman JC, Ma X, Gu Q, Potegal M, Li H, Kravitz AV, et al. Potentiation of Divergent Medial Amygdala Pathways Drives Experience-Dependent Aggression Escalation. J Neurosci. 2020 Jun 17;40(25):4858–80.
  25. Nordman J, Ma X, Li Z. Traumatic Stress Induces Prolonged Aggression Increase through Synaptic Potentiation in the Medial Amygdala Circuits. eNeuro. 2020 Jul 23;7(4).
  26. Sanzeni A, Akitake B, Goldbach HC, Leedy CE, Brunel N, Histed MH. Inhibition stabilization is a widespread property of cortical networks. eLife. 2020 Jun 29;9.
  27. Petrus E, Dembling S, Usdin T, Isaac JTR, Koretsky AP. Circuit-Specific Plasticity of Callosal Inputs Underlies Cortical Takeover. J Neurosci. 2020 Sep 30;40(40):7714–23.
  28. Gao C, Leng Y, Ma J, Rooke V, Rodriguez-Gonzalez S, Ramakrishnan C, et al. Two genetically, anatomically and functionally distinct cell types segregate across anteroposterior axis of paraventricular thalamus. Nat Neurosci. 2020 Feb;23(2):217–28.
  29. Guo M, Li Y, Su Y, Lambert T, Nogare DD, Moyle MW, et al. Rapid image deconvolution and multiview fusion for optical microscopy. Nat Biotechnol. 2020 Nov;38(11):1337–46.
  30. Young WS, Song J. Characterization of oxytocin receptor expression within various neuronal populations of the mouse dorsal hippocampus. Front Mol Neurosci. 2020 Mar 18;13:40.
  31. Williams Avram SK, Lee H-J, Fastman J, Cymerblit-Sabba A, Smith A, Vincent M, et al. NMDA Receptor in Vasopressin 1b Neurons Is Not Required for Short-Term Social Memory, Object Memory or Aggression. Front Behav Neurosci. 2019 Nov 8;13:218.
  32. Lehmann ML, Weigel TK, Poffenberger CN, Herkenham M. The behavioral sequelae of social defeat require microglia and are driven by oxidative stress in mice. J Neurosci. 2019 Jul 10;39(28):5594–605.
  33. Lehmann ML, Weigel TK, Cooper HA, Elkahloun AG, Kigar SL, Herkenham M. Decoding microglia responses to psychosocial stress reveals blood-brain barrier breakdown that may drive stress susceptibility. Sci Rep. 2018 Jul 26;8(1):11240.
  34. Beas BS, Wright BJ, Skirzewski M, Leng Y, Hyun JH, Koita O, et al. The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism. Nat Neurosci. 2018 Jul;21(7):963–73.