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NIMH RDoC Publications

Browse publications about the Research Domain Criteria (RDoC), an NIMH initiative. RDoC is a research framework designed for studying the full range of human behavior from normal to abnormal based on biology, behavior, and context.

In Press

Morris, S. E., Pacheco, J., & Sanislow, C. A. (in press). Applying Research Domain Criteria (RDoC) Dimensions to Psychosis. In C. Tamminga, E. I. Ivleva, U. Reininghaus, & J. van Os (Eds.) Psychotic Disorders: Comprehensive Conceptualization and Treatments. Oxford University Press, Oxford, UK.

Sanislow, C. A., Morris, S. E., Pacheco, J., & Cuthbert, B. N. (in press). The National Institute of Mental Health Research Domain Criteria: An Alternative Framework to Guide Psychopathology Research. In J. R. Geddes, N. C. Andreasen, and G. M. Goodwin (Eds). The New Oxford Textbook of Psychiatry (3rd Edition). Oxford University Press, Oxford, UK.


Sanislow, C. A., Ferrante, M., Pacheco, J., & Morris, S. E. (2019). Advancing translational research with the NIMH Research Domain Criteria and Computational Methods. Neuron, 101, 779-782 PMID: 30844398 


National Advisory Mental Health Council Workgroup on Changes to the Research Domain Criteria Matrix (2018). RDoC Changes to the Matrix (CMAT) Workgroup Update: Addition of the Sensorimotor Domain. Bethesda, MD.

National Advisory Mental Health Council Workgroup on Changes to the Research Domain Criteria Matrix (2018). RDoC Changes to the Matrix (CMAT) Workgroup Update: Proposed Positive Valence Domain Revisions. Bethesda, MD.


Clark LA, Cuthbert B, Lewis-Fernández R, Narrow WE, Reed GM. Three Approaches to Understanding and Classifying Mental Disorder: ICD-11, DSM-5, and the National Institute of Mental Health’s Research Domain Criteria (RDoC). Psychological Science in the Public Interest. 2017 Sep;18(2):72-145. PMID: 29211974 

Garvey MA, Cuthbert BN. Developing a Motor Systems Domain for the NIMH RDoC Program. Schizophr Bull. 2017 Sep 1;43(5):935-936. doi: 10.1093/schbul/sbx095. PMID: 28911051 

Vaidyanathan U, Pacheco J. Research Domain Criteria Constructs: Integrative reviews and empirical perspectives. J Affect Disord. 2017 Jul;216:1-2. doi: 10.1016/j.jad.2017.05.028. PMID: 28610708 


Morris SE, Vaidyanathan U, Cuthbert BN. Changing the diagnostic concept of schizophrenia: the NIMH research domain criteria initiative. In The Neuropsychopathology of Schizophrenia 2016 (pp. 225-252). Springer International Publishing. PMID: 27627829 

National Advisory Mental Health Council Workgroup on Tasks and Measures for Research Domain Criteria (2016). Behavioral Assessment Methods for RDoC Constructs. Bethesda, MD.

Sanislow CA. Connecting psychopathology meta-structure and mechanisms. J Abnorm Psychol. 2016 Nov;125(8):1158-1165. PMID: 27819475 

Sanislow CA. Updating the Research Domain Criteria. World Psychiatry. 2016 Oct;15(3):222-223. doi: 10.1002/wps.20374. PMID: 27717261 

Cuthbert BN. The NIMH Research Domain Criteria Project: Research Domain Criteria and global mental health. In M. State, BL. Miller, & T. Lehner (Eds). Genomics, Circuits, and Pathways in Clinical Neuropsychiatry. Cambridge, MA: Academic Press; 2016 Jun 7. (pp. 397 – 410).

Kozak MJ, Cuthbert BN. The NIMH Research Domain Criteria Initiative: Background, issues, and pragmatics. Psychophysiology. 2016 Mar;53(3):286-97. doi:10.1111/psyp.12518. PMID: 26877115 

Garvey M, Avenevoli S, Anderson K. The National Institute of Mental Health Research Domain Criteria and Clinical Research in Child and Adolescent Psychiatry. J Am Acad Child Adolesc Psychiatry. 2016 Feb;55(2):93-8. doi: 10.1016/j.jaac.2015.11.002. PMID: 26802775 

Goldstein AB, Morris SE. Reconceptualizing Prevention: Commentary on “Conducting Psychopathology Prevention Research in the RDoC Era”. Clinical Psychology: Science and Practice. Epub: 2016 Feb 16. DOI: 10.1111/cpsp.12143


Morris SE, Vaidyanathan U, Cuthbert BN. Psychophysiological science and the research domain criteria: A commentary. Int J Psychophysiol. 2015 Nov;98(2 Pt 2):378-80. doi: 10.1016/j.ijpsycho.2015.11.002. PMID: 26546860 

Vaidyanathan U, Vrieze SI, Iacono, WG. The power of theory, research design, and transdisciplinary integration in moving psychopathology forward. Psychol Inq. 2015; 26(3): 209-230. doi:10.1080/1047840X.2015.1015367

Cuthbert BN. Research Domain Criteria: Toward future psychiatric nosologies. Dialogues Clin Neurosci. 2015 Mar;17(1):89-97. PMID: 25987867 

Sanislow CA, Quinn KJ, Sypher I. NIMH Research Domain Criteria (RDoC) (2015). In (R. L. Cautin & S. O. Lilienfeld, Eds.) The Encyclopedia of Clinical Psychology. Hoboken, NJ: Wiley-Blackwell. 2015.


Cuthbert BN. Translating intermediate phenotypes to psychopathology: the NIMH Research Domain Criteria. Psychophysiology. 2014 Dec;51(12):1205-6. doi: 10.1111/psyp.12342. PMID: 25387702  

Ford JM, Morris SE, Hoffman RE, Sommer I, Waters F, McCarthy-Jones S, Thoma RJ, Turner JA, Keedy SK, Badcock JC, Cuthbert BN. Studying Hallucinations Within the NIMH RDoC Framework. Schizophr Bull. 2014 Jul;40 (Suppl 4):S295-304. PMID: 4141312 

Cuthbert BN. Response to Lilienfield, Behaviour Research and Therapy. Behav Res Ther. 2014 Nov;62:140-2. PMID: 25294624 

Casey BJ, Oliveri ME, Insel T. A neurodevelopmental perspective on the Research Domain Criteria (RDoC) framework. Biol Psychiatry. 2014 Sep 1; 76(5): 350-3. PMID: 25103538 

Etkin A, Cuthbert B. Beyond the DSM: Development of a transdiagnostic psychiatric neuroscience course. Acad Psychiatry. 2014 Apr; 38(2): 145-50. PMID: 24493358  

Cuthbert BN. Research domain criteria: Toward future psychiatric nosology. Asian Journal of Psychiatry. 2014; 7:4-5.

Cuthbert BN. NIMH RDoC Workgroup. The RDoC framework: Continuing commentary. World Psychiatry. 2014 Jun; 13(2): 196-7. PMCID: PMC4102294  

Cuthbert BN. The RDoC framework: Facilitating transition from ICD/DSM to approaches that integrate neuroscience and psychopathology. World Psychiatry. 2014 Feb; 13(1): 28-35. PMCID: PMC2918011  

Simmons JM, Quinn KJ. The NIMH Research Domain Criteria (RDoC) Project: Implications for genetics research. Mamm Genome. 2014 Feb;25(1-2): 23-31.PMID: 24085332  

Morris SE, Rumsey JM, Cuthbert BN. Rethinking mental disorders: the role of learning and brain plasticity. Restor Neurol Neurosci. 2014;32(1): 5-23. PMID: 23902986  


Cuthbert BN, Kozak MJ. Constructing constructs for psychopathology: The NIMH research domain criteria. J Abnorm Psychol. 2013 Aug;122(3):928-37. PMID: 24016027  

Cuthbert BN, Insel TR. Toward the future of psychiatric diagnosis: the seven pillars of RDoC. BMC medicine. 2013;11:126. PMCID: PMC3653747  


Morris SE, Cuthbert BN. Research Domain Criteria: Cognitive systems, neural circuits, and dimensions of behavior. Dialogues Clin Neurosci. 2012 Mar;14(1):29-37. PMCID: PMC3341647  


Cuthbert B, Insel T. The data of diagnosis: New approaches to psychiatric classification. Psychiatry. 2010 Winter;73(4):311-314. PMID: 21198381  

Sanislow CA, Pine DS, Quinn KJ, Kozak MJ, Garvey MA, Heinssen RK, Wang PS, Cuthbert BN. Developing constructs for psychopathology research: Research domain criteria. J Abnorm Psychol. 2010 Nov;119(4):631-9. PMID: 20939653  

Cuthbert BN, Insel TR. Toward new approaches to psychotic disorders: The NIMH Research Domain Criteria project. Schizophr Bull. 2010 Nov;36(6):1061-2. Epub 2010 Oct 7. PMCID: PMC2963043  

Cuthbert BN, Insel TR. New directions in diagnosis: Research domain criteria and global mental health. In E. Sorel (Ed.), 21st century global mental health. Burlington, MA: Jones & Bartlett. 2010. (pp. 55-70).

Insel T, Cuthbert B, Garvey M, Heinssen R, Pine DS, Quinn K, Sanislow C, Wang P. Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders. Am J Psychiatry. 2010 Jul;167(7):748-51. PMID: 20595427  

Cuthbert, BN & Insel, TR. Classification issues in women's mental health: Clinical utility and etiological mechanisms. Arch Womens Ment Health. 2010 Feb;13(1):57-9. PMID: 20058041  


Insel, TR & Cuthbert, BN. Endophenotypes: Bridging genomic complexity and disorder heterogeneity. Biological Psychiatry. 2009 Dec 1;66(11), 988-9. PMID: 19900610