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and treatment of mental illnesses.

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Multimodal Neurotherapeutics Program

Overview

This program supports research that seeks to develop and refine multimodal or combination non-invasive neuromodulation therapies; identify and validate targets for novel interventions using such modalities; identify functional biomarkers associated with novel targets; and further elucidate brain-behavior relationships. The overall goal is to advance neurotherapeutics for major mental disorders and clinical dimensions of psychopathology (RDoC) through a “non-siloed,” personalized medicine approach with an emphasis on the synergistic effects of combined approaches.

Areas of Emphasis

  • Early-phase (Proof of Mechanism) studies to test and analyze novel multimodal interventions and their network and/or clinical targets
  • Proof of Concept clinical trials to demonstrate target engagement, safety, and early signs of efficacy of promising multimodal interventions
  • Studies to evaluate potential biomarkers, including engagement of relevant cognitive-behavioral (e.g., emotional reactivity, neurocognitive performance) and brain-related components, using fMRI, electrophysiology, etc. to demonstrate target engagement and related biological, behavioral, or cognitive effects
  • Treatment studies integrating biomarkers with traditional endpoints to validate the utility of putative surrogate markers of treatment response
  • Studies to predict treatment response and facilitate individualized treatment strategies
  • Studies of intervention development that seek to mitigate adverse effects of multimodal interventions
  • Studies to identify mechanisms of multimodal effects and their association with aspects of behavior or cognition

Contact

Lizzy Ankudowich, Ph.D.
Program Chief
6001 Executive Boulevard
301-480-8187, lizzy.ankudowich@nih.gov

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