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Transforming the understanding
and treatment of mental illnesses.

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ETPB primary image Experimental Therapeutics & Pathophysiology Branch

Participating in Research

Participation in research studies helps transform the understanding and treatment of mental illnesses through basic science and clinical research.

  • Bipolar Disorder Studies
  • Major Depressive Disorder Studies
  • Healthy Volunteers

What types of research does the ETPB do?

The Experimental Therapeutics & Pathophysiology Branch (ETPB) has multiple clinical research studies looking at adults with bipolar disorder, major depressive disorder, and suicide. Healthy Volunteers also take part in our studies to help us understand the differences between individuals with and without mood disorders. We have both inpatient and outpatient research studies.

What types of procedures do study participants do when at the NIH?

Participants in our research studies may undergo a number of evaluations and tests, including,: physical exams, blood draws, medical and psychiatric interviews, questionnaires, Magnetic Resonance Imaging (MRI), Electroencephalography (EEG), Magnetoencephalography (MEG), and Polysomnography (sleep studies).

What is the time commitment?

Your time commitment will vary. Our outpatient and inpatient studies vary from 1 week to approximately 3 to 4 months. Some of our studies may be completed with a combination of inpatient/outpatient and telehealth visits.

What does it cost to participate?

There is no cost to participate in research studies. All treatment associated with research study participation is free of charge. Travel arrangements are provided, and costs covered by NIMH. (Arrangements vary by distance and by specific study.) Standard treatment is provided to participants while transitioning back to the community.

Where are the studies conducted?

Our studies are conducted at the NIH Clinical Center in Bethesda, Maryland, the largest clinical research hospital in the world. Inpatient studies are done on our inpatient Behavioral Health unit in the Clinical Center.

Can I participate if I do not live near NIH?

Yes, our studies enroll eligible participants locally and from around the country. Travel arrangements provided and costs covered by NIMH. (Arrangements vary by distance and by specific study.)

How do I learn more about participating in clinical research studies?

First steps to participate include: calling NIMH, learning study details, asking about your eligibility, and consenting to participate.

If you are interested and would like to find out if you qualify, email the study team ( or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 711].

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