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Section on Behavioral Endocrinology Behavioral Endocrinology Branch


Asthana, S., Diaz Brinton, R., Henderson, V.W., McEwen, B.S., Morrison, J.H., and Schmidt, P.J.: Frontiers proposal. National Institute on Aging “bench to bedside: estrogen as a case study.” Age , 31:199-210, 2009. PMID: 19277902

Schmidt, P.J. and Rubinow, D.R.: Sex hormones and mood in the perimenopause. Ann. NY Acad. Sci. , 1179:70-85, 2009. PMID: 19906233

Rubinow, D.R., Schmidt, P.J., Meltzer-Brody, S., and Harsh, V.: Gonadal hormones and behavior in women: concentrations vs. context. IN: Hormones, Brain and Behavior, Second Edition , A.P. Arnold, A.M. Etgen, S.E. Fahrbach, R.T. Rubin, and D. Pfaff (Eds.). San Diego, CA, Elsevier, Inc., pp. 2395-2428, 2009.

Rubinow, D.R. and Schmidt, P.J.: Reproductive hormone therapy: theory and practice. IN: Kaplan’s and Sadocks’ Comprehensive Textbook of Psychiatry , B.J. Sadock and V.A. Sadock (Eds.). Baltimore, MD, Williams & Wilkens, pp. 3328-3334, 2009.

Miller, A., Vo, H., Huo, L., Roca, C., Schmidt, P.J., and Rubinow, D.R: Estrogen receptor alpha (ESR-1) associations with psychological traits in women with PMDD and controls. J Psychiatr. Res ., 44:788-794, 2010. PMID: 20172536

Maki, P.M., Freeman, E.W., Greendale, G.A., Henderson, V.W., Newhouse, P.A., Schmidt, P.J., Scott, N.F., Shively, C.A., and Soares, C.N.: Summary of the NIA-sponsored Conference on Depressive Symptoms and Cognitive Complaints in the Menopausal Transition. Menopause , 17:815-822, 2010. PMID: 20616668

Schmidt, P.J., Luff, J.A., Haq, N.A., Vanderhoof, V.H., Koziol, D.E., Calis, K.A., Rubinow, D.R., and Nelson, L.M.: Depression in women with spontaneous 46, XX primary ovarian insufficiency. J. Clin. Endocrinol. Metab ., 96:E278-E287, 2011. PMID: 21047929

Epperson, C.N., Eriksson, E., Freeman, E., Halbreich, U., Ismail, K.M.K., Panay, N., Pearlstein, T., Rapkin, A., Reid, R., Schmidt, P., Steiner, M., Studd, J., and Yonkers, K.: Towards a consensus on diagnostic criteria, measurement and trial design of the premenstrual disorders: the ISPMD Montreal consensus. Arch. Womens Ment. Health 14:13-21, 2011. PMID: 21225438

Pincus, S.M., Alam, S., Rubinow, D.R., Bhuvaneswar, C.G., and Schmidt, P.J.: Predicting response to leuprolide of women with premenstrual dysphoric disorder by daily mood rating dynamics. J. Psychiatr. Res ., 45:386-394, 2011. PMID: 20708199

Rubinow, D.R., Crowder, V.L., Schmidt, P.J., and Rubinow, K.B.: Psychoneuroendocrinology. IN: Handbook of Neuroendocrinology , G. Fink, D.W. Pfaff, and J.E. Levine (Eds.). San Diego, CA, Academic Press, Elsevier, 779-790, 2012.

Epperson, C.N., Steiner, M., Hartlage, S.A., Eriksson, E., Schmidt, P.J., Jones, I., and Yonkers, K.A.: Premenstrual dysphoric disorder: evidence for a new category for DSM-5. Am. J. Psychiatry , 169:465-475, 2012. PMID: 22456824

Gass, M.L.S., Manson, J.E., Cosman, F., Grodstein, F., Jordan, V.C., Karas, R.H., Kaunitz, A.M., Maki, P.M., Schmidt, P.J., Shifren, J.L., Stuenkel, C.A., and Utian, W.H.: The 2012 Hormone Therapy Position Statement of the North American Menopause Society. Menopause , 19:257-271, 2012. PMID: 22367731

Lee, E.E., Nieman, L.K., Martinez, P.E., Harsh, V.L., Rubinow, D.R., and Schmidt, P.J.: ACTH and cortisol response to Dex/CRH testing in women with and without premenstrual dysphoria during GnRH agonist-induced hypogonadism and ovarian steroid replacement. J. Clin. Endocrinol. Metab ., 97:1887-1896, 2012. PMID: 22466349

Steinberg, E.M., Cardoso, G.M.P., Martinez, P.E., Rubinow, D.R., and Schmidt, P.J.: Rapid response to fluoxetine in women with premenstrual dysphoric disorder. Depress. Anxiety , 29:531-540, 2012. PMID: 22565858

Gass, M.L.S., Manson, J.E., Stuenkel, C.A., Cosman, F., Grodstein, F., Jordan, V.C., Karas, R.H., Kaunitz, A.M., Maki, P.M., Schmidt, P.J., Shifren, J.L., and Utian, W.H.: The 2012 Hormone Therapy Position Statement of the North American Menopause Society. Letter to the Editor. Menopause , 19:836-837, 2012. PMID: 22668819

Schmidt, P.J., Keenan, P.A., Schenkel, L.A., Berlin, K., Gibson, C., and Rubinow, D.R.: Cognitive performance in healthy women during induced hypogonadism and ovarian steroid addback. Arch. Womens Ment. Health , 16:47-58, 2013. PMID: 23188540

Baller, E.B., Wei, S.M., Kohn, P.D., Rubinow, D.R., Alarcon, G., Schmidt, P.J., and Berman, K.F.: Abnormalities of dorsolateral prefrontal function in women with premenstrual dysphoric disorder: a multimodal neuroimaging study. Am. J. Psychiatry , 170:305-314, 2013. PMID: 23361612

Ben Dor, R., Harsh, V.L., Fortinsky, P., Koziol, D.E., Rubinow, D.R., and Schmidt, P.J.: Effects of pharmacologically-induced hypogonadism on mood and behavior in healthy young women. Am. J. Psychiatry , 170:426-433, 2013. PMID: 23545794

Nevatte, T, O’Brien, P.M.S., Backstrom T., Brown, C., Dennerstein, L., Endicott, J., Epperson, C.N., Eriksson, E., Freeman, E.W., Halbreich, U., Ismail, K., Panay, N., Pearlstein, T., Rapkin, A., Reid, R., Rubinow, D., Schmidt, P., Steiner, M., Studd, J., Sundstrom-Poromaa, I., Yonkers, K., Consensus Group of the International Society for Premenstrual Disorders: ISPMD consensus on the management of premenstrual disorders. Arch. Womens Ment. Health , 16: 279-291, 2013. PMID: 23624686

Rubinow DR, Schmidt PJ, Craft CD. Gonadal steroids and mood disorders. In: Charney D, Buxbaum J, Sklar P, Nestler E, editors. Neurobiology of Mental Illness. 4th ed. New York, NY: Oxford University Press; 2013.

Guerrieri, G.M., Martinez, P.E., Klug, S.P., Haq, N.A., Vanderhoof, V.H., Koziol, K., Popat, V., Rubinow, D.R., Schmidt, P.J., Nelson, L.M.: Effects of Physiologic Testosterone Replacement on Quality of Life, Mood, and Self-Esteem in Women with Spontaneous 46, XX Primary Ovarian Insufficiency. Menopause: The Journal of The North American Menopuase Society , 21:952-961, 2014. PMID: 24473536

Schiller, C.E., Schmidt, P.J., Rubinow, D.R.: Allopregnanolone as a mediator of affective switching in reproductive mood disorders. Psychopharmacology , 17:3557-3567, 2014. PMID: 24846476

The PACT Consortium: Postpartum Depression—Action Towards Causes and Treatment: Heterogeneity of Postpartum Depression: A Latent Class Analysis. The Lancet Psychiatry , 2:59-67, 2015. PMID: 26359613

Ben Dor,R.; Marx,C.E.; Shampine,L.J.; Rubinow,D.R.; Schmidt,P.J.: DHEA metabolism to the neurosteroid androsterone: a possible mechanism of DHEA's antidepressant action. Psychopharmacology 232:3683, 2015. PMID: 26105109

Martinez,P.E.; Rubinow,D.R.; Nieman,L.K.; Koziol,D.E.; Morrow,A.L.; Schiller,C.E.; Cintron,D.; Thompson,K.D.; Khine,K.K.; Schmidt,P.J.: 5alpha-reductase inhibition prevents the luteal phase increase in plasma allopregnanolone levels and mitigates symptoms in women with Premenstrual Dysphoric Disorder. Neuropsychopharmacology Online publication: 1-10, 2015. PMID: 26272051

Schiller,C.E.; Johnson,S.L.; Abate,A.C.; Schmidt,P.J.; Rubinow,D.R.: Reproductive steroid regulation of mood and behavior. Comprehensive Physiology In Press:2015.

Rubinow, D.R., Johnson, S.L., Schmidt, P.J., Girdler, S, Gaynes, B.: Efficacy of Estradiol in Perimenopausal Depression: So much promise and so few answers. Depression and Anxiety , 32: 539-549, 2015. PMID: 26130315

Schmidt,P.J.; Ben Dor,R.; Martinez,P.E.; Guerrieri,G.M.; Harsh,V.L.; Thompson,K.; Koziol,D.E.; Nieman,L.K.; Rubinow,D.R.: Estradiol withdrawal destabilizes mood in women with past perimenopausal depression. JAMA Psychiatry 72:714-726, 2015. PMID: 26018333

Guerrieri, G.M., Wakim, P.G., Keenan, P.A., Schenkel, L.A., Berlin, K., Gibson, C.J., Rubinow, D.R., Schmidt, P.J.: Sex differences in visuospatial abilities persist during induced hypogonadism. Neuropsychologia 81:219-229, 2016. PMID: 26719236

Kepple,A.L.; Lee,E.E.; Haq,N.; Rubinow,D.R.; Schmidt,P.J.: History of postpartum depression in a clinic-based sample of women with premenstrual dysphoric disorder. Journal of Clinical Psychiatry Online 2016.

Di Florio,A.; Putnam,K.; Altemus,M.; Apter,G.; Bergink,V.; Bilszta,J.; Brock,R.; Buist,A.; Deligiannidis,K.M.; Devouche,E.; Epperson,N.C.; Guille,C.; Kim,D.; Lichtenstein,P.; Magnusson,P.K.E.; Martinez,P.; Munk-Olsen,T.; Newport,J.; Payne,J.; Penninx,B.; O’Hara,M., Robertson-Blackmore,E.; Roza,S.; Sharkey,K.; Stuart,S.; Tiemeier,H.; Viktorin,A.; Schmidt.P.; Sullivan,P.F.; Stowe,Z.; Wisner,K.L.; Jones,I.; Rubinow,R.; Meltzer-Brody,S.: The impact of education, country, race and ethnicity on the self-report of postpartum depression using the Edinburgh Postnatal Depression Scale in a large international sample of new mothers. Department of Psychiatry in-press 2016.

Gordon JL, Rubinow DR, Thurston RC, Paulson J, Schmidt PJ, Girdler SS.: Cardiovascular, hemodynamic, neuroendocrine, and inflammatory markers in women with and without vasomotor symptoms. Menopause , 11:1189-1198, 2016. PMID: 27465715

Wariso BA, Guerrieri GM, Thompson K, Koziol DE, Haq N, Martinez PE, Rubinow DR, Schmidt PJ.: Depression during the menopause transition: impact on quality of life, social adjustment, and disability. Archives Women’s Mental Health , 2016. PMID: 28000061

Dubey N, Hoffman JF, Schuebel K, Yuan Q, Martinez PE, Nieman LK, Rubinow DR, Schmidt PJ, Goldman D.: The ESC/E(Z) complex, an effector of response to ovarian steroids, manifests an intrinsic difference in cells from women with premenstrual dysphoric disorder. Molecular Psychiatry In Press: 2017. PMID: 28044059

Shau-Ming Wei, Ph.D., Erica B. Baller, M.D., Philip D. Kohn, M.S., Jonathan S. Kippenhan, Ph.D., Bhaskar Kolachana, Ph.D., Steven J. Soldin, Ph.D., David R. Rubinow, M.D., Peter J. Schmidt, M.D., Karen F. Berman, M.D.: Brain Derived Neurotrophic Factor (BDNF) Val66Met Genotype and Ovarian Steroids Interactively Modulate Working Memory-Related Hippocampal Function in Women: A Multimodal Neuroimaging Study, In Press

Kanes, S.J, Colquhoun, H., Doherty, J., Raines,S., Hoffmann, E., Rubinow, D.,. Samantha Meltzer-Brody, S., Open-label, proof-of-concept study of SAGE-547 (allopregnanolone) in the treatment of severe postpartum depression, In Press. Schmidt, P.,Martinez, P., Nieman, L.K., Koziol, D.E., Thompson, K.D., Schenkel, L.,Wakim, P.G., Rubinow, D.R. Exposure to a change in ovarian steroid levels but not continuous stable levels triggers PMDD symptoms following ovarian suppression. In Press