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Transforming the understanding
and treatment of mental illnesses.

Celebrating 75 Years! Learn More >>

Human Brain Collection Core (HBCC)

For Families

Mission: The mission of the Human Brain Collection Core (HBCC) is to learn about the causes and mechanisms of mental illnesses, which are brain diseases. To be able to conduct this research, we obtain brains from deceased individuals with and without mental illness. The results will help researchers develop new therapies and preventive strategies.

Sources of Donated Brains: We obtain brains through the Office of the Chief Medical Examiner (OCME) of the Central Northern District in Virginia. Our staff are notified of potential donors by the OCMEs. We then contact the primary next-of-kin of the decedent to obtain consent for donation of the entire brain and a blood sample. Our staff audiotape the next-of-kin’s consent as an official record of the donation. Only after obtaining consent, we arrange with the OCMEs to collect the donated brain. There is no cost to the next-of-kin or the decedent’s family. There is no direct benefit to the family for allowing the donation. The donation is strictly voluntary.

Confidentiality: We protect the confidentiality of the decedent by removing his/her name and all identifying information from all materials we receive.

Characterization: To confirm diagnosis, we try to obtain further information about the decedent’s medical and psychiatric history through interviews with the family and released medical records after obtaining written authorization from the next-of-kin. We will accept a donation even if the next-of-kin does not wish to answer follow-up questions. Because of the ongoing nature of the studies, we do not provide any individual research results to the next-of-kin or the families or comments about the cause of death. Families should contact the OCME directly if they have further questions about the decedent.

All our procedures are approved by the HBCC Oversight Committee and by the NIH Department of Bioethics.

Our Research: We and our approved collaborators conduct a vast array of research studies on the neurobiological processes in the brains of people with and without mental illness. We use modern techniques, such as RNA and DNA sequencing, to examine molecular composition of tissues and cells in various brain regions. Visit the section FOR RESEARCHERS if you wish to obtain more information about our research.

Frequently Asked Questions:

Q: If we donate our loved one’s brain will we still be able to have a viewing / open casket?
A: Yes, the medical examiner’s procedure is done in a way so that it will not change or affect the appearance of the deceased.

Q: If I agree to the donation, will that delay the returning of the deceased’s body to me or release to the funeral home?
A: No, there will be no delay as compared with the routine autopsy procedure. The donation process happens very quickly on the same day as the autopsy.

Q: Will donating interfere with the investigation of the cause of death?
A: No, our procedures will help with the investigation. We perform a full neuropathological examination of the donated brain.

Q: Will we receive any report on your findings?
A: Yes, we will generate a report of our examination and provide it to the medical examiner to be included as part of their final autopsy report. Our full report is available through the medical examiner approximately 3 months after the date of donation.

Q: Does your contacting us mean the deceased individual had a mental illness or died by suicide or drug overdose?

A: No, our call to families of the deceased does not imply any specific medical history or cause of death. The OCME refers all individuals to us who pass away suddenly. Only the OCME can provide details on the circumstances and cause of death.

If you need help, please visit these sites:

NIMH Help for Mental Illnesses If you or someone you know has a mental illness, there are ways to get help. Use these resources to find help for you, a friend, or a family member.

The Substance Abuse and Mental Health Services Administration (SAMHSA)  is the agency within the U.S. Department of Health and Human Services that leads public health efforts to advance the behavioral health of the nation. SAMHSA's mission is to reduce the impact of substance abuse and mental illness on America's communities.

NIAAA Alcohol Treatment Locator  will steer you toward evidence-based treatment, which applies knowledge gained through decades of carefully designed scientific research.

The National Suicide Prevention Lifeline  is a 24-hour, toll-free, confidential suicide prevention hotline available to anyone in suicidal crisis or emotional distress. By dialing 1-800-273-TALK (8255), the call is routed to the nearest crisis center in our national network of more than 150 crisis centers.

If you would like to participate in future research by registering for brain donation, please visit this site: 
Brain Donor Project  Its mission is to increase brain donation to advance science, leading to the treatment and cure of neurological, neuropsychiatric and neurodevelopmental disorders and to help people understand the critical need and simplify the process of making the gift.