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Transforming the understanding
and treatment of mental illnesses.

Celebrating 75 Years! Learn More >>

Mood Lability and Affective Dysregulation Program


This program supports research on the neurodevelopmental trajectories and mechanisms of mental illness associated with affect regulation, emotion, and stress reactivity, including mood lability, bipolar disorder, borderline personality disorder, and related phenotypes and prodromal symptomatology. Of interest are studies that examine the developmental course of, periods of vulnerability or sensitivity for, or risk processes related to the onset, progression, recurrence, and remission of these disorders and their relevant components. Of particular interest are studies that link brain development with behavioral development; studies that identify biomarkers for disease progression; studies that identify sensitive periods for typical and atypical developmental trajectories; studies that elucidate biomarkers and mechanisms of disease progression; studies delineating mechanisms of sex and gender differences in the development of these phenotypes; and studies that test integrative models incorporating multiple levels of analysis (biological, behavioral and environmental) across multiple RDoC constructs.


Stacia Friedman-Hill, Ph.D.
Program Chief (Acting)
6001 Executive Boulevard, Room 7105, MSC 9617