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Transforming the understanding
and treatment of mental illnesses.

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Risk and Early Onset of Psychosis Spectrum Disorders


This program supports research on childhood and adolescent psychosis and thought disorders, including genetic phenotypes known to confer risk and prodromal symptomatology. Prospective studies that illuminate mechanisms and trajectories of psychopathology in model animals or humans are welcomed. Of interest are studies that examine the developmental course, periods of vulnerability or sensitivity, or risk processes related to the onset, progression, recurrence, and remission of psychopathology and its relevant components. NIMH strongly encourages use of the RDoC research framework to identify circuits and functional domains that are key to the development of psychosis and can serve as predictive biomarkers. Of particular interest are studies that link brain development with behavioral development, studies that identify biomarkers for disease progression, and studies that test integrative models incorporating biological, behavioral, and environmental/experiential factors in the development of psychopathology.


Stacia Friedman-Hill, Ph.D.
Program Chief
6001 Executive Boulevard, Room 7105, MSC 9617