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Comparing Attention Deficit Hyperactivity Disorder to Severely Impairing Irritability: Investigations of Brain Function

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

To find out if you qualify, email the study team ( or call 1-301-496-8381 [TTY: 711].

This observational research study seeks to learn about the differences between Attention Deficit Hyperactivity Disorder (ADHD) and severely impairing irritability in children. Researchers will describe the moods and behaviors of children and investigate brain function and irritability. Children with ADHD are being invited to participate as a comparison group in a larger research protocol of children with severe irritability.

Currently recruiting ages 8-17, with an ADHD diagnosis to participate in outpatient visits. Potential participants will have a one-day screening visit to determine eligibility. Eligible children will be invited to up to 10 follow-up visits that include diagnostic assessments, questionnaires, memory and thinking tasks, computer tasks, and brain imaging. Children must be medically healthy and not currently suicidal, psychotic, or hospitalized.

The study is conducted at the NIH Clinical Center in Bethesda, Maryland. Both parent and child must agree to the child’s participation in research. Children and parents are compensated for participation and travel. Child can remain on current medications.

To find out if you qualify, email the study team ( or call 1-301-496-8381 [TTY: 711].

Study Identifiers

  • NIMH Protocol Number: 02-M-0021
  • Study Number: 00025935 

Investigator(s): Melissa Brotman, Ph.D.