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Adults: Bipolar Disorder

Join a Research Study: Enrolling nationally from around the country

Investigating the Genetics of Bipolar Disorder in those affected and their family members

Researchers are looking for genes that may affect a person's chances of developing bipolar disorder. You can participate in this research study if you are over 18, have a bipolar diagnosis, or have a family member with bipolar disorder.

This study includes a telephone interview (2-4 hours) and a blood sample (blood work from your physician.) The purpose of this study is to identify genes that may contribute to the development of bipolar disorder (manic depression), and related conditions. Bipolar disorder is a common and potentially life-threatening mood disorder. The tendency to develop bipolar disorder can be inherited, but this is poorly understood and probably involves multiple genes.

This study will use genetic markers to map and identify genes that contribute to bipolar disorder. Families and individuals who have the disorder are asked to contribute personal information and a blood sample to an anonymous national database. This information will aid scientists around the world who are working together to develop better treatments for this serious mood disorder.

To find out if you qualify, email NIMH or call 1-866-644-4363 [TTY: 1-866-411-1010].

Study Identifiers

  • NIMH Protocol Number: 80-M-0083
  • Study Number: 00001174
  • Principal Investigator: Francis McMahon, M.D.
  • Join a Research Study: Enrolling locally from the Washington, D.C. metro region

    NIMH Family Study of Health and Behavior

    The major goal of this study is to examine how mood disorders, anxiety disorders and migraine run in families. We study both genetic and environmental factors that may contribute to these conditions.

    We recruit people ages 21 and over with depression, manic-depression, social phobia, panic, generalized anxiety, migraine and people without any of these problems. Participants are interviewed about medical and mental symptoms and problems, their health behavior, social factors and a variety of other measures related to their health and behavior. Family members ages 8 and over will also be asked to participate. Some families will be invited to participate in further studies of biological and genetic factors.

    To find out if you qualify, email NIMH or call 1-877-250-1560 [TTY: 1-866-411-1010].

    Study Identifiers

    • NIMH Protocol Number: 03-M-0211
    • Study Number: 00071786
  • Principal Investigator: Kathleen R Merikangas, Ph.D.
  • Join a Research Study: Enrolling nationally from around the country

    Suicide and the Brain

    National Institute of Mental Health (NIMH) researchers seek adults 18 to 70, who have a history of attempted suicide but are not currently suicidal, for a study of suicide and brain function. Participation includes up to seven days as an inpatient at the NIH Clinical Center in Bethesda, Maryland. Procedures include blood tests, medical evaluations, brain imaging, sleep studies and psychiatric interviews. Participants do not need to stop their current medications. Compensation and transportation are provided. Pregnant women and individuals with serious medical conditions are not eligible.

    There is no cost to participate. We enroll eligible participants locally and from around the country. Travel arrangements are provided and costs are covered by NIMH (arrangements vary by distance). After completing the study, participants receive short-term follow-up care at the NIH while transitioning back to a provider.

    If you are in a crisis situation, contact your doctor's office, go to the nearest emergency room, or call 911 for emergency services. You can also call the toll-free, 24-hour hotline of the National Suicide Prevention Lifeline, 1-800-273-TALK (1-800-273-8255). Your call will be connected to the crisis center nearest you. Trained staff can help talk you through your crisis.

    To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

    Study Identifiers

    • NIMH Protocol Number: 15-M-0188
    • Study Number: 02543983
  • Principal Investigator: Carlos Zarate Jr, M.D.