Information on Clinical Studies for Patients and Families
Is a Clinical Study the Right Fit for Your Child?
Children go through many phases of development. It can be hard to know if a child’s behavior is a result of normal development or if it’s a sign of something more serious. Occasional outbursts are a normal outcome of being tired, uncomfortable, or frustrated. In some children, these outbursts can be chronic and explosive.
If you feel like you’re constantly walking on eggshells around your child, the study on irritability may be right for your child. Children who enroll in our studies have irritability that significantly affects how they function at home, in school, and with other children.
Current Studies on Irritability and ADHD
We are currently seeking to enroll children for studies on both irritability and attention-deficit/hyperactivity disorder (ADHD) to learn more about research treatment options.
View the brochures below to learn more about both studies.
Are you walking on eggshells around your irritable child?
CRANKY, GRUMPY, MOODY, FRUSTRATED, ANGRY
NIH RESEARCH STUDIES:
Enrolling Children and Adolescents Ages 8 to 17
JOIN A STUDY AT NIH: Children who enroll in our studies have irritability that significantly impacts their functioning at home, in school, and with other children. Eligible children may be offered a diagnostic assessment, a new approach to cognitive behavioral therapy, or non-treatment research options. Child can remain on current medications. Parents and child must agree to the child’s participation.
Eligible children with an ADHD diagnosis may participate as a comparison group in the non-treatment options.
Do you have a child with ADHD?
NIH research study ages 8 to 17
Eligible children may JOIN A STUDY that describes the moods and behaviors of children with an ADHD diagnosis, and investigates brain function and irritability.
Participation includes interviews, research testing, and brain imaging scans conducted over one to ten outpatient visits. Child can remain on current medications. Children must be medically healthy and not currently suicidal, psychotic, or hospitalized. Parents and child must agree to child’s participation.
This study is comparing attention-deficit/hyperactivity disorder (ADHD) to severe irritability in children. There is no cost to participate. Compensation is provided.
What is a clinical research study?
A clinical research study is often called a clinical trial or a protocol. Children must meet the study’s eligibility requirements, and parent and child must consent to participant in a study. Learn more about Clinical Trials at NIMH.
What Types of Studies does NNT conduct?
- 1-day outpatient (onsite or virtual) evaluation
- Study describes moods and behaviors
- Up to 10 follow-up visits (onsite or virtual) that include diagnostic assessments, questionnaires, mobile phone apps, computer tasks and brain imaging
Cognitive Behavioral Therapy (CBT)
- 12 therapy sessions and 20 weeks of evaluation
- Child remains on current medications
- Evaluate techniques and strategies to manage and modify irritability and disruptive behavior
- Will also use technology such as mobile phones to assist with treatment
Childhood Irritability Newsletter
- Exposure therapy for pediatric irritability: Theory and potential mechanisms. Behavior Research and Therapy
- A latent variable approach to differentiating neural mechanisms of irritability and anxiety in youth. Journal of the American Medical Association Psychiatry.
- Irritability in youths: A translational model. Annual Review of Clinical Psychology.
Melissa A. Brotman, PhD
Director, Neuroscience and Novel Therapeutics
Emotion and Development Branch
National Institute of Mental Health
9000 Rockville Pike, Building 15K
Bethesda, Maryland 20892
Phone: (301) 435-6645