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Transforming the understanding
and treatment of mental illnesses.

Neuroscience and Novel Therapeutics Unit (NNT)

Publications

Neuroscience and Novel Therapeutics Unit: Publications

The researchers and staff In the Neuroscience and Novel Therapeutics Unit regularly share the results of research through publications in the world’s premier scientific journals. Read the articles below to learn more about the exciting research taking place at NNT.

View all of Dr. Brotman’s Pubmed Publications.

Publication: Computational modeling of attentional impairments in Disruptive Mood Dysregulation and Attention Deficit/hyperactivity Disorder

Computerized Interpretation Bias Training for Disruptive Mood Dysregulation Disorder: A Fast-Fail Study

SP Haller, J Stoddard, C Botz-Zapp, M Clayton, C MacGillivray, ... (2021). Computerized Interpretation Bias Training for Disruptive Mood Dysregulation Disorder: A Fast-Fail StudyJournal of the American Academy of Child & Adolescent Psychiatry

Rationale and validation of a novel mobile application probing motor inhibition

Rationale and validation of a novel mobile application probing motor inhibition: Proof of concept of CALM-IT

EM Cardinale, R Naim, SP Haller, R German, C Botz-Zapp, J Bezek, ... (2021). Rationale and validation of a novel mobile application probing motor inhibition: Proof of concept of CALM-ITPloS one 16 (6), e0252245

Attention bias to negative versus non-negative faces is related to negative affectivity in a transdiagnostic youth sample

Attention bias to negative versus non-negative faces is related to negative affectivity in a transdiagnostic youth sample

A Harrewijn, R Abend, R Naim, SP Haller, CM Stavish, MA Bajaj, ... (2021). Attention bias to negative versus non-negative faces is related to negative affectivity in a transdiagnostic youth sampleJournal of Psychiatric Research 138, 514-518

Across-subjects multiple baseline trial of exposure-based cognitive-behavioral therapy for severe irritability

Across-subjects multiple baseline trial of exposure-based cognitive-behavioral therapy for severe irritability: a study protocol

R Naim, K Kircanski, A Gold, RE German, M Davis, S Perlstein, M Clayton, ... (2021). Across-subjects multiple baseline trial of exposure-based cognitive-behavioral therapy for severe irritability: a study protocolBMJ open 11 (3), e039169

Publication: Computational modeling of attentional impairments in Disruptive Mood Dysregulation and Attention Deficit/hyperactivity Disorder

Computational modeling of attentional impairments in Disruptive Mood Dysregulation and Attention Deficit/hyperactivity Disorder

Haller, S.P., Stoddard, J., Pagliaccio, D., Bui, H., MacGillivray, C., Brotman, M.A. (in press). Computational modeling of attentional impairments in Disruptive Mood Dysregulation and Attention Deficit/hyperactivity DisorderJournal of the American Academy of Child and Adolescent Psychiatry.

Publication: Self-efficacy as a target for neuroscience research on moderators of treatment outcomes in pediatric anxiety

Self-efficacy as a target for neuroscience research on moderators of treatment outcomes in pediatric anxiety

Lewis, K.M., Matsumoto, C., Cardinale, E., Jones, E.L., Gold, A.L, Stringaris, A., Leibenluft, E., Pine, D.S., Brotman, M.A. (2020). Self-efficacy as a target for neuroscience research on moderators of treatment outcomes in pediatric anxiety. Journal of Child and Adolescent Psychopharmacology, 30, 205-214. DOI: https://doi.org/10.1089/cap.2019.0130

Publication: Exposure-based CBT for disruptive mood dysregulation disorder: An evidence-based case study

Exposure-based CBT for disruptive mood dysregulation disorder: An evidence-based case study

Linke, J.O., Kircanski, K., Brooks, J., Perhamus, G., Gold, A.L., Brotman, M.A. (2020). Exposure-based CBT for disruptive mood dysregulation disorder: An evidence-based case study. Behavior Therapy, 51, 207-364. DOI: 10.1016/j.beth.2019.05.007

Publication: White matter microstructure in pediatric bipolar disorder and disruptive mood dysregulation

White matter microstructure in pediatric bipolar disorder and disruptive mood dysregulation

Linke, J., Stavish, C., Adleman, N., Sarlls, J., Leibenluft, E., Brotman, M.A. (2020). White matter microstructure in pediatric bipolar disorder and disruptive mood dysregulation. Journal of the American Academy of Child and Adolescent Psychiatry, 59, 1135-1145. DOI: 10.1016/j.jaac.2019.05.035

Publication: The Clinician Affective Reactivity Index: Validity and reliability of a clinician-rated assessment of irritability

The Clinician Affective Reactivity Index: Validity and reliability of a clinician-rated assessment of irritability

Haller, S.P., Kircanski, K., Stringaris, A., Clayton, M., Bui, H., Agorsor, C., Cardenas, S.I., Towbin, K.E., Pine, D.S., Leibenluft, E., Brotman, M.A. (2020). The Clinician Affective Reactivity Index: Validity and reliability of a clinician-rated assessment of irritability. Behavior Therapy, 51, 283-293. DOI: 10.1016/j.beth.2019.10.005

Publication: White matter microstructure in youth with and at risk for bipolar disorder

White matter microstructure in youth with and at risk for bipolar disorder

Linke, J.O., Stavish, C., Adleman, N.E., Sarlls, J., Towbin, K.E., Pine, D.S., Leibenluft, E., Brotman, M.A. (2020). White matter microstructure in youth with and at risk for bipolar disorder. Bipolar Disorders, 22, 163-173. DOI: https://doi.org/10.1111/bdi.12885

Publication: Efficacy and mechanisms underlying a gamified attention-bias modification training in anxious youth: Protocol for a randomized controlled trial

Efficacy and mechanisms underlying a gamified attention-bias modification training in anxious youth: Protocol for a randomized controlled trial

Linke, J.O., Pagliaccio, D., Lewis, K., Silverman, W., Bar-Haim, Y., Pine, D.S., Brotman, M.A. (2019). Efficacy and mechanisms underlying a gamified attention-bias modification training in anxious youth: Protocol for a randomized controlled trial. BMC Psychiatry, 19, 246. DOI: https://doi.org/10.1186/s12888-019-2224-2

Publication: Exposure therapy for pediatric irritability: Theory and potential mechanisms

Exposure therapy for pediatric irritability: Theory and potential mechanisms

Kircanski, K., Craske, M.G., Averbeck, B.B., Pine, D.S., Leibenluft, E., Brotman, M.A. (2019). Exposure therapy for pediatric irritability: Theory and potential mechanisms. Behaviour Research and Therapy, 118, 141-149. DOI: 10.1016/j.brat.2019.04.007

Publication: Parsing neurodevelopmental features of irritability and anxiety: Replication and validation of a latent variable approach

Parsing neurodevelopmental features of irritability and anxiety: Replication and validation of a latent variable approach

Cardinale, E.M., Kircanski, K., Brooks, J., Gold, A.L., Towbin, K.E., Pine, D.S., Leibenluft, E., Brotman, M.A. (2019). Parsing neurodevelopmental features of irritability and anxiety: Replication and validation of a latent variable approach. Development and Psychopathology, 31, 917-929. DOI: 10.1017/S095457941900035X

Publication: A Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth

A latent variable approach to differentiating neural mechanisms of irritability and anxiety in youth

Kircanski, K., White, L.K., Tseng, W.-L., Wiggins, J.L., Frank, H., Sequeira, S., Zhang, S., Abend, R., Towbin, K.E., Stringaris, A., Pine, D.S., Leibenluft, E., Brotman, M.A. (2018). A latent variable approach to differentiating neural mechanisms of irritability and anxiety in youth. Journal of the American Medical Association Psychiatry, 75, 631-639. PMID:29625429 DOI: 10.1001/jamapsychiatry.2018.0468

Publication: Psychosocial treatment of irritability in youth

Psychosocial treatment of irritability in youth

Kircanski, K., Clayton, M.E., Leibenluft, E., Brotman, M.A. (2018). Psychosocial treatment of irritability in youth. (2018). Current Treatment Options in Psychiatry, 5, 129-140. DOI: 10.1007/s40501-018-0141-5

Publication: Irritability in youths: A translational model

Irritability in youths: A translational model

Brotman, M.A., Kircanski, K., Stringaris, A., Pine, D.S., Leibenluft, E. (2017). Irritability in youths: A translational model. American Journal of Psychiatry, 174, 520-532. PMID: 28103715 DOI:10.1176/appi.ajp.2016.16070839

Publication: Irritability in children and adolescents

Irritability in children and adolescents

Brotman, M.A., Kircanski, K., Leibenluft, E. (2017). Irritability in children and adolescents. Annual Review of Clinical Psychology, 13, 317-341. PMID: 28482689 DOI:10.1146/annurev-clinpsy-032816-044941

Publication: Identifying moderators of the adherence-outcome relation in cognitive therapy for depression

Identifying moderators of the adherence-outcome relation in cognitive therapy for depression

Sasso, K.E., Strunk, D.R., Braun, J.D., DeRubeis, R.J., Brotman, M.A. (2015). Identifying moderators of the adherence-outcome relation in cognitive therapy for depression. Journal of Consulting and Clinical Psychology, 83, 976-984. PMID: 26214542 DOI: 10.1037/ccp0000045

Publication: Amygdala activation during emotion processing of neutral faces in children with severe mood dysregulation versus ADHD or bipolar disorder

Amygdala activation during emotion processing of neutral faces in children with severe mood dysregulation versus ADHD or bipolar disorder

Brotman, M.A., Rich, B.A., Guyer, A.E., Lunsford, J.R., Horsey, S.E., Reising, M.M., Thomas, L.A., Fromm, S.J., Towbin, K., Pine, D.S., Leibenluft, E. (2010). Amygdala activation during emotion processing of neutral faces in children with severe mood dysregulation versus ADHD or bipolar disorder. American Journal of Psychiatry, 167, 61-69. PMID:19917597 PMCID: PMC3075433 DOI: 10.1176/appi.ajp.2009.09010043

Publication: Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children

Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children

Brotman, M.A., Schmajuk, M., Rich, B.A., Dickstein, D.P., Guyer, A.E., Costello, E.J., Egger, H.L., Angold, A., Pine, D.S., Leibenluft, E. (2006). Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children. Biological Psychiatry, 60, 991-997. PMID:17056393 DOI: 10.1016/j.biopsych.2006.08.042