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Transforming the understanding
and treatment of mental illnesses.

Noninvasive Neuromodulation Unit (NNU) Noninvasive Neuromodulation Unit (NNU)

Current Studies

DECIBELS: DiscovEring CortIcal BiomarkErs in Language processing in adolescents with autism spectrum disorderS

Do you meet the following criteria and are interested in participating?

Non-ASD: All sexes, 18-25 years old

ASD: All sexes, right-handed, 14-17 years old, verbal (coming mid-2022)

About the Study

Are you a healthy young adult with no neurological, psychiatric, or general medical condition 18-25 and interested in learning more about how your brain processes language? If so, you may be eligible to participate in the pilot phase of a new research study at NIMH.

This outpatient study involves about three visits. The visits may be split up to shorten the length of visit and limit fatigue. Visits will be scheduled about once a week. All visits must be completed within six months of the date of enrollment. Participation involves behavioral evaluations, brain scans, and active transcranial magnetic stimulation (TMS).

This study is conducted at the NIH campus in Bethesda, Maryland. Compensation will be provided for your time. Parking will be validated; however, no reimbursement will be provided for travel or lodging.

For more information, please visit https://decibels.ctss.nih.gov

To find out if you qualify, email decibels-study@mail.nih.gov or call 1-301-827-8403 [TTY: 1-866-411-1010].

https://clinicaltrials.gov/ct2/show/NCT04798274 - Role of GABAergic Transmission in Auditory Processing in Autism Spectrum Disorder

Depression, Experimental ECT and Brain Imaging (iLAST)

Do you meet the following criteria and interested in participating?

All sexes, 22-70 years old, diagnosed with Major Depressive Disorder (MDD), and eligible for electroconvulsive therapy (ECT)

About the Study

This research study is testing a new type of electroconvulsive therapy (ECT) to see if it is a safe and effective method to rapidly reduce and treat depression. With this new type of ECT we decrease the strength of the electric pulse to see if that causes less memory side effects than regular ECT. We use brain imaging to better understand how the new treatment affects the brain and how this relates to changes in depression or memory.

This inpatient study is enrolling adults with major depressive disorder, ages 22-70. Participants will be free of other serious medical conditions and have tried other treatments and failed to improve. Research participation is 4- to 12-weeks and includes 7 sessions of the experimental ECT, brain imaging, transcranial magnetic stimulation (TMS) assessment, and memory and thinking assessments. All research participants will receive 10-12 sessions of regular ECT after the experimental ECT part is over.

The study is conducted at the NIH Clinical Center in Bethesda, MD. There is no cost to participate and compensation is provided. This study enrolls eligible participants from across the USA. Travel arrangements are provided, and costs are covered by NIMH (arrangements vary by distance). After completing the study, participants receive short-term follow-up care at the NIH while transitioning back to a provider.

To find out if you qualify, email NIMH or call 1-301-480-4244 [TTY: 1-866-411-1010].

https://www.clinicaltrials.gov/ct2/show/NCT03895658 - Safety and Feasibility of Individualized Low Amplitude Seizure Therapy (iLAST)

Depression, TMS, Psychotherapy and Brain Function

Do you meet the following criteria and interested in participating?

All sexes, 18-65 years old with DSM-IV-TR primary diagnosis of initial or recurrent Major Depressive Disorder (MDD) and current episode duration between 8 weeks and 5 years

About the Study

This research study seeks depressed participants to test the effects of the combination of repetitive transcranial magnetic stimulation (TMS) and psychotherapy on brain function.

This study is enrolling eligible adults ages 18-65 with major depressive disorder, who are free of other serious medical conditions. If you are currently taking anti-depressants, you may still be eligible.

This inpatient and/or outpatient study involves daily visits for 6 weeks followed by once-monthly visits for 3 months. Participation includes research evaluations, brain scans, and active TMS and psychotherapy, or inactive TMS and psychotherapy. Those who received inactive TMS may receive active TMS after the experimental phase is completed. After completing the study, participants receive short-term care at the NIH while transitioning back to a provider. The 3 monthly follow up visits can be conducted via telephone.

All clinical evaluations, research tasks and visits are free of cost. Participants are compensated for research procedures. The study is conducted at the NIH in Bethesda, Maryland, and is enrolling participants nationwide, from across the United States. Travel arrangements are provided and costs are covered by NIMH (arrangements vary by distance).

To find out if you qualify, email NIMH or call 1-301-827-1874 [TTY: 1-866-411-1010].

https://www.clinicaltrials.gov/ct2/show/NCT03289923 - Concurrent fMRI-guided rTMS and Cognitive Therapy for the Treatment of Major Depressive Episodes

TMS and Brain Function

Do you meet the following criteria and interested in participating?

All sexes, 18-65 years old, free of serious medical conditions

About the Study

This research study seeks healthy adult participants to explore how transcranial magnetic stimulation (TMS) affects the brain. TMS is a non-invasive method which uses a magnet placed outside the head to stimulate precise locations inside the brain.

This study is enrolling eligible adults ages 18-65 who are free of serious medical conditions. Participation includes three to four outpatient visits for research evaluations, brain scans, and TMS. All clinical evaluations, research tasks and visits are free of cost. Participants are compensated. The study is conducted at the NIH in Bethesda, Maryland.

To find out if you qualify, email NIMH or call 1-301-827-1651.

https://www.clinicaltrials.gov/ct2/show/NCT03351764 - Development of Non-Invasive Brain Stimulation Techniques