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Adults: Depression

Join a Research Study: Enrolling nationally from around the country

Depression, Ketamine and Alcohol

Researchers are evaluating rapid antidepressant effects in the brain. This inpatient study is enrolling eligible adults, ages 21 to 65, who are free of other serious medical conditions, for 4-7 weeks as research participants. Procedures may include tapering off antidepressants, a medication-free period, two infusions of alcohol and one infusion of low-dose ketamine (an FDA-approved anesthetic), and two brain scans (MRI).

The study is conducted at the NIH Clinical Center in Bethesda, MD. There is no cost to participate and compensation is provided. This study enrolls eligible participants from across the USA. Travel arrangements are provided and costs are covered by NIMH (arrangements vary by distance). After completing the study, participants receive short-term follow-up care at the NIH while transitioning back to a provider.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1222].

Join a Research Study: Enrolling nationally from around the country

Depression, Repeated Doses of Ketamine, and Neuroimaging

The purpose of this study is to evaluate the rapid and sustained antidepressant effects of repeat doses of ketamine in the brain. We want to learn how ketamine affects areas of the brain important in regulating mood and if there are unique signatures that could help predict who may respond to the drug. Also, we want to see if repeated doses of ketamine are safe and effective in treating the symptoms of depression.

We are enrolling eligible adults, ages 18 to 65 with major depressive disorder. This inpatient study lasts 14-20 weeks and procedures include a medication taper and drug-free period, taking repeated doses of the research drug, taking placebo, multiple brain imaging scans, transcranial magnetic stimulation, and psychological testing. After completing the study, participants can receive short-term care at the NIH while transitioning back to a provider.

The study is conducted at the NIH Clinical Center in Bethesda, MD. There is no cost to participate and compensation is provided. This study enrolls eligible participants from across the USA. Travel arrangements are provided and costs are covered by NIMH (arrangements vary by distance). After completing the study, participants receive short-term follow-up care at the NIH while transitioning back to a provider.

First steps to participate include, calling NIMH, learning study details, asking about your eligibility, and consenting to participate.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Depression and Brain Changes in Fear and Anxiety

The purpose of this research study is to better understand how the brain and body work when a person with depression feels anxious.

Research Participation Includes: 1-3 outpatient visits, computer tasks, and exposure to unpleasant stimuli and a brain scan (functional Magnetic Resonance Imaging (fMRI).

Who Can Participate: Depressed adults between the ages of 18-50, who are free of psychiatric medications and certain medical conditions.

You may not be eligible is you are pregnant, have a pacemaker, current alcohol or substance abuse problems, heart disease, neurological disease, or any health problems that would interfere with the study or make it unsafe for you.

The study is conducted at the NIH Clinical Center in Bethesda, Maryland. The testing sessions will take up to 2.5 hours. There is no cost to participate and compensation is provided. This study does not include treatment.

First Steps to Participate in Research: Learn study details, ask about your eligibility, and consent to participate.

To find out if you qualify, email NIMH or call 1-301-451-5087 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling nationally from around the country

Depression Evaluations for Medication and Brain Imaging Studies

This study screens for various inpatient and outpatient studies that investigate the brain and experimental medications (such as ketamine and AV101) to quickly lift severe and hard-to-treat depressive symptoms.

Participation may include outpatient visits or inpatient stays lasting 4 to 12 weeks at the NIH Clinical Center, Bethesda, MD. Procedures may include: tapering off current psychiatric medications, a medication-free period, oral or intravenous medication versus placebo, and brain scans. You may also qualify for other studies that have different requirements and lengths of stay.

Participants must be ages 18-70 and free of serious medical conditions. These studies may enroll eligible participants from across the USA. Travel arrangements and compensation are provided. There is no cost to participate.

First steps to participate include, calling NIMH, learning study details, asking about your eligibility, and consenting to participate.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Enrolling nationally from around the country

Major Depression and AV101

The primary purpose of this research study is to evaluate the safety and effectiveness of the oral drug AV-101 (an antagonist of the glycine receptor) versus placebo. The study aims to determine if this experimental drug has antidepressant effects and fewer side effects than other novel treatments for depression.

We are enrolling moderately depressed individuals between the ages of 18 and 65 with hard-to-treat major depressive disorder. This inpatient study lasts up to 14 weeks and procedures include a medication taper, taking the research drug, taking placebo and 4 brain imaging scans. Optional procedures include a lumbar puncture and a catheter placement in the spine two times. After completing the study, participants receive short-term follow-up care at the NIH while transitioning back to a provider.

The study is conducted at the NIH Clinical Center in Bethesda, Maryland and enrolls eligible participants from across the USA. Travel arrangements are provided and costs are covered by NIMH (arrangements vary by distance). There is no cost to participate and compensation is provided.

First steps to participate include calling NIMH, learning specifics about the study, asking about your eligibility, and consenting to participate.

 

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

NIMH Family Study of Health and Behavior

The major goal of this study is to examine how mood disorders, anxiety disorders and migraine run in families. We study both genetic and environmental factors that may contribute to these conditions.

We recruit people ages 21 and over with depression, manic-depression, social phobia, panic, generalized anxiety, migraine and people without any of these problems. Participants are interviewed about medical and mental symptoms and problems, their health behavior, social factors and a variety of other measures related to their health and behavior. Family members ages 8 and over will also be asked to participate. Some families will be invited to participate in further studies of biological and genetic factors.

To find out if you qualify, email NIMH or call 1-877-250-1560 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling nationally from around the country

Suicide and the Brain

National Institute of Mental Health (NIMH) researchers seek adults 18 to 70, who have a history of attempted suicide but are not currently suicidal, for a study of suicide and brain function. Participation includes up to seven days as an inpatient at the NIH Clinical Center in Bethesda, Maryland. Procedures include blood tests, medical evaluations, brain imaging, sleep studies and psychiatric interviews. Participants do not need to stop their current medications. Compensation and transportation are provided. Pregnant women and individuals with serious medical conditions are not eligible.

There is no cost to participate. We enroll eligible participants locally and from around the country. Travel arrangements are provided and costs are covered by NIMH (arrangements vary by distance). After completing the study, participants receive short-term follow-up care at the NIH while transitioning back to a provider.

If you are in a crisis situation, contact your doctor's office, go to the nearest emergency room, or call 911 for emergency services. You can also call the toll-free, 24-hour hotline of the National Suicide Prevention Lifeline, 1-800-273-TALK (1-800-273-8255).  Your call will be connected to the crisis center nearest you. Trained staff can help talk you through your crisis.

 

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1222].