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and treatment of mental illnesses.

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TMS for Youth with Treatment-Resistant Major Depressive Disorder

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

To find out if you qualify, email the study team ( ) or call 301-827-1350 [TTY: 711].

This research study seeks to learn more about a Transcranial Magnetic Stimulation (TMS) device to treat depression in youth. TMS is a promising treatment cleared by the FDA for adults who have depression and have failed at least one antidepressant medication. 

33% of teens remain depressed even after receiving treatment with medication or talk therapy. We are studying TMS as a possible treatment for youth who are still depressed after receiving medications and talk therapy for depression.

This study is enrolling teens:

  • Ages 13 to 17 years who are currently depressed, and do not have psychosis, bipolar disorder, or autism spectrum disorder, and do not have a current substance use disorder.
  • Have received at least psychotherapy and a medication for depression.

This outpatient study lasts about 14 weeks, and includes:

  • TMS sessions plus Cognitive-Behavioral Therapy (talk therapy) 
  • Questionnaires, neuropsychological testing, brain imaging, other procedures
  • No costs, participants are compensated for participation. 
  • Transportation costs may be reimbursed. 

The study involves visits at the NIH Clinical Center in Bethesda, Maryland. Parents and teenager must agree to the teenager’s participation.

To find out if you qualify, email the study team ( ) or call 301-827-1350 [TTY: 711].

Study Identifiers

  • NIMH Protocol Number: 000776
  • Study Number: 05652465 

Investigator(s): Daniel Pine, M.D.