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Menopause and Mood

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

To find out if you qualify, email NIMH or call 1-301-496-9576 [TTY: 711].

Researchers are working to understand depression related to the menopause transition. This placebo controlled research study will test whether an experimental medication, Lily compound LY500307, can prevent depression that may occur after suddenly stopping Estrogen Therapy (ET). This drug acts like estrogen, but has a more limited range of effects.

This 7-week outpatient study at the NIH Clinical Center in Bethesda, MD includes daily ratings on a computer, study medication or placebo, and weekly appointments including routine laboratory tests, blood draws, and clinical questionnaires.

If you are a post-menopausal woman age 45 to 65 who struggled with irritability, anxiety, sadness or depression during the perimenopause and your symptoms improved with the use of hormones, please call us to learn more. There is no cost to participate. Compensation is provided. Participants must be free of current psychiatric disorders, psychiatric medications and certain medical conditions.

Study Identifiers

  • NIMH Protocol Number: 18-M-0144
  • Study Number: 03689543

Investigator(s): Peter Schmidt, M.D.