Distribution of Resources
The National Institutes of Health (NIH) promotes the sharing of resources and data as a way to speed the translation of findings into knowledge, and endorse projects and procedures that improve health, while protecting the privacy of research participants.
The Human Brain Collection Core (HBCC) collects postmortem human brain tissue specimens that have been extensively characterized in clinical, toxicological, molecular biological, genetic and neuropathological domains. This collection of more than a thousand individuals with and without major psychiatric disorders and tens of thousands of biospecimens, including blood, tissue, RNA and DNA samples, is an extraordinarily valuable resource that is made accessible to investigators within and outside the NIH to hasten the pathophysiological and etiological understanding of neuropsychiatric illness.
Currently, the HBCC resources include brain tissues (varying brain regions and amounts available) from individuals with the following diagnoses:
|Attention Deficit Disorder||9|
|Depressive disorder (not otherwise specified)||29|
|Obsessive compulsive disorder||10|
|Mental disorder (not otherwise specified)||2|
|Psychosis (not otherwise specified)||3|
|Post-traumatic stress disorder (PTSD)||4|
|Schizophrenia and schizoaffective disorder||193|
|Substance use disorder||23**|
|Major depressive disorder (MDD)||217|
|Lewy Body disease||2|
|Traumatic brain injury/seizure||3|
|Diffuse polyglucosan bodies disease||2|
** multiple substances, including cocaine, heroin, opiates
Other resources include:
- cDNA libraries constructed from dorsolateral prefrontal cortex (DLPFC), hippocampus, anterior cingulate cortex (ACC) and subgenual cingulate cortex (sgACC), and dura from hundreds of subjects with mental disorders and controls
- microarray data (publicly available at dbGAP accession ID: phs000979.v1.p1) from DLPFC, hippocampus and dura,
- frozen sections (14 um thick) mounted on slides (DLPFC from 32 patients with schizophrenia and 63 controls),
- formalin-fixed coronal slices (approximately 15 mm thick) of a single hemisphere from 15 controls, 10 patients with schizophrenia, 5 with major depression, 4 with bipolar disorder.
As a non-renewable resource, the human brain collection requires oversight and evaluation to ensure that specimens are distributed equitably and fairly to investigators. Requests for access to samples from the collection should be emailed to email@example.com. Requests are reviewed for consistency with NIMH and HBCC mission and goals by an oversight committee. Requestor’s objectives will be evaluated for viability and practicality given the limited materials available. Committee members will review the requests and reply to the requestor with their recommendations and comments within 14 working days.
NIH investigators whose request has been approved will complete the Human Tissue Distribution Agreement form; investigators outside NIH will complete the Material Transfer Agreement (MTA).