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Adults: Healthy Volunteers

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Attention and Memory Research Study

This research study seeks to understand if two commonly prescribed medications affect attention and anxiety while performing computer-based tasks. The study involves one assessment visit and two outpatient visits.

The study is enrolling healthy participants ages 18-50. You may be eligible if you no current psychiatric disorder and are free of certain medical conditions.

You may not be eligible is you are pregnant or nursing, have heart disease, neurological disease, certain mental health disorders, or any health problems that would interfere with the study or make it unsafe for you.

Research Participation Includes: Taking one dose of a medication: either Ritalin, Inderal, or placebo (an inactive pill), and performing computer tasks under stressful conditions. Participation may include a brain scan (functional Magnetic Resonance Imaging (fMRI).

The study is conducted at the NIH Clinical Center, America’s research hospital, located on the Metro red line (Medical Center stop) in Bethesda, MD. Parking is provided at no cost. There is no charge for study related procedures and compensation is provided.

First Steps to Participate in Research: Learn study details, ask about your eligibility, and consent to participate. Refer to study no. 14-M-0114. Se habla español.

To find out if you qualify, email NIMH or call 1-301-451-5087 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Become a Healthy Volunteer: Anxiety Study

The purpose of this research study is to better understand how an experimental drug (vasopressin) affects the brain and body when healthy volunteers feel anxious.

Research Participation Includes: 4 outpatient visits, computer tasks, exposure to unpleasant stimuli, and taking an experimental drug and placebo each over 5 to 7 days. Researchers will assess changes in heart rate, muscle activity, sweat responses, and respiration.

Who Can Participate: Healthy volunteers between the ages of 21-50, who have no current psychiatric disorder and are free of certain medical conditions.

You may not be eligible if you are pregnant, have current drug or alcohol abuse, heart disease, neurological disease, or any health problems that would interfere with the study or make it unsafe for you.  

The study is conducted at the NIH Clinical Center in Bethesda, Maryland. The testing sessions may take up to 3 hours. There is no cost to participate and compensation is provided.

First Steps to Participate in Research: Call to learn study details, ask about your eligibility, and consent to participate.

To find out if you qualify, email NIMH or call 1-301-402-4961 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Brain and Body Responses to Stress Study

The purpose of this research study is to better understand how the brain and body work when healthy volunteers feel anxious.

Research Participation Includes: 1-4 outpatient visits, computer tasks, and exposure to unpleasant stimuli. Researchers will assess changes in heart rate, muscle activity, sweat responses, and respiration.

Who Can Participate: Healthy volunteers between the ages of 18-50, who have no current psychiatric disorder and are free of certain medical conditions.

You may not be eligible if you are pregnant, have current drug or alcohol abuse, heart disease, neurological disease, or any health problems that would interfere with the study or make it unsafe for you.  

The study is conducted at the NIH Clinical Center in Bethesda, Maryland. The testing sessions may take up to 3 hours. There is no cost to participate and compensation is provided.

First Steps to Participate in Research: Learn study details, ask about your eligibility, and consent to participate.

To find out if you qualify, email NIMH or call 1-301-402-4961 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Brain and Cognition Research Study

Researchers are enrolling healthy volunteers for an outpatient research study to learn more about how the brain works.

Research participation may include cognitive tasks, personality tests, brain imaging and/or magnetoencephalography (MEG).  Participants may choose which research tasks they would like to participate in, which determines the number of visits (1-12) to the NIH Clinical Center in Bethesda, MD.

The study is enrolling eligible participants, between the ages of 18 and 65, who are in good physical health, and at least a high school education. There is no cost to participate and compensation is provided.

To find out if you qualify, email NIMH or call 1-301-435-5028 [TTY: 1-866-411-1222].

Join a Research Study: Healthy Volunteers

Brain Changes in Fear and Anxiety Study

The purpose of this research study is to better understand how the brain and body work when healthy volunteers feel anxious.

Research Participation Includes: 1-3 outpatient visits, computer tasks, and exposure to unpleasant stimuli and a brain scan (functional Magnetic Resonance Imaging (fMRI).

Who Can Participate: Healthy volunteers between the ages of 18-50, who have no current psychiatric disorder and are free of certain medical conditions.

You may not be eligible is you are pregnant, have pacemaker, current alcohol or substance abuse problems, heart disease, neurological disease, or any health problems that would interfere with the study or make it unsafe for you.  

The study is conducted at the NIH Clinical Center in Bethesda, Maryland. The testing sessions will take up to 2.5 hours. There is no cost to participate and compensation is provided.

First Steps to Participate in Research: Learn study details, ask about your eligibility, and consent to participate.

To find out if you qualify, email NIMH or call 1-301-451-5087 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers

The purpose of this study is to understand brain development during childhood and brain changes with aging. We will look at brain changes and development in healthy adults and children. We will also look at brain changes and development in people with different developmental disorders, including sex chromosome variations.

Previous studies have shown that parts of the brain develop at different times. They have also shown that brain development can be different in people with various diseases. However, we do not fully understand normal brain development and aging. We do not know how it differs in people with certain illnesses that affect thinking and behavior. We are just starting to understand how genes can affect brain development. This study examines the relationship between genes, brain development, and behavior throughout life.  Participants have a research testing visit at the start of the study, and again every 2 years. We will use tests including brain imaging with magnetic resonance imaging (MRI). We will also use physical and psychological examination and evaluation, and genetic testing. We may also ask you to have a skin biopsy, which is described in a separate consent form. We hope that a better understanding of brain development may lead to improved prevention and treatment of mental and behavioral disorders in the future.

This study includes people in good physical health, who are over 3 years old. People in this study may be without any known psychiatric/medical conditions, or may have known conditions such as Sex Chromosome Variation, Autism Spectrum Disorder, Obsessive Compulsive Disorder, and ADHD.

In this part of the study we are currently enrolling healthy volunteers 5-25 years old without current or past psychiatric or neurological diagnoses.

Healthy Volunteers will have an initial visit lasting about 6 hours and will be invited to return every two years. Procedures include a physical examination, a blood draw, an MRI scan of the brain, and cognitive tests of thinking, memory, and attention.  We may also ask you to have a skin biopsy.

The study is conducted at the NIH Clinical Center in Bethesda, Maryland (just outside Washington, D.C. There is no cost to participate in this outpatient visit and compensation is provided. Children must have parental permission to participate.

To find out if you qualify, email NIMH or call 1-301-435-4516 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Brain Stimulation in Fear and Anxiety Study

The purpose of this research study is to see how brain stimulation, transcranial magnetic stimulation (TMS), affects fear and anxiety.

Research participation includes 2 outpatient study visits, 1 to 2 weeks apart, lasting up to 3 hours each. During one study visit a memory task is performed during one of several brain scans [functional Magnetic Resonance Imaging (fMRI)]. In the second study visit, participants receive transcranial magnetic stimulation (TMS) and complete a computer task while exposed to unpleasant stimuli. Researchers will assess brain images, changes in heart rate, muscle activity, sweat responses, and respiration.

This study is enrolling healthy adults between the ages of 18-50 who have no current psychiatric disorders.

These outpatient visits are conducted at the NIH Clinical Center in Bethesda, Maryland. There is no cost to participate and compensation is provided. First steps to participate include calling NIMH, learning study details, asking about your eligibility, and consenting to participate.

To find out if you qualify, email NIMH or call 1-301-402-4961 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Healthy Research Volunteer Study

People in good health are invited to participate as a research study volunteer. Study participants play a vital role in biomedical research by helping scientists advance knowledge and better understand, treat, and ultimately, improve health.

The National Institute of Mental Health (NIMH) is conducting this study to create a list of healthy research volunteers who are interested in participating in additional NIMH studies. Data from healthy research volunteers compared to data from those with mental health conditions can help us understand why some people are affected while others are not.

We invite adults in good health, over age 18, to join the online part of the study by:

  • Registering and consenting to be in the study
  • Completing questions about your medical and mental health

Volunteers for the study will complete online questionnaires  which will take about 20 minutes. They can save and come back to the questionnaires, if needed. 

After completing questionnaires, those who are eligible for an in-person appointment may be invited to the NIH Clinical Center in Bethesda, Maryland. This part of the study may include:

  • Psychological and cognitive assessments
  • Physical exam, blood and urine tests
  • Learning about additional study opportunities, as well as  a brain scan (MRI) for this volunteer study 

There is no cost to participate, and compensation is provided for the in-person appointment. To join the study, sign up on this website

To find out if you qualify, email NIMH or call 1-240-665-0697 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Memories and How the Brain Works

Researchers are enrolling healthy volunteers for an outpatient research study to learn about the brain. A part of the study evaluates how the brain activates and represents memories. Participants will watch videos created in the “1 Second Everyday App” during a brain scan (MRI) and again during a MEG (magnetoencephalography) scan.

The study is currently enrolling eligible participants, between the ages of 18 and 65, who are in good physical health, and have at least a high school education. The study takes 4 hours and procedures include a physical exam, brain and MEG scans, and behavioral tasks.

The is conducted at the NIH Clinical Center in Bethesda, Maryland. There is no cost to participate and compensation is provided. 

To find out if you qualify, email NIMH or call 1-301-451-4412 [TTY: 1-866-411-1010].