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Adults: Healthy Volunteers

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Brain and Body Responses to Stress Study

The purpose of this research study is to better understand how the brain and body work when healthy volunteers feel anxious.

Research Participation Includes: 1-4 outpatient visits, computer tasks, and exposure to unpleasant stimuli. Researchers will assess changes in heart rate, muscle activity, sweat responses, and respiration.

Who Can Participate: Healthy volunteers between the ages of 18-50, who have no current psychiatric disorder and are free of certain medical conditions.

You may not be eligible if you are pregnant, have current drug or alcohol abuse, heart disease, neurological disease, or any health problems that would interfere with the study or make it unsafe for you.  

The study is conducted at the NIH Clinical Center in Bethesda, Maryland. The testing sessions may take up to 3 hours. There is no cost to participate and compensation is provided.

First Steps to Participate in Research: Learn study details, ask about your eligibility, and consent to participate.

Information Regarding Study And Survey

To find out if you qualify, email NIMH or call 1-301-402-4961 [TTY: 1-866-411-1010].

Study Identifiers

  • NIMH Protocol Number: 01-M-0185
  • ClinicalTrials.gov Study Number: 00026559
  • Principal Investigator: Christian Grillon, Ph.D.
  • Join a Research Study: Enrolling locally from the Washington, D.C. metro region

    Brain and Cognition Research Study

    Researchers are enrolling healthy volunteers for an outpatient research study to learn more about how the brain works.

    Research participation may include cognitive tasks, personality tests, brain imaging and/or magnetoencephalography (MEG).  Participants may choose which research tasks they would like to participate in, which determines the number of visits (1-12) to the NIH Clinical Center in Bethesda, MD.

    The study is enrolling eligible participants, between the ages of 18 and 65, who are in good physical health, and at least a high school education. There is no cost to participate and compensation is provided.

    To find out if you qualify, email NIMH or call 1-301-827-5157 [TTY: 1-866-411-1010].

    Study Identifiers

    • NIMH Protocol Number: 93-M-0170
    • ClinicalTrials.gov Study Number: 00001360

    Join a Research Study: Healthy Volunteers

    Brain Changes in Fear and Anxiety Study

    The purpose of this research study is to better understand how the brain and body work when healthy volunteers feel anxious.

    Research Participation Includes: 1-3 outpatient visits, computer tasks, and exposure to unpleasant stimuli and a brain scan (functional Magnetic Resonance Imaging (fMRI).

    Who Can Participate: Healthy volunteers between the ages of 18-50, who have no current psychiatric disorder and are free of certain medical conditions.

    You may not be eligible is you are pregnant, have pacemaker, current alcohol or substance abuse problems, heart disease, neurological disease, or any health problems that would interfere with the study or make it unsafe for you.  

    The study is conducted at the NIH Clinical Center in Bethesda, Maryland. The testing sessions will take up to 2.5 hours. There is no cost to participate and compensation is provided.

    First Steps to Participate in Research: Learn study details, ask about your eligibility, and consent to participate.

    To find out if you qualify, email NIMH or call 1-301-451-5087 [TTY: 1-866-411-1010].

    Study Identifiers

    • NIMH Protocol Number: 02-M-0321
    • ClinicalTrials.gov Study Number: 00047853
  • Principal Investigator: Christian Grillon, Ph.D.
  • Join a Research Study: Enrolling locally from the Washington, D.C. metro region

    Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers

    The purpose of this study is to understand brain development during childhood and brain changes with aging. We will look at brain changes and development in healthy adults and children. We will also look at brain changes and development in people with different developmental disorders, including sex chromosome variations.

    Previous studies have shown that parts of the brain develop at different times. They have also shown that brain development can be different in people with various diseases. However, we do not fully understand normal brain development and aging. We do not know how it differs in people with certain illnesses that affect thinking and behavior. We are just starting to understand how genes can affect brain development. This study examines the relationship between genes, brain development, and behavior throughout life.  Participants have a research testing visit at the start of the study, and again every 2 years. We will use tests including brain imaging with magnetic resonance imaging (MRI). We will also use physical and psychological examination and evaluation, and genetic testing. We may also ask you to have a skin biopsy, which is described in a separate consent form. We hope that a better understanding of brain development may lead to improved prevention and treatment of mental and behavioral disorders in the future.

    This study includes people in good physical health, who are over 3 years old. People in this study may be without any known psychiatric/medical conditions, or may have known conditions such as Sex Chromosome Variation, Autism Spectrum Disorder, Obsessive Compulsive Disorder, and ADHD.

    In this part of the study we are currently enrolling healthy volunteers 5-25 years old without current or past psychiatric or neurological diagnoses.

    Healthy Volunteers will have an initial visit lasting about 6 hours and will be invited to return every two years. Procedures include a physical examination, a blood draw, an MRI scan of the brain, and cognitive tests of thinking, memory, and attention.  We may also ask you to have a skin biopsy.

    The study is conducted at the NIH Clinical Center in Bethesda, Maryland (just outside Washington, D.C. There is no cost to participate in this outpatient visit and compensation is provided. Children must have parental permission to participate.

    To find out if you qualify, email NIMH or call 1-301-435-4516 [TTY: 1-866-411-1010].

    Study Identifiers

    • NIMH Protocol Number: 89-M-0006
    • ClinicalTrials.gov Study Number: 00001246
  • Principal Investigator: Armin Raznahan, M.D., Ph.D.
  • Join a Research Study: Enrolling locally from the Washington, D.C. metro region

    Healthy Research Volunteer Study

    People in good health are invited to participate as a research study volunteer. Study participants play a vital role in biomedical research by helping scientists advance knowledge and better understand, treat, and ultimately, improve health.

    The National Institute of Mental Health (NIMH) is conducting this study to create a list of healthy research volunteers who are interested in participating in additional NIMH studies. Data from healthy research volunteers compared to data from those with mental health conditions can help us understand why some people are affected while others are not.

    We invite adults in good health, over age 18, to join the online part of the study by:

    • Registering and consenting to be in the study
    • Completing questions about your medical and mental health

    Volunteers for the study will complete online questionnaires which will take about 20 minutes. They can save and come back to the questionnaires, if needed.

    After completing questionnaires, those who are eligible for an in-person appointment may be invited to the NIH Clinical Center in Bethesda, Maryland. This part of the study may include:

    • Psychological and cognitive assessments
    • Physical exam, blood and urine tests
    • Learning about additional study opportunities, as well as a brain scan (MRI) for this volunteer study

    There is no cost to participate, and compensation is provided for the in-person appointment. To join the study, sign up on this website.

    To find out if you qualify, email NIMH or call 1-240-665-0697 [TTY: 1-866-411-1010].

    Study Identifiers

    • NIMH Protocol Number: 17-M-0181
    • ClinicalTrials.gov Study Number: 03304665

    Join a Research Study: Enrolling nationally from around the country

    How Does the Covid-19 Pandemic Impact Mental Health?

    The purpose of this online study is to learn about how stressors related to the COVID-19 virus impact mental health and attention over time. We hope to better understand how people from a wide range of communities adjust their own behaviors, family lives, and daily activities to best cope with uncertainty and restrictions imposed by the pandemic.

    Participation involves completing online questionnaires and a computer task. Participation takes about two hours. Anyone at least 18 years old can participate. Participation is voluntary, and you may withdraw at any time. Compensation of up to $50. is provided.

    Please click here for more information and to begin participating.

    To find out if you qualify, email NIMH .

    Study Identifiers

    • NIMH Protocol Number: 000376
    • ClinicalTrials.gov Study Number: 04823988

    Join a Research Study: Enrolling locally from the Washington, D.C. metro region

    Memories and How the Brain Works

    Researchers are enrolling healthy volunteers for an outpatient research study to learn about the brain. A part of the study evaluates how the brain activates and represents memories. Participants will watch videos created in the “1 Second Everyday App” during a brain scan (MRI) and again during a MEG (magnetoencephalography) scan.

    The study is currently enrolling eligible participants, between the ages of 18 and 65, who are in good physical health, and have at least a high school education. The study takes 4 hours and procedures include a physical exam, brain and MEG scans, and behavioral tasks.

    The is conducted at the NIH Clinical Center in Bethesda, Maryland. There is no cost to participate and compensation is provided. 

    To find out if you qualify, email NIMH or call 1-301-827-5157 [TTY: 1-866-411-1010].

    Study Identifiers

    • NIMH Protocol Number: 93-M-0170
    • ClinicalTrials.gov Study Number: 00001360

    Join a Research Study: Enrolling locally from the Washington, D.C. metro region

    Study of the Brain, Thinking and Memory

    This part of the facial recognition study is enrolling healthy adults without psychiatric conditions, between the ages of 18 and 35, who are in good medical health, and have a bad memory for faces. The overall purpose of the study is to learn about the brain, thinking and memory in people with and without autism spectrum disorders.  

    There are 6 outpatient study visits that include interviews, thinking and memory tests, and brain scans (MRI). The study is conducted at the NIH in Bethesda, Maryland. Persons with a history of neurological or psychiatric illness, a learning disability, or those who are pregnant may not participate.

    There is no cost to participate, and compensation is provided.

    To find out if you qualify, email NIMH or call 1-301-827-5157 [TTY: 1-866-411-1010].

    Study Identifiers

    • NIMH Protocol Number: 10-M-0027
    • ClinicalTrials.gov Study Number: 01031407
  • Principal Investigator: Alex Martin, Ph.D.
  • Join a Research Study: Enrolling nationally from around the country

    The Impact of COVID-19 Pandemic on Anxiety and Motivation

    Researchers hope to better understand changes in emotional reactions and assess motivation in people during this stressful pandemic. We hope to understand the way these changes are different for people suffering from anxiety or mood disorders, and people who do not.

    Participation involves completing online questionnaires and a computer task twice (first time, and again in 8 months.) Participation each time takes about an hour. Anyone at least 18 years old can participate. Participation is voluntary, and you may withdraw at any time. Compensation is provided.

    Please click here for more information and to begin participating.

    To find out if you qualify, email NIMH .

    Study Identifiers

    • NIMH Protocol Number: 20-M-N112
    • ClinicalTrials.gov Study Number: 04377100
  • Principal Investigator: Christian Grillon, Ph.D.
  • Join a Research Study: Enrolling locally from the Washington, D.C. metro region

    TMS and Brain Function

    This research study seeks healthy adult participants to explore how transcranial magnetic stimulation (TMS) affects the brain. TMS is a non-invasive method which uses a magnet placed outside the head to stimulate precise locations inside the brain.

    This study is enrolling eligible adults ages 18-65 who are free of serious medical conditions. Participation includes three to four outpatient visits for research evaluations, brain scans, and TMS. All clinical evaluations, research tasks and visits are free of cost. Participants are compensated. The study is conducted at the NIH in Bethesda, Maryland.

    To find out if you qualify, email NIMH or call 1-301-827-0176 [TTY: 1-866-411-1010].

    Study Identifiers

    • NIMH Protocol Number: 18-M-0015
    • ClinicalTrials.gov Study Number: 03351764

    Join a Research Study: Enrolling nationally from around the country

    Understanding How Ketamine Affects Brain Chemistry

    The purpose of this study is to evaluate how a dose of ketamine affects brain chemistry, and how it alleviates depression symptoms so quickly. Ketamine is a general anesthetic medication used to put people to sleep for surgery.

    This inpatient study is enrolling eligible healthy adults, ages 18 to 65, who are free of psychiatric illness and serious medical conditions. The study lasts up to 5 days, and procedures include a ketamine infusion, psychological testing, sleep studies, an optional lumbar puncture, and optional brain scans.

    The study is conducted at the NIH Clinical Center in Bethesda, MD. There is no cost to participate and compensation is provided. This study enrolls eligible participants locally from within 50 miles of the NIH Clinical Center in Bethesda, Maryland. Travel arrangements are provided, and costs are covered by NIMH (arrangements vary by distance).

    First steps to participate include, calling NIMH, learning study details, asking about your eligibility, and consenting to participate.

    To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

    Study Identifiers

    • NIMH Protocol Number: 17-M-0060
    • ClinicalTrials.gov Study Number: 03065335
  • Principal Investigator: Carlos Zarate Jr, M.D.
  • Join a Research Study: Enrolling locally from the Washington, D.C. metro region

    Understanding the brain, mood, memory, and thinking

    This research study seeks to learn about the brain, moods, memory, thinking and concentration in healthy adults and compare them to those who have HIV infections. Researchers will evaluate the relationship among brain inflammation, protein function and MND; and how HIV infection may cause problems with blood vessel function and contribute to thinking and mood disorders, such as early dementia and depression. Researchers will compare persons with and without HIV infection.

    This study is enrolling adults ages 18 and older, fluent English speakers, who are free of certain medical conditions and HIV negative (call to find out). Participation includes 1-3 visits, cognitive evaluations, medical history, physical exam, blood work, and brain scans.

    The study is conducted at the NIH Clinical Center in Bethesda, Maryland. This study enrolls eligible participants locally from within 50 miles of NIH. There is no cost to participate. Compensation is provided. Transportation may be reimbursed. Health insurance is not required to participate.

    The first steps to consider participating in this research are to call us, learn the study details, be evaluated for eligibility and consent to participate.

    To find out if you qualify, email NIMH or call 1-800-411-1222 [TTY: 1-866-411-1010].

    Study Identifiers

    • NIMH Protocol Number: 13-N-0149
    • ClinicalTrials.gov Study Number: 01875588