Research Highlights

In the largest genome-wide association study of bipolar disorder to date, researchers found about twice as many genetic locations associated with bipolar disorder as reported in previous studies. These and other findings help improve our understanding of the biological origins of bipolar disorder.

Researchers have developed a promising new framework for suicide prevention in American Indian and Alaska Native (AI/AN) communities. The research framework expands on conventional risk reduction strategies by placing Indigenous culture, knowledge, beliefs, and community collaboration at the center of the approach.

New analysis shows suggests an association between intimate partner violence and elevated viral loads among postpartum women in South Africa.

An analysis of clinical trial data shows that improvements in emotion regulation in youth at high risk for suicide who received dialectical behavior therapy (DBT) led to a reduction in self-harm behaviors.

Researchers in the NIMH Intramural Research Program have developed a new way to measure the degree to which the proportions of an individual person’s brain differ from the proportions typically seen in the broader population. This technique yields new insights into brain development and offers tools for further study.

NIMH-supported researchers investigated suicide risk among women in the year before and year after giving birth.

In a recent study, NIMH-supported researchers found that certain types of unintentional injury have stronger associations with self-harm than others in adolescents.

NIMH is working to meet the urgent need for rapid-acting suicide prevention interventions by supporting research investigating the feasibility and safety of treatment protocols that have the potential to quickly reduce severe suicide risk in youth and adults.

The Early Psychosis Intervention Network (EPINET), an NIMH initiative aimed at determining how to best provide treatment for individuals experiencing symptoms of early psychosis, is increasing access to resources for researchers, providers, and families through a growing network of research hubs and a new website.

In a project funded by the NIMH Small Business Technology Transfer program, researchers are investigating whether mobile technology can be used to create a passive monitoring system that can predict teens’ depressive symptoms and improve the quality of their care.

NIMH, along with other NIH Institutes, is supporting the ABC-CT project, a multisite study that aims to test and refine biomarkers that can be used as objective measures of social impairment for children with autism in clinical trials, leading to more predictive and personalized treatment.

Suicide attempts by firearm are especially dangerous, with as many as 9 out of 10 attempts resulting in death. NIMH is supporting three projects focused on preventing and reducing firearm injury and mortality to help address the critical need for more research in this area.

A research project supported by NIMH analyzed multiple studies to determine the effectiveness of brief suicide prevention interventions in acute care settings.

NIMH has joined with other NIH Institutes in launching an new Accelerating Medicines Partnership focused on advancing the development of better ways to identify and treat those at clinical high risk for psychosis.

In an NIMH-supported study, researchers found that college students identifying as a sexual or gender minority had higher rates of suicidal risk factors than cisgender and heterosexual peers, and that there were significant differences in risk among sexual minority subgroups.

The need to identify effective targets for intervention in anorexia nervosa is pressing, as patient outcomes are often poor. An NIMH-funded genome-wide association study suggests that metabolic processes may play an important role in the disorder, offering a promising new avenue for investigation.

NIMH, along with other NIH Institutes, is supporting the goal of identifying autism in the first year of life by funding projects that seek to seek to translate findings related to early-emerging signs of autism into practical ASD screening tools that can be implemented in the general population and community settings.

In a study published in 2019 in the journal Nature Neuroscience, researchers funded by the National Institute of Mental Health investigated the neurobiological changes that occur in the brain circuits of mice when contextual fear memories — fear of a place where an aversive event occurred — are formed and extinguished.

Researchers were able to identify different types of rare genetic variations associated with autism spectrum disorder by analyzing data shared via the NIMH-funded Autism Sequencing Consortium.

In 2018, 11.4 million adults in the United States experienced a serious mental illness, such as schizophrenia-spectrum disorders, severe bipolar disorder, and severe depression.

The use of right unilateral ultrabrief pulse (RUL-UB) electroconvulsive therapy (ECT) in combination with the antidepressant venlafaxine to treat depression in elderly patients is well tolerated and results in minimal neurocognitive side effects, according to a new NIH-funded study published in the American Journal of Geriatric Psychiatry.

For many adults who have a mental disorder, symptoms were present—but often not recognized or addressed—in childhood and adolescence. Early treatment can help prevent more severe, lasting impairment or disability as a child grows up.

In binge-eating disorder and bulimia nervosa, people experience recurrent and frequent episodes in which they eat unusually large amounts of food and feel a sense of loss of control.

According to a 2017 report by the Bureau of Justice Statistics, approximately two-thirds of female inmates in prisons and jails and around a third of men in prisons and jails report having been diagnosed as having mental health disorder by a mental health professional.