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A study of spatial learning in mice shows that exposure to new experiences dampens established representations in the brain’s hippocampus and prefrontal cortex, allowing the mice to learn new navigation strategies.

A new study conducted by researchers at NIMH suggests that differences in the expression of gene transcripts – readouts copied from DNA that help maintain and build our cells – may hold the key to understanding how mental disorders with shared genetic risk factors result in different patterns of onset, symptoms, course of illness, and treatment responses.

A genetic study has identified neuronal abnormalities in the electrical activity of cortical cells derived from people with a rare genetic disorder called 22q11.2 deletion syndrome.

A scientific analysis of more than 2,000 brain scans found evidence for highly reproducible sex differences in the volume of certain regions in the human brain.

Researchers funded by NIMH have found that astrocytes, a type of brain cell, can harbor HIV and then spread the virus to immune cells that traffic out of the brain and into other organs.

The Strategic Plan for Research advances the Institute’s mission and helps guide future mental health research efforts.

An innovative NIMH-funded trial shows that a receptor involved in the brain’s reward system may be a viable target for treating anhedonia (or lack of pleasure), a key symptom of several mood and anxiety disorders.

NIH-supported study finds that spatial “replay” in neurons may help rats learn how to navigate toward goals.

The NIH has announced its continued support for the Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative by funding more than 180 new BRAIN Initiative awards, bringing the total 2019 budget for the program to more than $424 million.

Researchers have developed a high-tech support system that can keep a large mammalian brain from rapidly decomposing in the hours after death, enabling study of certain molecular and cellular functions.

Researchers have identified ketamine-induced brain-related changes that are responsible for maintaining the remission of behaviors related to depression in mice — findings that may help researchers develop interventions that promote lasting remission of depression in humans.

Researchers have launched an ultra-large virtual docking library expected to grow to more than 1 billion molecules by next year. It will expand by 1000-fold the number of such “make-on-demand” compounds readily available to scientists for chemical biology and drug discovery.

A lineage of young neuroscientists from diverse backgrounds trace their scientific roots to a “fear lab” in Puerto Rico that the National Institutes of Health has been supporting for two decades.

A new study in rodents has demonstrated, for the first time, that the brain’s cerebellum plays a role in controlling reward and social preference behavior—findings that shed light on the brain circuits critical to the affective and social dysfunction seen across multiple psychiatric disorders.