Science News About Schizophrenia
- Researchers Map the Genetic Landscape of Schizophrenia in the Brain
In a comprehensive postmortem genetic analysis of the caudate nucleus in the brain, NIMH-supported researchers identified many genes associated with schizophrenia risk, including a gene that regulates the flow of the chemical messenger dopamine.
- Computational Methods Identify Psychosis Symptoms in Spoken Language
Researchers used computational methods to automatically detect abnormalities in spoken language that could be used to predict symptoms of psychotic disorders including schizophrenia.
- Clinical Decision Support System Reduces Cardiovascular Risk in Patients With Serious Mental Illness
A new study shows the use of a clinical decision support system to prompt the use of shared decision-making tools, such as handouts, may result in positive impacts on long-term cardiovascular health in patients with serious mental illness.
- Gene Readouts Contribute To Distinctness of Mental Disorders
A new study conducted by researchers at NIMH suggests that differences in the expression of gene transcripts – readouts copied from DNA that help maintain and build our cells – may hold the key to understanding how mental disorders with shared genetic risk factors result in different patterns of onset, symptoms, course of illness, and treatment responses.
- NIH Initiative Expands Access to Resources for Early Psychosis Treatment and Research
The Early Psychosis Intervention Network (EPINET), an NIMH initiative aimed at determining how to best provide treatment for individuals experiencing symptoms of early psychosis, is increasing access to resources for researchers, providers, and families through a growing network of research hubs and a new website.
- NIMH Part of Collaborative Effort to Advance Early Intervention for Individuals at Risk of Developing Schizophrenia
NIMH has joined with other NIH Institutes in launching an new Accelerating Medicines Partnership focused on advancing the development of better ways to identify and treat those at clinical high risk for psychosis.
- Schizophrenia Risk Gene Linked to Cognitive Deficits in Mice
Mice with an impaired version of one the few genes definitively linked to schizophrenia showed abnormalities in working memory, mimicking those commonly seen in schizophrenia patients.
- Gene Regulators Work Together for Oversized Impact on Schizophrenia Risk
Gene expression regulators work together to raise an individual’s risk of developing schizophrenia. Schizophrenia-like gene expression changes modeled in human neurons matched changes found in patients’ brains.
- NIH Announces Funding Awards for National Early Psychosis Learning Community
NIMH awarded six research grants for studies to develop a learning health care system for the treatment of early psychosis.
- Mental Health Research Centers Forge Collaborations – with ALACRITY
Mental health research center directors emerged from a recent meeting with a renewed commitment to help each other achieve their common mission – to transform care of children, adolescents and adults with severe psychiatric disorders.
- Neuromelanin-Sensitive MRI Identified as a Potential Biomarker for Psychosis
Researchers have shown that a type of magnetic resonance imaging — called neuromelanin-sensitive MRI (NM-MRI) — is a potential biomarker for psychosis. NM-MRI signal was found to be a marker of dopamine function in people with schizophrenia and an indicator of the severity of psychotic symptoms in people with this mental illness.
- New Findings Reveal Surprising Role of the Cerebellum in Reward and Social Behaviors
A new study in rodents has demonstrated, for the first time, that the brain’s cerebellum plays a role in controlling reward and social preference behavior—findings that shed light on the brain circuits critical to the affective and social dysfunction seen across multiple psychiatric disorders.