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NIH Study Reveals Differences in Brain Activity in Children with Anhedonia

Press Release

Researchers have identified changes in brain connectivity and brain activity during rest and reward anticipation in children with anhedonia, a condition where people lose interest and pleasure in activities they used to enjoy.

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NIH Study Shows Many Preteens Screen Positive for Suicide Risk During ER Visits

Press Release

A research team found nearly one-third of youth ages 10 to 12 years screened positive for suicide risk in emergency department settings, including those seeking help for physical concerns only.

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Neuromelanin-Sensitive MRI Identified as a Potential Biomarker for Psychosis

Press Release

Researchers have shown that a type of magnetic resonance imaging — called neuromelanin-sensitive MRI (NM-MRI) — is a potential biomarker for psychosis. NM-MRI signal was found to be a marker of dopamine function in people with schizophrenia and an indicator of the severity of psychotic symptoms in people with this mental illness.

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Mega Docking Library Poised to Speed Drug Discovery

Press Release

Researchers have launched an ultra-large virtual docking library expected to grow to more than 1 billion molecules by next year. It will expand by 1000-fold the number of such “make-on-demand” compounds readily available to scientists for chemical biology and drug discovery.

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Brain Biomarkers Could Help Identify Those at Risk of Severe PTSD

Press Release

This study has shed light on the neurocomputational contributions to the development of post-traumatic stress disorder in combat veterans, finding distinct patterns for how the brain and body respond to learning danger and safety depending on the severity of PTSD symptoms.

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Puerto Rico’s “Fear Lab” Mentors Neuroscience Rigor amid Diversity

Press Release

A lineage of young neuroscientists from diverse backgrounds trace their scientific roots to a “fear lab” in Puerto Rico that the National Institutes of Health has been supporting for two decades.

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New Findings Reveal Surprising Role of the Cerebellum in Reward and Social Behaviors

Press Release

A new study in rodents has demonstrated, for the first time, that the brain’s cerebellum plays a role in controlling reward and social preference behavior—findings that shed light on the brain circuits critical to the affective and social dysfunction seen across multiple psychiatric disorders.

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Sensorimotor Domain Added to the RDoC Framework

Institute Update

The National Institute of Mental Health (NIMH) announces the addition of the new Sensorimotor domain to the Research Domain Criteria (RDoC) framework. The aim of the new domain is to help foster earlier and more precise identification of the role of motor systems disruptions in psychopathology and aid in the development of more effective treatments for people who are affected with these disruptions.

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2,000 Human Brains Yield Clues to How Genes Raise Risk for Mental Illnesses

Press Release

PsychENCODE researchers are discovering the biological mechanisms by which mental illness risk genes work in the human brain.

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New Pathways for Implementing Universal Suicide Risk Screening in Healthcare Settings

Press Release

A new report provides guidance on how to implement universal suicide risk screening of youth in medical settings. The report describes a way for hospitals to address the rising suicide rate in a way that is flexible and mindful of limited resources.

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