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Science News About Bipolar Disorder

NIMH’s Carlos Zarate Jr., M.D., Elected to National Academy of Medicine

Institute Update

Carlos Zarate Jr., M.D., chief of the Experimental Therapeutics and Pathophysiology Branch within the NIMH Intramural Research Program, has been elected to the National Academy of Medicine.

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Outdoor Light Linked with Teens’ Sleep and Mental Health

Press Release

A large-scale study of U.S. teens shows associations between outdoor, artificial light at night and health outcomes.

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2,000 Human Brains Yield Clues to How Genes Raise Risk for Mental Illnesses

Press Release

PsychENCODE researchers are discovering the biological mechanisms by which mental illness risk genes work in the human brain.

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Dynamic Associations Among Motor Activity, Sleep, Energy, and Mood Could Suggest New Focus for Depression Treatment

Science Update

A new study looking at interactions among sleep, energy, activity level, and mood suggests that instability in activity and sleep systems could lead to mood changes. The findings suggest new targets for depression treatment.

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Inflammation in Pregnant Moms Linked to Child’s Brain Development

Science Update

High levels of maternal inflammation during pregnancy have been linked to effects in children, including reduced brain circuit communications and altered long-distance brain wiring at birth, poorer cognitive function at one year – and to reduced impulse control and working memory at two years.

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Molecular Secrets Revealed: Antipsychotic Docked in its Receptor

Press Release

Scientists have deciphered the molecular structure of a widely-prescribed antipsychotic docked in its key human brain receptor. The discovery may hold clues to designing better treatments for schizophrenia, bipolar disorder and other mental illnesses.

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Brain’s Alertness Circuitry Conserved Through Evolution

Press Release

Using a molecular method likely to become widely adopted by the field, researchers have discovered brain circuitry essential for alertness – and for brain states more generally.

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Mood Stabilizing Medications an Effective Option for Older Adults with Bipolar Disorder

Science Update

Two standard medications for bipolar disorder were effective in controlling symptoms at doses tailored to older people in a clinical trial of treatment in adults over age 60.

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Coping With Familial Mental Illness in Stressful Times

Science Update

“An NIH/NIMH lifer” reveals how his Asian American family successfully coped with severe mental illness compounded by discrimination.

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Symptoms Outdo Diagnoses in Predicting Bipolar Disorder in At-Risk Youth

Science Update

Three types of symptoms emerged as powerful predictors of whether a youth with one parent with bipolar disorder will go on to develop the disorder, according to a new NIMH-funded study of 391 at-risk youth.

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Genome-Wide Study Yields Markers of Lithium Response

Science Update

Genome-Wide Study Yields Markers of Lithium Response

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Biomarkers Outperform Symptoms in Parsing Psychosis Subgroups

Press Release

Three biomarker-based categories, called “biotypes,” outperformed traditional diagnoses, such as schizophrenia and bipolar disorder with psychosis, in sorting psychosis cases into distinct subgroups on the basis of brain biology

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Disorders Share Risk Gene Pathways for Immune, Epigenetic Regulation

Science Update

Risk genes for different mental disorders work through same pathways

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