Science News About Clinical Research and Trials

An innovative NIMH-funded trial shows that a receptor involved in the brain’s reward system may be a viable target for treating anhedonia (or lack of pleasure), a key symptom of several mood and anxiety disorders.

NIH-funded research uses machine learning algorithm to predict individual response to a commonly-prescribed antidepressant.

Researchers have uncovered sex-based differences in the development of the hippocampus and amygdala—brain areas that have been implicated in the biology of several mental disorders that impact males and females differently.

NIMH awarded six research grants for studies to develop a learning health care system for the treatment of early psychosis.

Mental health research center directors emerged from a recent meeting with a renewed commitment to help each other achieve their common mission – to transform care of children, adolescents and adults with severe psychiatric disorders.

FDA approval of the postpartum depression treatment brexanolone represents the final phase of a bench-to-bedside journey for this drug — a journey that began in the NIMH Intramural Research Program. NIMH experts are available to provide information on postpartum depression and the importance of, and the science underlying, this new drug.

A research team found nearly one-third of youth ages 10 to 12 years screened positive for suicide risk in emergency department settings, including those seeking help for physical concerns only.

NIMH-funded scientists have discovered a pattern in the way a brain circuit works that may help predict the onset of psychosis. High levels of chatter, or “hyperconnectivity,” in a circuit involving the cerebellum, thalamus, and cortex emerged as a potential “neural signature” in a functional magnetic resonance imaging (fMRI) study.

Findings from a new study suggest an electronically delivered HIV prevention intervention may be effective in reducing sexually transmitted infections (STIs) and sexual risk behaviors in young men who have sex with men.

A recent clinical trial of a psychotherapy called dialectical behavior therapy (DBT)—which has been shown to be effective in reducing suicide-related behavior in adults—showed that DBT can also reduce suicide attempts and suicidal behavior in adolescents.

Researchers funded by the National Institutes of Health have shown that a therapy-based treatment for disruptive behavioral disorders can be adapted and used as an effective treatment option for early childhood depression.

The National Institutes of Health released to the scientific community an unparalleled dataset from the Adolescent Brain Cognitive Development (ABCD) study.

Two standard medications for bipolar disorder were effective in controlling symptoms at doses tailored to older people in a clinical trial of treatment in adults over age 60.

Functional connectivity magnetic resonance imaging (fcMRI) may predict which high-risk, 6-month old infants will develop autism spectrum disorder (ASD) by age 2 years.

A streamlined behavioral therapy delivered in a pediatrics practice offered much greater benefit to youth with anxiety and depression than a more standard referral to mental health care with follow-up in a clinical trial comparing the two approaches.

The study will follow the biological and behavioral development of more than 10,000 children through adolescence into early adulthood.

An individualized program of follow-up treatment with electroconvulsive therapy (ECT) combined with an antidepressant was effective in preventing relapse in patients 60 years and older who had had a successful initial course of treatment for severe depression.

Is mobile mental health research the next frontier for smartphones? Based on Dr. Patricia Areán’s pioneering BRIGHTEN study, research via smartphone app is already a reality.

Coordinated Specialty Care for First Episode Psychosis is Cost Effective

Two of the world’s largest brain tissue banks unify efforts to collect and distribute a critical number of brain donations for important autism research.

New research shows that a team-based, coordinated specialty care treatment plan produces better outcomes than typical community care for people with first episode psychosis. Investigators also found that treatment is most effective for people who receive care soon after psychotic symptoms begin.

James McPartland, Ph.D. of Yale University will lead a new four-year $28 million Biomarkers Consortium project that aims to improve clinical evaluation of treatments for social impairment in children with autism.

NIMH’s first major effort to share clinical trial research data—established before many current data registries existed—is still doing a brisk business.