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Science News About Clinical Research and Trials

Recruitment Begins for Landmark Study of Adolescent Brain Development

Press Release

The study will follow the biological and behavioral development of more than 10,000 children through adolescence into early adulthood.

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Electroconvulsive Therapy Lifts Depression, Sustains Remission in Older Adults

Science Update

An individualized program of follow-up treatment with electroconvulsive therapy (ECT) combined with an antidepressant was effective in preventing relapse in patients 60 years and older who had had a successful initial course of treatment for severe depression.

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A BRIGHT Technological Future for Mental Health Trials

Science Update

Is mobile mental health research the next frontier for smartphones? Based on Dr. Patricia Areán’s pioneering BRIGHTEN study, research via smartphone app is already a reality.

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Team-based Treatment for First Episode Psychosis Found to be High Value

Press Release

Coordinated Specialty Care for First Episode Psychosis is Cost Effective

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NIH-supported NeuroBioBank Joins Autism BrainNet in Brain Donation Initiative

Press Release

Two of the world’s largest brain tissue banks unify efforts to collect and distribute a critical number of brain donations for important autism research.

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Team-based Treatment is Better for First Episode Psychosis

Press Release

New research shows that a team-based, coordinated specialty care treatment plan produces better outcomes than typical community care for people with first episode psychosis. Investigators also found that treatment is most effective for people who receive care soon after psychotic symptoms begin.

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NIH Joins Public-Private Partnership to Fund Research on Autism Biomarkers

Press Release

James McPartland, Ph.D. of Yale University will lead a new four-year $28 million Biomarkers Consortium project that aims to improve clinical evaluation of treatments for social impairment in children with autism.

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Pioneering NIMH Data Sharing

Science Update

NIMH’s first major effort to share clinical trial research data—established before many current data registries existed—is still doing a brisk business.

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Medications for Patients with First Episode Psychosis May Not Meet Guidelines

Press Release

Many patients with first-episode psychosis receive medications that do not meet guidelines. A study finds that almost 40 % of people with first-episode psychosis in community mental health clinics across the country might benefit from medication treatment changes.

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Largest Autism Gene Dragnet Fingers 33 Prime Suspects

Science Update

Many patients with psychosis develop health risks associated with premature death early in the course of their mental illness, researchers have found.

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Groundbreaking Suicide Study

Science Update

A groundbreaking study will help researchers learn more about treating people with suicidal thoughts. Nearly 20,000 patients will be able to enroll in the trial. One of the treatments being tested was developed with the help of other patients

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Increased Health Risks Linked to First-episode Psychosis

Press Release

Many patients with psychosis develop health risks associated with premature death early in the course of their mental illness, researchers have found.

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For Schizophrenia, Newer Injectables Not Necessarily Better

Science Update

Treatment adherence is a problem among people with schizophrenia, who may not take medications because they don’t perceive its need or benefit, don’t like the side effects, or forget. To combat this issue, long-acting injectable medications are administered every 2-4 weeks. But are the new forms of these drugs better than the old ones?

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NIH Directors Discuss Sequestration and Research on C-SPAN

Science Update

Despite facing lean financial times, NIH continues to generate the most bang for the buck regarding research. Tomorrow on C-SPAN Washington Journal, NIH Directors Drs. Collins, Insel, Fauci, Varmus, and Green will field questions from the public pertaining to sequestration and research as well as other topics.

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Community-based Treatments Offset Depression Disparities

Science Update

Improving care for depression in low-income communities -- places where such help is frequently unavailable or hard to find -- provides greater benefits to those in need when community groups such as churches and even barber shops help lead the planning process, according to a new study.

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NIH Funds Industry Collaborations to Identify New Uses for Existing Compounds

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NIH Funds Industry Collaborations to Identify New Uses for Existing Compounds

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Ketamine Cousin Rapidly Lifts Depression Without Side Effects

Science Update

NMDA or glutamate receptor modulators as antidepressants have come of age. Human clinical studies demonstrated that ketamine can ward off depressive symptoms within 2 hours of administration and last for several days. Yet serious side effects are attached to this drug, including excessive sleepiness, hallucinations, and substance abuse behavior.

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NIH Study Shows People with Serious Mental Illnesses Can Lose Weight

Press Release

Losing weight is challenging for everyone. It can be particularly difficult for someone with a serious mental illness. An NIMH-funded clinical study proves that a modified diet and exercise program can work for people with serious mental illnesses. Participants lost 7 pounds more than controls—and continued to lose weight.

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NIH-funded Study Finds Community-based Efforts Increase HIV Testing, Prompt Behavior Change

Press Release

An international study supported by NIMH reported today that community efforts, in comparison to standard clinical testing and counseling, yielded greater testing and lower HIV incidence in high-risk individuals.

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Leading Neurobiologist Appointed NIMH Scientific Director

Press Release

Renowned neurobiologist Susan Amara recently joined NIMH as scientific director of its intramural research program.

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Study Documents that Some Children Lose Autism Diagnosis

Press Release

An NIH-supported study has confirmed that some children who are accurately diagnosed in early childhood with autism lose the symptoms and the diagnosis as they grow older.

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Guide Offers a Blueprint for End-of-Life Conversation With Youth

Science Update

A new guide can help young people with serious illness express how they would like to be cared for and supported.

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