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Science News About Schizophrenia

Powered-Up Probe ID’s Schizophrenia Genes That Stunt Brain Development

Science Update

Scientists have pinpointed several schizophrenia-related gene variants that alter expression of other genes in illness-implicated circuitry of the human brain.

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Schizophrenia, Autism Risk Gene Trajectories Point to Shared Causes

Science Update

Schizophrenia, autism risk gene trajectories point to shared causes

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Circuit for Experience-Informed Decision-Making ID’d in Rats

Press Release

Scientists have discovered secrets of how the brain recalls experiences of being in a particular location in making informed choices.

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Team-based Treatment for First Episode Psychosis Found to be High Value

Press Release

Coordinated Specialty Care for First Episode Psychosis is Cost Effective

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Schizophrenia’s Strongest Known Genetic Risk Deconstructed

Press Release

Versions of a gene linked to schizophrenia may trigger runaway pruning of the teenage brain’s still-maturing communications infrastructure.The gene switched on more in people with the suspect versions, who faced a higher risk of developing the disorder.

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Biomarkers Outperform Symptoms in Parsing Psychosis Subgroups

Press Release

Three biomarker-based categories, called “biotypes,” outperformed traditional diagnoses, such as schizophrenia and bipolar disorder with psychosis, in sorting psychosis cases into distinct subgroups on the basis of brain biology

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Combating Early Death in People with Serious Mental Illness

Science Update

Recent articles in JAMA Psychiatry report and comment on the premature mortality seen among adults with schizophrenia; NIMH research is underway to reduce health risk factors in people with serious mental illness.

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Team-based Treatment is Better for First Episode Psychosis

Press Release

New research shows that a team-based, coordinated specialty care treatment plan produces better outcomes than typical community care for people with first episode psychosis. Investigators also found that treatment is most effective for people who receive care soon after psychotic symptoms begin.

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Disorders Share Risk Gene Pathways for Immune, Epigenetic Regulation

Science Update

Risk genes for different mental disorders work through same pathways

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Medications for Patients with First Episode Psychosis May Not Meet Guidelines

Press Release

Many patients with first-episode psychosis receive medications that do not meet guidelines. A study finds that almost 40 % of people with first-episode psychosis in community mental health clinics across the country might benefit from medication treatment changes.

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Increased Health Risks Linked to First-episode Psychosis

Press Release

Many patients with psychosis develop health risks associated with premature death early in the course of their mental illness, researchers have found.

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Suspect Gene Corrupts Neural Connections

Press Release

Researchers have shown in patients’ cells how a rare mutation in a suspect gene disrupts the expression of dozens of other genes underlying neural connections.

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Schizophrenia’s Genetic “Skyline” Rising

Press Release

The largest genomic dragnet of any psychiatric disorder to date has unmasked 108 chromosomal sites harboring inherited variations in the genetic code linked to schizophrenia, 83 of which had not been previously reported.

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For Schizophrenia, Newer Injectables Not Necessarily Better

Science Update

Treatment adherence is a problem among people with schizophrenia, who may not take medications because they don’t perceive its need or benefit, don’t like the side effects, or forget. To combat this issue, long-acting injectable medications are administered every 2-4 weeks. But are the new forms of these drugs better than the old ones?

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NIMH’s Dr. Robert Heinssen Receives Special Presidential Commendation from APA

Science Update

NIMH’s Dr. Robert Heinssen Receives Special Presidential Commendation from APA

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Brain Region Singled Out for Social Memory, Possible Therapeutic Target for Select Brain Disorders

Science Update

The hippocampus houses learning and memory—specifically the storage of knowledge of who, what, where, and when. Using a special transgenic mouse, researchers have now pinpointed a hippocampal region called CA2 that is important for social memory, the ability of animal to recognize another of the same species. Understanding this region could be useful in understanding and treating disorders characterized by altered social behaviors such as schizophrenia, bipolar disorder, and autism.

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NeuroBioBank Gives Researchers One-stop Access to Post-mortem Brains

Press Release

The NIH NeuroBioBank provides researchers with one-stop access to post-mortem brains.

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Webinar on Childhood-Onset Schizophrenia with NIMH’s Judith L. Rapoport, M.D.

Science Update

Register for a webinar on September 9 featuring NIMH scientist Dr. Judith Rapoport, who will discuss brain development in childhood and adolescence and childhood-onset schizophrenia.

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New Data Reveal Extent of Genetic Overlap Between Major Mental Disorders

Press Release

The largest genome-wide study of its kind has determined how much five major mental illnesses are traceable to the same common inherited genetic variations.

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Stray Prenatal Gene Network Suspected in Schizophrenia

Press Release

Researchers have reverse-engineered the outlines of a disrupted prenatal gene network in schizophrenia, by tracing spontaneous mutations to where and when they likely cause damage in the brain.

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NIH Funds Industry Collaborations to Identify New Uses for Existing Compounds

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NIH Funds Industry Collaborations to Identify New Uses for Existing Compounds

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Taming Suspect Gene Reverses Schizophrenia-like Abnormalities in Mice

Press Release

Scientists have reversed behavioral and brain abnormalities in adult mice that resemble some features of schizophrenia, by restoring normal expression to the gene Neuregulin1, which makes a protein important for brain development.

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Flu in Pregnancy May Quadruple Child’s Risk for Bipolar Disorder

Press Release

Pregnant mothers’ exposure to the flu has been linked to a nearly 4-fold increased risk for bipolar disorder in their adult child.

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NIH Study Shows People with Serious Mental Illnesses Can Lose Weight

Press Release

Losing weight is challenging for everyone. It can be particularly difficult for someone with a serious mental illness. An NIMH-funded clinical study proves that a modified diet and exercise program can work for people with serious mental illnesses. Participants lost 7 pounds more than controls—and continued to lose weight.

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Developing Male Brain Exposed to Less Stress-Protective Protein

Science Update

Why are rates of schizophrenia and autism higher in males? New evidence implicates an enzyme expressed in the placenta that helps protect the developing fetal brain from adverse effects of maternal stress early in pregnancy.

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Five Major Mental Disorders Share Genetic Roots

Science Update

Five major mental disorders share some of the same genetic risk factors, the largest genome-wide study of its kind has found.

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Mapping Brain Circuits Provides Clues to Schizophrenia, Earlier Detection of Psychosis

Science Update

A newly identified brain circuit could lead to earlier detection of psychosis in patients with schizophrenia.

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