Skip to content

Science News About Schizophrenia

Inflammation in Pregnant Moms Linked to Child’s Brain Development

Science Update

High levels of maternal inflammation during pregnancy have been linked to effects in children, including reduced brain circuit communications and altered long-distance brain wiring at birth, poorer cognitive function at one year – and to reduced impulse control and working memory at two years.

Continue Reading

Suspect Molecules Overlap in Autism, Schizophrenia, Bipolar Disorder

Science Update

Depression, schizophrenia and autism spectrum disorder share some of the same patterns of suspect gene expression – molecular signatures.

Continue Reading

Molecular Secrets Revealed: Antipsychotic Docked in its Receptor

Press Release

Scientists have deciphered the molecular structure of a widely-prescribed antipsychotic docked in its key human brain receptor. The discovery may hold clues to designing better treatments for schizophrenia, bipolar disorder and other mental illnesses.

Continue Reading

Scientists Give Star Treatment to Lesser-Known Cells Crucial for Brain Development

Press Release

Star-shaped support brain cells, astrocytes, growing in 3-D “organoids” in a dish develop similarly as those in human brain tissue.

Continue Reading

Patient-Derived Support Cells Stunt Mouse Brain Development

Science Update

Support cells generated from patients with childhood onset schizophrenia stunted neural circuit development when grafted into developing mouse brains.

Continue Reading

Our Brains Harbor “Residual Echo” of Neanderthal Genes

Science Update

Researchers have produced the first direct evidence that parts of our brains implicated in mental disorders may be shaped by a “residual echo” from our ancient past. The more a person’s genome carries genetic vestiges of Neanderthals, the more certain parts of his or her brain and skull resemble those of humans’ evolutionary cousins that went extinct 40,000 years ago.

Continue Reading

Brain “Relay” Also Key to Holding Thoughts in Mind

Press Release

Long overlooked as a mere “relay,” an egg-like structure in the middle of the brain also turns out to play a pivotal role in tuning-up thinking circuity. A trio of studies in mice are revealing that the thalamus sustains the ability to distinguish categories and hold thoughts in mind. It might even become a target for interventions for psychiatric disorders marked by working memory problems, such as schizophrenia.

Continue Reading

Estrogen Alters Memory Circuit Function in Women with Gene Variant

Science Update

Brain scans reveal that fluctuations in estrogen can trigger atypical functioning in a key brain memory circuit in women with a common version of a gene. Since working memory function is often disturbed in mental disorders, such gene-hormone interactions are suspect mechanisms that may confer risk.

Continue Reading

Higher Death Rate Among Youth with First Episode Psychosis

Press Release

A new study shows that young people with first episode psychosis have a much higher death rate than previously thought. Researchers looked at people aged 16-30 and found that the group died at a rate at least 24 times greater than the same age group in the general population.

Continue Reading

Powered-Up Probe ID’s Schizophrenia Genes That Stunt Brain Development

Science Update

Scientists have pinpointed several schizophrenia-related gene variants that alter expression of other genes in illness-implicated circuitry of the human brain.

Continue Reading

Schizophrenia, Autism Risk Gene Trajectories Point to Shared Causes

Science Update

Schizophrenia, autism risk gene trajectories point to shared causes

Continue Reading

Circuit for Experience-Informed Decision-Making ID’d in Rats

Press Release

Scientists have discovered secrets of how the brain recalls experiences of being in a particular location in making informed choices.

Continue Reading

Team-based Treatment for First Episode Psychosis Found to be High Value

Press Release

Coordinated Specialty Care for First Episode Psychosis is Cost Effective

Continue Reading

Schizophrenia’s Strongest Known Genetic Risk Deconstructed

Press Release

Versions of a gene linked to schizophrenia may trigger runaway pruning of the teenage brain’s still-maturing communications infrastructure.The gene switched on more in people with the suspect versions, who faced a higher risk of developing the disorder.

Continue Reading

Biomarkers Outperform Symptoms in Parsing Psychosis Subgroups

Press Release

Three biomarker-based categories, called “biotypes,” outperformed traditional diagnoses, such as schizophrenia and bipolar disorder with psychosis, in sorting psychosis cases into distinct subgroups on the basis of brain biology

Continue Reading

Combating Early Death in People with Serious Mental Illness

Science Update

Recent articles in JAMA Psychiatry report and comment on the premature mortality seen among adults with schizophrenia; NIMH research is underway to reduce health risk factors in people with serious mental illness.

Continue Reading

Team-based Treatment is Better for First Episode Psychosis

Press Release

New research shows that a team-based, coordinated specialty care treatment plan produces better outcomes than typical community care for people with first episode psychosis. Investigators also found that treatment is most effective for people who receive care soon after psychotic symptoms begin.

Continue Reading

Disorders Share Risk Gene Pathways for Immune, Epigenetic Regulation

Science Update

Risk genes for different mental disorders work through same pathways

Continue Reading

Medications for Patients with First Episode Psychosis May Not Meet Guidelines

Press Release

Many patients with first-episode psychosis receive medications that do not meet guidelines. A study finds that almost 40 % of people with first-episode psychosis in community mental health clinics across the country might benefit from medication treatment changes.

Continue Reading

Increased Health Risks Linked to First-episode Psychosis

Press Release

Many patients with psychosis develop health risks associated with premature death early in the course of their mental illness, researchers have found.

Continue Reading

Suspect Gene Corrupts Neural Connections

Press Release

Researchers have shown in patients’ cells how a rare mutation in a suspect gene disrupts the expression of dozens of other genes underlying neural connections.

Continue Reading

Schizophrenia’s Genetic “Skyline” Rising

Press Release

The largest genomic dragnet of any psychiatric disorder to date has unmasked 108 chromosomal sites harboring inherited variations in the genetic code linked to schizophrenia, 83 of which had not been previously reported.

Continue Reading

For Schizophrenia, Newer Injectables Not Necessarily Better

Science Update

Treatment adherence is a problem among people with schizophrenia, who may not take medications because they don’t perceive its need or benefit, don’t like the side effects, or forget. To combat this issue, long-acting injectable medications are administered every 2-4 weeks. But are the new forms of these drugs better than the old ones?

Continue Reading

NIMH’s Dr. Robert Heinssen Receives Special Presidential Commendation from APA

Science Update

NIMH’s Dr. Robert Heinssen Receives Special Presidential Commendation from APA

Continue Reading

Brain Region Singled Out for Social Memory, Possible Therapeutic Target for Select Brain Disorders

Science Update

The hippocampus houses learning and memory—specifically the storage of knowledge of who, what, where, and when. Using a special transgenic mouse, researchers have now pinpointed a hippocampal region called CA2 that is important for social memory, the ability of animal to recognize another of the same species. Understanding this region could be useful in understanding and treating disorders characterized by altered social behaviors such as schizophrenia, bipolar disorder, and autism.

Continue Reading