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Molecular Tool Parses Social Fear Circuit Intertwined with Aggression Hub

Science Update

A genetic engineering tool has disentangled seemingly hopelessly intertwined brain circuits for social fear and aggression in mice.

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Worldwide Study Seeks to Unlock the Brain’s Genetic Code

Science Update

Big data pinpoints genetic variation linked to brain volume and risk for disorders.

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NIMH’s Karen F. Berman, M.D. elected to National Academy of Medicine

Press Release

At its annual meeting for 2016, the National Academy of Medicine (NAM) announced the election of 79 regular members, including the National Institute of Mental Health’s (NIMH Karen F. Berman, M.D. One of the highest honors in the fields of health and medicine, election to the Academy recognizes outstanding professional achievement and commitment to service.

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NIH Nearly Doubles Investment in BRAIN Initiative Research

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NIH’s third round of grants to support the goals of the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative total just over $150 million.

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NIMH Releases Strategic Research Priorities Update

Science Update

National Institute of Mental Health (NIMH) recently released updates to its Strategic Research Priorities.

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How “Quickly Forgotten” Early Life Experiences Mature the Brain

Science Update

Brain memory circuitry’s keen sensitivity to experience during an early critical period enables long-term memory ability to develop through practice.

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NIMH Grantees Named Recipients of Prestigious Kavli Prize

Science Update

Three NIMH grantees have been named recipients of the 2016 Kavli Prize in Neuroscience.

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Connectome Map More Than Doubles Human Cortex’s Known Regions

Press Release

Researchers have mapped 180 distinct areas on our brain’s cortex — more than twice the number previously known.

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Human Connectome Project Marks its First Phase

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Studies based on a database made available by the Human Connectome Project’s first phase reveal that an individual’s brain connectivity can predict his or her behavior.

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Secrets to Our Smarts Hidden in the Folds of Our Cortex

Science Update

The more folding in the thinking parts of our brain, the smarter we are – to a degree.

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Distractible Mice Offer Clues to Attention Deficit

Science Update

A recent NIMH-funded study sheds new light on how the brain’s processing of sensory information, a key impairment in autism and ADHD, can affect higher level cognitive functions, such as attention and decision making.

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Circuit for Experience-Informed Decision-Making ID’d in Rats

Press Release

Scientists have discovered secrets of how the brain recalls experiences of being in a particular location in making informed choices.

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A BRIGHT Technological Future for Mental Health Trials

Science Update

Is mobile mental health research the next frontier for smartphones? Based on Dr. Patricia Areán’s pioneering BRIGHTEN study, research via smartphone app is already a reality.

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Experimental Combination Surprises with Anti-HIV Effectiveness

Science Update

A compound developed by NIH-supported scientists to protect the nervous system from HIV surprised researchers by augmenting the effectiveness of an investigational antiretroviral drug beyond anything expected.

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Circuit Tweak Boosts Social Memory in Mice

Science Update

Researchers have boosted the staying power of a social memory at least 80-fold by stimulating a circuit they discovered in mouse brain.

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Biomarker for Brain Excitability May Help Track Medication Effect

Science Update

NIMH scientists have recently discovered a link between order in the activity of neurons in the brain and excitability—how likely it is that individual neurons will “fire”— which may provide a means for monitoring treatment of conditions like epilepsy that would be less invasive and thus more versatile than current methods

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NIH-supported NeuroBioBank Joins Autism BrainNet in Brain Donation Initiative

Press Release

Two of the world’s largest brain tissue banks unify efforts to collect and distribute a critical number of brain donations for important autism research.

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Blog, Video Spotlight NIMH Neuroscience Trainee

Science Update

A recent NIH Director’s Blog and Lab TV video feature a young neuroscientist whose discoveries as a graduate student – about a key maternal behavior – were supported, in part, by a NIMH training grant.

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Embracing the SPIRIT of reducing suicide

Science Update

NIMH, NIH, and the National Institute of Justice are collaborating on a 4-year, $6.8 million study called Suicide Prevention for at-Risk Individuals in Transition or “SPIRIT.” The study focuses on the high-risk individuals who are transitioning from jail to community. SPIRIT is NIMH’s first major investment in suicide prevention in the justice system.

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Psychosis Treatment Program Expands in New York

Science Update

New York expanded OnTrackNY, a treatment program for youth with psychosis which is an offshoot of one of the two NIMH-funded Recovery After an Initial Schizophrenia Episode (RAISE) studies.

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Webinar Series – Office for Research on Disparities and Global Mental Health

Science Update

View the archived webinars with NIMH experts and grantees, which focus on training, research, and methodology

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Boys More Likely to Have Antipsychotics Prescribed, Regardless of Age

Press Release

Boys are more likely than girls to receive an antipsychotic prescription regardless of age, according to a new study published in JAMA Psychiatry.

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Study May Help Department of Veterans Affairs Find Patients with High Risk of Suicide

Press Release

Scientists used health data to identify very small groups of VHA patients with very high, predicted suicide risk. Such methods can help the VHA to target suicide prevention efforts for patients at high risk, and may have more wide-ranging benefits.

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A Patient’s Budding Cortex -- in a Dish?

Press Release

Scientists have perfected mini cultured 3-D structures that grow and function much like the outer mantle – the key working tissue, or cortex – of the brain of the person from whom they were derived.

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Souped-up Remote Control Switches Behaviors On-and-off in Mice

Press Release

Neuroscientists have perfected a chemical-genetic remote control for brain circuitry and behavior.

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Brain Circuitry for Positive vs Negative Memories Discovered in Mice

Press Release

Neuroscientists have discovered brain circuitry for encoding positive and negative learned associations in mice.

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A New Look at Racial/Ethnic Differences in Mental Health Service Use Among Adults

Science Update

New report on mental health service use among racial/ethnic groups

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New NIMH Strategic Plan Aims to Focus, Accelerate Mental Health Research

Press Release

New NIMH Strategic Plan balances the need for long-term investments in basic research with urgent mental health needs.

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NIH Announces Follow that Cell Challenge Finalists

Press Release

NIH has selected 5 prize winners and 11 finalists in Phase 1 of its Follow that Cell Challenge, which aims to develop new ways to predict the behavior and function of a single cell in complex tissue over time.

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Brain Recalls Old Memories via New Pathways

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Brain retrieval circuitry shifts as fear memory ages

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Seeking Single Cells’ Secrets

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NIH has awarded grants totaling $7.9 million in 2014 to 25 research teams who are unraveling the workings of single cells.

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Soldiers at Increased Suicide Risk after Leaving Hospital

Press Release

Soldiers hospitalized with a psychiatric disorder have a higher suicide risk in the year following discharge from the hospital.

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NIMH Twitter Chat on Depression and the Development of Novel Medications

Science Update

NIMH Twitter Chat on Depression and the Development of Novel Medications

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NIH Announces First Wave of Funding for BRAIN Initiative Research

Science Update

Calling it “the beginning of an ambitious journey”, the National Institutes of Health announced its first wave of grants in support of the BRAIN Initiative.

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Magnetic Stimulation Boosts Human Memory, Network Connectivity

Science Update

Scientists have improved memory for associations between faces and words by electromagnetically stimulating neural connections in a brain network.

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Suspect Gene Corrupts Neural Connections

Press Release

Researchers have shown in patients’ cells how a rare mutation in a suspect gene disrupts the expression of dozens of other genes underlying neural connections.

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Follow that Cell

Press Release

The National Institutes of Health is challenging science innovators to compete for prizes totaling up to $500,000, by developing new ways to track the health status of a single cell in complex tissue over time.

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NIMH Twitter Chat on Premenstrual Dysphoric Disorder

Science Update

NIMH Twitter Chat on Premenstrual Dysphoric Disorder

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How Might New Neurons Buffer Against Stress?

Science Update

Over the past decade or so, evidence has emerged suggesting that the birth of new neurons in the adult brain’s memory hub, or hippocampus, may play a key role the action of antidepressants, resilience to stress, the benefits of exercise and enriched environments, and preventing memory loss. But understanding how it might work has remained elusive. NIMH researchers in NIH’s new Porter Neuroscience Research Center are following up leads.

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NIMH Twitter Chat on Men and Depression

Science Update

NIMH Twitter Chat on Men and Depression

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NIMH Twitter Chat on Postpartum Depression

Science Update

NIMH Twitter Chat on Postpartum Depression

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Channel Makeover Bioengineered to Switch Off Neurons

Press Release

Scientists have bioengineered an enhancement to a cutting edge technology that provides instant control over brain circuit activity with a flash of light. The research adds the same level of control over switching neurons off that, until now, had been limited to switching them on. What had been working through a weak pump now works through a highly responsive channel -- like going from a squirt to a gushing hose.

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NIMH Twitter Chat on Autism Spectrum Disorder Diagnosis

Science Update

NIMH Twitter Chat on Autism Spectrum Disorder Diagnosis

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Learn About the Adolescent Brain with Expert Dr. Jay Giedd on May 8!

Science Update

NIMH expert Dr. Jay Giedd will discuss the developing adolescent brain at a community event on May 8. The event will be video archived.

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The 22nd NIMH Conference on Mental Health Services Research

Science Update

The 22nd National Institute of Mental Health (NIMH) Conference on Mental Health Services Research (MHSR): Research in Pursuit of a Learning Mental Health Care System, will be convened on April 23–25, 2014, at the Natcher Conference Center on the National Institutes of Health (NIH) Campus, Bethesda, MD.

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NIH-funded Brain Atlas Offers Clues to Psychiatric Disorders

Press Release

A brain blueprint maps where genes are tuned on and off during mid-pregnancy—when most brain disorders such as autism and schizophrenia occur.

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Most Individuals Receive Health Services a Year Before Suicide Death

Science Update

Undetected suicide risk is a critical issue in primary care. According to a NIMH-funded study published in the February 2014 issue of the Journal of General Internal Medicine, 83 percent of individuals received health care services in the year prior to suicide death and half did not have a mental health diagnosis.

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Disorganized Cortical Patches Suggest Prenatal Origin of Autism

Press Release

The architecture of the autistic brain is speckled with patches of abnormal neurons, according to research partially funded by the National Institute of Mental Health, published in the New England Journal of Medicine on March 27, 2014.

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Brain Region Singled Out for Social Memory, Possible Therapeutic Target for Select Brain Disorders

Science Update

The hippocampus houses learning and memory—specifically the storage of knowledge of who, what, where, and when. Using a special transgenic mouse, researchers have now pinpointed a hippocampal region called CA2 that is important for social memory, the ability of animal to recognize another of the same species. Understanding this region could be useful in understanding and treating disorders characterized by altered social behaviors such as schizophrenia, bipolar disorder, and autism.

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Suicide in the Military: Army-NIH Funded Study Points to Risk and Protective Factors

Press Release

Although the suicide attempt and death rates in the U.S. Army have been historically below the civilian rate, these rates began climbing in the early 2000s, and by 2008, exceeded those of civilians. A joint study between the Army and NIMH, called Army STARRS, recently released findings that shed light on the problem.

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NIMH Twitter Chat on Eating Disorders

Science Update

NIMH Twitter Chat on Eating Disorders

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NICHD/NIMH Podcast on Youth Violence

Science Update

NIMH/NICHD experts explain what sparks and halts youth violence.

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Transgenic Mice Lines Aid in Brain Circuit Imaging

Science Update

Neuroscientists have generated over 250 genetically engineered mice lines that will help further our understanding of the human brain.

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NIMH Twitter Chat on Depression and Older Adults

Science Update

Join NIMH’s Jovier Evans, Ph.D., Chief of the Geriatric Translational Neuroscience Program, for a Twitter Chat on depression and older adults.

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NIH Directors Discuss Sequestration and Research on C-SPAN

Science Update

Despite facing lean financial times, NIH continues to generate the most bang for the buck regarding research. Tomorrow on C-SPAN Washington Journal, NIH Directors Drs. Collins, Insel, Fauci, Varmus, and Green will field questions from the public pertaining to sequestration and research as well as other topics.

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NeuroBioBank Gives Researchers One-stop Access to Post-mortem Brains

Press Release

The NIH NeuroBioBank provides researchers with one-stop access to post-mortem brains.

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NIMH Twitter Chat on Bullying Prevention

Science Update

NIH experts Drs. Chris Sarampote and Valerie Maholmes discuss bullying prevention.

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NIMH Scientists Honored with 2013 Brain & Behavior Research Foundation Awards

Science Update

Miss the Twitter chat on the teen brain and Brain Awareness Week? Read the transcript.

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Streamlined Method Offers Shortcut to Generating Neurons for Discovery

Science Update

Researchers have found a shortcut to rapidly convert induced human stem cells into healthy neurons for “disease-in-a-dish” discovery – and, ultimately, personalized medicine.

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Three NIH Scientists Elected into IOM

Science Update

NIMH’s Daniel S. Pine, M.D., is one of three NIH scientists elected as members of the prestigious Institute of Medicine.

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NIMH Grantee Receives 2013 Nobel Prize

Science Update

Thomas C. Südhof, M.D., along with James E. Rothman, Ph.D., and Randy W. Schekman, Ph.D., received the 2013 Nobel Prize in Physiology or Medicine for their discoveries delineating how a cell organizes its transport system.

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Science/AAAS Google+ Hangout on the Adolescent Brain Featuring NIMH’s Jay Giedd, M.D.

Science Update

NIMH scientist Jay Giedd, M.D. discusses the teen brain with Science/AAAS in a Google+ Hangout.

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Former NIMH Grantee Receives 2013 MacArthur Fellow Award

Science Update

Susan Murphy, Ph.D., a statistician from the University of Michigan and former NIMH grantee, is one of 24 recipients of the MacArthur “Genius” Award.

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Jay Giedd on PBS Documentary “Brains on Trial”

Science Update

NIMH’s Jay Giedd discusses brain scan research with Alan Alda in the two-episode PBS documentary “Brains on Trial.”

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NIMH Grantees Receive 2013 Lasker Award

Science Update

Two National Institute of Mental Health (NIMH) grantees recently collected the prestigious 2013 Albert Lasker Basic Medical Research Award for their meticulous mapping of the molecular mechanisms involved in neurotransmitter release, the process by which the brain send and receives chemical messengers.

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NIMH Twitter Chat on Suicide Prevention

Science Update

To commemorate World Suicide Prevention Day on September 10, 2013, NIMH will host a twitter chat on the topic.

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Introduction to RDoC

Science Update

Bruce Cuthbert, Ph.D., director, NIMH Division of Translational Research and Treatment Development, discusses the Research Domain Criteria (RDoC) initiative, which he coordinates.

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Tom Insel Discusses The BRAIN Initiative on The Charlie Rose Brain Series

Science Update

With nearly 100 billion neurons and 100 trillion connections, the human brain remains one of the greatest mysteries in science and one of the greatest challenges in medicine. NIMH Director Thomas Insel recently went on The Charlie Rose Brain Series to discuss The BRAIN Initiative, which aims to create better tools to solve this mystery.

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NIMH Twitter Chat on Post-traumatic Stress Disorder

Science Update

Learn about post-traumatic stress disorder by joining NIMH’s Farris Tuma for a Twitter chat.

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Twitter Chat on The Teen Brain—NIMH Experts Discuss Brain Awareness Week

Science Update

Miss the Twitter chat on the teen brain and Brain Awareness Week? Read the transcript.

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Differences in On/Off Switches Help Explain How the Human Brain Evolved

Science Update

A recent NIMH-funded study identified small regions of the genome that are uniquely regulated in human neurons, but not in primate neurons. The findings provide insight into human intellectual function and risk for human diseases, including autism and Alzheimer’s disease.

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Leading Neurobiologist Appointed NIMH Scientific Director

Press Release

Renowned neurobiologist Susan Amara recently joined NIMH as scientific director of its intramural research program.

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